Matrix metalloproteinase inhibitor
Encyclopedia
A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinase
s. As they inhibit cell migration
they have antiangiogenic effects. They may be both endogenous and exogenous.
The most notorious endogenous metalloproteinases are tissue inhibitor of metalloproteinases
(TIMP). There are also cartilage-derived angiogenesis inhibitors.
Exogenous matrix metalloproteinase inhibitors include batimastat and marimastat
.
Matrix metalloproteinase
Matrix metalloproteinases are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily....
s. As they inhibit cell migration
Cell migration
Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, wound healing and immune responses all require the orchestrated movement of cells in particular directions to specific locations...
they have antiangiogenic effects. They may be both endogenous and exogenous.
The most notorious endogenous metalloproteinases are tissue inhibitor of metalloproteinases
Tissue inhibitor of metalloproteinases
The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases , which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4....
(TIMP). There are also cartilage-derived angiogenesis inhibitors.
Exogenous matrix metalloproteinase inhibitors include batimastat and marimastat
Marimastat
Marimastat was a proposed antineoplastic drug developed by British Biotech. It acted as a broad-spectrum matrix metalloproteinase inhibitor.Marimastat performed poorly in clinical trials, and development was terminated....
.