Mafenide
Encyclopedia
Mafenide is a sulfonamide
.
.
Mafenide (Sulfamylon) can interfere with the kidney's role in hydrogen ion excretion, resulting in metabolic acidosis.
Mafenide is a topical sulfonamide used as adjunctive therapy of second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms including Pseudomonas aeruginosa. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could result in metabolic acidosis. This drug was approved by the FDA in 1948.
Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol
/prednisolone
or bacitracin
are more appropriate for facial burns.
Contraindications/Precautions:Sulfonamide hypersensitivity; renal impairment.
Topical dosage:
Adults and children: Apply topically to a thickness of approximately 1.6 mm, to cleaned and debrided wound once or twice per day with a sterile gloved hand. Burned area should be covered with cream at all times.
Sulfonamide (medicine)
Sulfonamide or sulphonamide is the basis of several groups of drugs. The original antibacterial sulfonamides are synthetic antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame...
.
Uses
It is used to treat severe burnsBurn (injury)
A burn is a type of injury to flesh caused by heat, electricity, chemicals, light, radiation or friction. Most burns affect only the skin . Rarely, deeper tissues, such as muscle, bone, and blood vessels can also be injured...
.
Mafenide (Sulfamylon) can interfere with the kidney's role in hydrogen ion excretion, resulting in metabolic acidosis.
Mafenide is a topical sulfonamide used as adjunctive therapy of second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms including Pseudomonas aeruginosa. Mafenide is metabolized to a carbonic anhydrase inhibitor, which could result in metabolic acidosis. This drug was approved by the FDA in 1948.
Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol
Chloramphenicol
Chloramphenicol is a bacteriostatic antimicrobial that became available in 1949. It is considered a prototypical broad-spectrum antibiotic, alongside the tetracyclines, and as it is both cheap and easy to manufacture it is frequently found as a drug of choice in the third world.Chloramphenicol is...
/prednisolone
Prednisolone
Prednisolone is the active metabolite of prednisone, which is also used as a drug.-Uses:Prednisolone is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and auto-immune conditions such as...
or bacitracin
Bacitracin
Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, isolation of which was first reported in 1945....
are more appropriate for facial burns.
Mechanism of Action
Mechanism of Action: Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns.Contraindications/Precautions:Sulfonamide hypersensitivity; renal impairment.
Adverse Reactions
Superinfection, pain or burning upon application, rash, pruritus, tachypnea, hyperventilation, metabolic acidosis.Dosage:
For use adjunctive therapy of second- and third-degree burns to prevent infection:Topical dosage:
Adults and children: Apply topically to a thickness of approximately 1.6 mm, to cleaned and debrided wound once or twice per day with a sterile gloved hand. Burned area should be covered with cream at all times.