Merrifield resin
Encyclopedia
Merrifield Resin is a polystyrene
resin based on a copolymer of styrene and chloromethylstyrene. In addition this polymer is also cross-link
ed with divinylbenzene
present in the monomer composition up to 5%. Merrifield resin is named after its inventor, Robert Bruce Merrifield
(1984 winner of the Nobel Prize in Chemistry), and used in Solid-phase synthesis
.
Polystyrene
Polystyrene ) also known as Thermocole, abbreviated following ISO Standard PS, is an aromatic polymer made from the monomer styrene, a liquid hydrocarbon that is manufactured from petroleum by the chemical industry...
resin based on a copolymer of styrene and chloromethylstyrene. In addition this polymer is also cross-link
Cross-link
Cross-links are bonds that link one polymer chain to another. They can be covalent bonds or ionic bonds. "Polymer chains" can refer to synthetic polymers or natural polymers . When the term "cross-linking" is used in the synthetic polymer science field, it usually refers to the use of...
ed with divinylbenzene
Divinylbenzene
Divinylbenzene consists of a benzene ring bonded to two vinyl groups. It is related to styrene by the addition of a second vinyl group. Divinylbenzene, as it is usually encountered, is a 2:1 mixture of m- and p-divinylbenzene, containing also the corresponding ethylvinylbenzene isomers. It is...
present in the monomer composition up to 5%. Merrifield resin is named after its inventor, Robert Bruce Merrifield
Robert Bruce Merrifield
Robert Bruce Merrifield was an American biochemist who won the Nobel Prize in Chemistry in 1984 for the invention of solid phase peptide synthesis.-Early life:...
(1984 winner of the Nobel Prize in Chemistry), and used in Solid-phase synthesis
Solid-phase synthesis
In chemistry, solid-phase synthesis is a method in which molecules are bound on a bead and synthesized step-by-step in a reactant solution; compared with normal synthesis in a liquid state, it is easier to remove excess reactant or byproduct from the product. In this method, building blocks are...
.