MSH2
Encyclopedia
MSH2 is a gene
commonly associated with Hereditary nonpolyposis colorectal cancer
.
with Exonuclease 1
, MSH3
, MSH6
, CHEK2
, MAX
, Ataxia telangiectasia and Rad3 related
and BRCA1
.
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
commonly associated with Hereditary nonpolyposis colorectal cancer
Hereditary nonpolyposis colorectal cancer
Lynch syndrome is an autosomal dominant genetic condition which has a high risk of colon cancer as well as other cancers including endometrium, ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin...
.
Interactions
MSH2 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Exonuclease 1
Exonuclease 1
Exonuclease 1 is an enzyme that in humans is encoded by the EXO1 gene.This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity . It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in DNA mismatch repair and...
, MSH3
MSH3
DNA mismatch repair protein Msh3 is a protein that in humans is encoded by the MSH3 gene.-Interactions:MSH3 has been shown to interact with MSH2, PCNA and BRCA1.-Further reading:...
, MSH6
MSH6
MSH6 is a gene commonly associated with hereditary nonpolyposis colorectal cancer.-Function:MSH6 contributes to ADP and ATP binding. It also contributes to ATPase activity...
, CHEK2
CHEK2
CHEK2 is the official symbol for the human gene CHK2 checkpoint homolog. It is located on the long arm of chromosome 22.-Function:The protein encoded by this gene, CHK2 a protein kinase that is activated in response to DNA damage and is involved in cell cycle arrest.In response to DNA damage and...
, MAX
MAX (gene)
Protein max also known as myc-associated factor X is a protein that in humans is encoded by the MAX gene.- Function :Protein max is a member of the basic helix-loop-helix leucine zipper family of transcription factors. It is able to form homodimers and heterodimers with other family members, which...
, Ataxia telangiectasia and Rad3 related
Ataxia telangiectasia and Rad3 related
Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein or FRAP-related protein 1 is an enzyme that in humans is encoded by the ATR gene...
and BRCA1
BRCA1
BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...
.