Methoxetamine
Encyclopedia
Methoxetamine or 3-MeO-2-Oxo-PCE is a chemical of the arylcyclohexylamine
class which has been sold as a designer drug
. It is a derivative of ketamine
that also contains structural features of eticyclidine
and 3-MeO-PCP
. Methoxetamine is thought to behave as a NMDA receptor antagonist
and dopamine reuptake inhibitor
, though it has not been formally profiled pharmacologically. Methoxetamine differs from many other dissociative anesthetics of the arylcyclohexylamine class in that it was designed for grey-market distribution. Methoxetamine is a product of rational drug design
: its N-ethyl group was chosen to increase potency, lessening the risk of interstitial cystitis
that can result from the accumulation of ketamine-like metabolites in the urinary bladder.
Arylcyclohexylamine
Arylcyclohexylamines, also known as arylcyclohexamines or arylcyclohexanamines, are a chemical class of pharmaceutical, designer, and experimental drugs.- History :...
class which has been sold as a designer drug
Designer drug
Designer drug is a term used to describe drugs that are created to get around existing drug laws, usually by preparing analogs or derivatives of existing drugs by modifying their chemical structure to varying degrees, or less commonly by finding drugs with entirely different chemical structures...
. It is a derivative of ketamine
Ketamine
Ketamine is a drug used in human and veterinary medicine. Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar. Pharmacologically, ketamine is classified as an NMDA receptor antagonist...
that also contains structural features of eticyclidine
Eticyclidine
Eticyclidine is a dissociative anesthetic drug with hallucinogenic effects. It is similar in effects to phencyclidine but is slightly more potent...
and 3-MeO-PCP
3-MeO-PCP
3-Methoxyphencyclidine is a dissociative anesthetic drug with hallucinogenic and sedative effects. It is around the same potency as phencyclidine, but has slightly different effects due to its altered binding profile at various targets, particularly being somewhat more potent as an NMDA antagonist...
. Methoxetamine is thought to behave as a NMDA receptor antagonist
NMDA receptor antagonist
NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the N-methyl d-aspartate receptor . They are used as anesthesia for animals and, less commonly, for humans; the state of anesthesia they induce is referred to as dissociative anesthesia...
and dopamine reuptake inhibitor
Dopamine reuptake inhibitor
A dopamine reuptake inhibitor is a type of drug that acts as a reuptake inhibitor for the neurotransmitter dopamine by blocking the action of the dopamine transporter...
, though it has not been formally profiled pharmacologically. Methoxetamine differs from many other dissociative anesthetics of the arylcyclohexylamine class in that it was designed for grey-market distribution. Methoxetamine is a product of rational drug design
Drug design
Drug design, also sometimes referred to as rational drug design or structure-based drug design, is the inventive process of finding new medications based on the knowledge of the biological target...
: its N-ethyl group was chosen to increase potency, lessening the risk of interstitial cystitis
Interstitial cystitis
Interstitial cystitis or bladder pain syndrome is a chronic, oftentimes severely debilitating disease of the urinary bladder...
that can result from the accumulation of ketamine-like metabolites in the urinary bladder.