This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology

International Union of Biochemistry and Molecular Biology

The International Union of Biochemistry and Molecular Biology is an international non-governmental organisation concerned with biochemistry and molecular biology...

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EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds (Aminoacyl tRNA synthetase

Aminoacyl tRNA synthetase

An aminoacyl tRNA synthetase is an enzyme that catalyzes the esterification of a specific amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA. This is sometimes called "charging" the tRNA with the amino acid...

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: tyrosine-tRNA ligase

Tyrosine-tRNA ligase

In enzymology, a tyrosine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-tyrosine, and RNA, whereas its 3 products are AMP, triphosphate, and L-tyrosyl-tRNA....

: tryptophan-tRNA ligase

Tryptophan-tRNA ligase

In enzymology, a tryptophan-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-tryptophan, and tRNA, whereas its 3 products are AMP, diphosphate, and L-tryptophyl-tRNATrp....

: threonine-tRNA ligase

Threonine-tRNA ligase

In enzymology, a threonine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-threonine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-threonyl-tRNA....

: leucine-tRNA ligase

Leucine-tRNA ligase

In enzymology, a leucine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-leucine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-leucyl-tRNA....

: isoleucine-tRNA ligase

Isoleucine-tRNA ligase

In enzymology, an isoleucine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-isoleucine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-isoleucyl-tRNA....

: lysine-tRNA ligase

Lysine-tRNA ligase

In enzymology, a lysine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-lysine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-lysyl-tRNA....

: alanine-tRNA ligase

Alanine-tRNA ligase

In enzymology, an alanine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-alanine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-alanyl-tRNA....

: Deleted: valine-tRNA ligase

Valine-tRNA ligase

In enzymology, a valine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-valine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-valyl-tRNA....

: methionine-tRNA ligase

Methionine-tRNA ligase

In enzymology, a methionine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-methionine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-methionyl-tRNA....

: serine-tRNA ligase

Serine-tRNA ligase

In enzymology, a serine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-serine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-seryl-tRNA....

: aspartate-tRNA ligase

Aspartate-tRNA ligase

In enzymology, an aspartate-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-aspartate, and tRNA, whereas its 3 products are AMP, diphosphate, and L-aspartyl-tRNA....

: D-alanine-poly(phosphoribitol) ligase

D-alanine-poly(phosphoribitol) ligase

In enzymology, a D-alanine—poly ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, D-alanine, and poly, whereas its 3 products are AMP, diphosphate, and O-D-alanyl-poly.This enzyme belongs to the family of ligases, to be specific those forming...

: glycine-tRNA ligase

Glycine-tRNA ligase

In enzymology, a glycine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, glycine, and tRNA, whereas its 3 products are AMP, diphosphate, and glycyl-tRNA....

: proline-tRNA ligase

Proline-tRNA ligase

In enzymology, a proline—tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-proline, and tRNA, whereas its 3 products are AMP, diphosphate, and L-prolyl-tRNA....

: cysteine-tRNA ligase

Cysteine-tRNA ligase

In enzymology, a cysteine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-cysteine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-cysteinyl-tRNA....

: glutamate-tRNA ligase

Glutamate-tRNA ligase

In enzymology, a glutamate-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and tRNA, whereas its 3 products are AMP, diphosphate, and L-glutamyl-tRNA....

: glutamine-tRNA ligase

Glutamine-tRNA ligase

In enzymology, a glutamine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-glutaminyl-tRNA....

: arginine-tRNA ligase

Arginine-tRNA ligase

In enzymology, an arginine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-arginine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-arginyl-tRNA....

: phenylalanine-tRNA ligase

Phenylalanine-tRNA ligase

In enzymology, a phenylalanine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-phenylalanine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-phenylalanyl-tRNA....

: histidine-tRNA ligase

Histidine-tRNA ligase

In enzymology, a histidine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-histidine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA....

: asparagine-tRNA ligase

Asparagine-tRNA ligase

In enzymology, an asparagine-tRNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-asparagine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-asparaginyl-tRNA....

: aspartate-tRNAAsn ligase

Aspartate-tRNAAsn ligase

In enzymology, an aspartate-tRNAAsn ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-aspartate, and tRNAAsx, whereas its 3 products are AMP, diphosphate, and aspartyl-tRNAAsx....

: glutamate-tRNAGln ligase

Glutamate-tRNAGln ligase

In enzymology, a glutamate-tRNAGln ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and tRNAGlx, whereas its 3 products are AMP, diphosphate, and glutamyl-tRNAGlx....

: lysine-tRNAPyl ligase

Lysine-tRNAPyl ligase

In enzymology, a lysine-tRNAPyl ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-lysine, and tRNA, whereas its 3 products are AMP, diphosphate, and L-lysyl-tRNA....

EC 6.2.1: Acid-Thiol Ligases

: acetate-CoA ligase: butyrate-CoA ligase

Butyrate-CoA ligase

In enzymology, a butyrate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA....

: long-chain-fatty-acid-CoA ligase: succinate-CoA ligase (GDP-forming)

Succinate-CoA ligase (GDP-forming)

In enzymology, a succinate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are GTP, succinate, and CoA, whereas its 3 products are GDP, phosphate, and succinyl-CoA....

: succinate-CoA ligase (ADP-forming)

Succinate-CoA ligase (ADP-forming)

In enzymology, a succinate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, succinate, and CoA, whereas its 3 products are ADP, phosphate, and succinyl-CoA....

: glutarate-CoA ligase

Glutarate-CoA ligase

In enzymology, a glutarate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, glutarate, and CoA, whereas its 3 products are ADP, phosphate, and glutaryl-CoA....

: cholate-CoA ligase: oxalate-CoA ligase

Oxalate-CoA ligase

In enzymology, an oxalate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, oxalate, and CoA, whereas its 3 products are AMP, diphosphate, and oxalyl-CoA....

: malate-CoA ligase

Malate-CoA ligase

In enzymology, a malate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, malate, and CoA, whereas its 3 products are ADP, phosphate, and malyl-CoA....

: acid-CoA ligase (GDP-forming)

Acid-CoA ligase (GDP-forming)

In enzymology, an acid-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are GTP, acid, and CoA, whereas its 3 products are GDP, phosphate, and acyl-CoA....

: biotin-CoA ligase

Biotin-CoA ligase

In enzymology, a biotin-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin, and CoA, whereas its 3 products are AMP, diphosphate, and biotinyl-CoA....

: 4-coumarate-CoA ligase

4-coumarate-CoA ligase

In enzymology, a 4-coumarate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 4-coumarate, and CoA, whereas its 3 products are AMP, diphosphate, and 4-coumaroyl-CoA....

: acetate-CoA ligase (ADP-forming)

Acetate-CoA ligase (ADP-forming)

In enzymology, an acetate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acetate, and CoA, whereas its 3 products are ADP, phosphate, and acetyl-CoA....

: 6-carboxyhexanoate-CoA ligase

6-carboxyhexanoate-CoA ligase

In enzymology, a 6-carboxyhexanoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 6-carboxyhexanoate, and CoA, whereas its 3 products are AMP, diphosphate, and 6-carboxyhexanoyl-CoA....

: arachidonate-CoA ligase

Arachidonate-CoA ligase

In enzymology, an arachidonate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, arachidonate, and CoA, whereas its 3 products are AMP, diphosphate, and arachidonoyl-CoA....

: acetoacetate-CoA ligase

Acetoacetate-CoA ligase

In enzymology, an acetoacetate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acetoacetate, and CoA, whereas its 3 products are AMP, diphosphate, and acetoacetyl-CoA....

: propionate-CoA ligase

Propionate-CoA ligase

In enzymology, a propionate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, propanoate, and CoA, whereas its 3 products are AMP, diphosphate, and propanoyl-CoA....

: citrate-CoA ligase

Citrate-CoA ligase

In enzymology, a citrate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, citrate, and CoA, whereas its 3 products are ADP, phosphate, and -citryl-CoA....

: long-chain-fatty-acid-luciferin-component ligase

Long-chain-fatty-acid-luciferin-component ligase

In enzymology, a long-chain-fatty-acid-luciferin-component ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acid, and protein, whereas its 3 products are AMP, diphosphate, and acyl-protein thioester....

: long-chain-fatty-acid-(acyl-carrier-protein) ligase

Long-chain-fatty-acid-(acyl-carrier-protein) ligase

In enzymology, a long-chain-fatty-acid-[acyl-carrier-protein] ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acid, and acyl-carrier-protein, whereas its 3 products are AMP, diphosphate, and acyl-[acyl-carrier-protein].This enzyme belongs to the...

: Covered by EC 6.2.1.30: (citrate (pro-3S)-lyase) ligase

(citrate (pro-3S)-lyase) ligase

In enzymology, a citrate -lyase ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acetate, and citrate -lyase, whereas its 3 products are AMP, diphosphate, and citrate -lyase.This enzyme belongs to the family of ligases, specifically those forming...

: dicarboxylate-CoA ligase

Dicarboxylate-CoA ligase

In enzymology, a dicarboxylate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, alphaomega-dicarboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and omega-carboxyacyl-CoA....

: phytanate-CoA ligase

Phytanate-CoA ligase

In enzymology, a phytanate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, phytanate, and CoA, whereas its 3 products are AMP, diphosphate, and phytanoyl-CoA....

: benzoate-CoA ligase

Benzoate-CoA ligase

In enzymology, a benzoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, benzoate, and CoA, whereas its 3 products are AMP, diphosphate, and benzoyl-CoA....

: o-succinylbenzoate-CoA ligase

O-succinylbenzoate-CoA ligase

In enzymology, an o-succinylbenzoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, o-succinylbenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and o-succinylbenzoyl-CoA....

: 4-hydroxybenzoate-CoA ligase

4-hydroxybenzoate-CoA ligase

In enzymology, a 4-hydroxybenzoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 4-hydroxybenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and 4-hydroxybenzoyl-CoA....

: 3a,7a-dihydroxy-5b-cholestanate-CoA ligase: Deleted, now EC 6.2.1.7: phenylacetate-CoA ligase

Phenylacetate-CoA ligase

In enzymology, a phenylacetate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, phenylacetate, and CoA, whereas its 3 products are AMP, diphosphate, and phenylacetyl-CoA....

: 2-furoate-CoA ligase

2-furoate-CoA ligase

In enzymology, a 2-furoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 2-furoate, and CoA, whereas its 3 products are AMP, diphosphate, and 2-furoyl-CoA....

: anthranilate-CoA ligase

Anthranilate-CoA ligase

In enzymology, an anthranilate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, anthranilate, and CoA, whereas its 3 products are AMP, diphosphate, and anthranilyl-CoA....

: 4-chlorobenzoate-CoA ligase

4-chlorobenzoate-CoA ligase

In enzymology, a 4-chlorobenzoate-CoA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are 4-chlorobenzoate, CoA, and ATP, whereas its 3 products are 4-chlorobenzoyl-CoA, AMP, and diphosphate....

: trans-feruloyl-CoA synthase

Trans-feruloyl-CoA synthase

In enzymology, a trans-feruloyl-CoA synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ferulic acid, CoASH, and ATP, whereas its two products are trans-feruloyl-CoA and products of ATP breakdown....

EC 6.3.1: Acid-Ammonia (or Amine) Ligases (Amide Synthases)

: aspartate-ammonia ligase

Aspartate-ammonia ligase

In enzymology, an aspartate-ammonia ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-aspartate, and NH3, whereas its 3 products are AMP, diphosphate, and L-asparagine....

: glutamate-ammonia ligase: Now EC 6.3.4.13: aspartate-ammonia ligase (ADP-forming)

Aspartate-ammonia ligase (ADP-forming)

In enzymology, an aspartate-ammonia ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-aspartate, and NH3, whereas its 3 products are ADP, phosphate, and L-asparagine....

: NAD+ synthase

NAD+ synthase

In enzymology, a NAD+ synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, deamido-NAD+, and NH3, whereas its 3 products are AMP, diphosphate, and NAD+....

: glutamate-ethylamine ligase

Glutamate-ethylamine ligase

In enzymology, a glutamate-ethylamine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and ethylamine, whereas its 3 products are ADP, phosphate, and N5-ethyl-L-glutamine....

: 4-methyleneglutamate-ammonia ligase

4-methyleneglutamate-ammonia ligase

In enzymology, a 4-methyleneglutamate-ammonia ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 4-methylene-L-glutamate, and NH3, whereas its 3 products are AMP, diphosphate, and 4-methylene-L-glutamine....

: glutathionylspermidine synthase

Glutathionylspermidine synthase

In enzymology, a glutathionylspermidine synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are glutathione, spermidine, and ATP, whereas its 3 products are glutathionylspermidine, ADP, and phosphate....

: trypanothione synthase

Trypanothione synthase

In enzymology, a trypanothione synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are glutathione, glutathionylspermidine, and ATP, whereas its 3 products are N1,N8-bisspermidine, ADP, and phosphate....

: adenosylcobinamide-phosphate synthase: glutamate-putrescine ligase

Glutamate-putrescine ligase

In enzymology, a glutamate-putrescine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and putrescine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamylputrescine....

EC 6.3.2: Acid-Amino-Acid Ligases (Peptide Synthases)

: pantoate-b-alanine ligase: glutamate-cysteine ligase

Glutamate-cysteine ligase

In enzymology, a glutamate-cysteine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and L-cysteine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamyl-L-cysteine....

: glutathione synthase

Glutathione synthase

In enzymology, a glutathione synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, gamma-L-glutamyl-L-cysteine, and glycine, whereas its 3 products are ADP, phosphate, and glutathione....

: D-alanine-D-alanine ligase

D-alanine-D-alanine ligase

In enzymology, a D-alanine—D-alanine ligase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are ATP and D-alanine, whereas its 3 products are ADP, phosphate, and D-alanyl-D-alanine....

: phosphopantothenate-cysteine ligase

Phosphopantothenate-cysteine ligase

In enzymology, a phosphopantothenate-cysteine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are CTP, -4'-phosphopantothenate, and L-cysteine, whereas its 3 products are CMP, diphosphate, and N-[-4'-phosphopantothenoyl]-L-cysteine.This enzyme belongs to the...

: phosphoribosylaminoimidazolesuccinocarboxamide synthase

Phosphoribosylaminoimidazolesuccinocarboxamide synthase

In enzymology, a phosphoribosylaminoimidazolesuccinocarboxamide synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 5-amino-1-imidazole-4-carboxylate, and L-aspartate, whereas its 4 products are ADP, phosphate, -2-[5-amino-1-imidazole-4-, and...

: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase

In enzymology, an UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate, and L-lysine, whereas its 3 products are ADP, phosphate, and...

: UDP-N-acetylmuramate-L-alanine ligase

UDP-N-acetylmuramate-L-alanine ligase

In enzymology, an UDP-N-acetylmuramate-L-alanine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, UDP-N-acetylmuramate, and L-alanine, whereas its 3 products are ADP, phosphate, and UDP-N-acetylmuramoyl-L-alanine.This enzyme belongs to the family of...

: UDP-N-acetylmuramoylalanine-D-glutamate ligase: UDP-N-acetylmuramoylalanyl-tripeptide-D-alanyl-D-alanine ligase: carnosine synthase

Carnosine synthase

In enzymology, a carnosine synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-histidine, and beta-alanine, whereas its 3 products are AMP, diphosphate, and carnosine....

: dihydrofolate synthase

Dihydrofolate synthase

In enzymology, a dihydrofolate synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 7,8-dihydropteroate, and L-glutamate, whereas its 3 products are ADP, phosphate, and 7,8-dihydropteroylglutamate....

: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diamino-pimelate ligase: 2,3-dihydroxybenzoate-serine ligase

2,3-dihydroxybenzoate-serine ligase

In enzymology, a 2,3-dihydroxybenzoate-serine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 2,3-dihydroxybenzoate, and L-serine, whereas its two products are products of ATP breakdown and N--L-serine.This enzyme belongs to the family of ligases,...

: Deleted, due to EC 6.3.2.10: D-alanine-alanyl-poly(glycerolphosphate) ligase

D-alanine-alanyl-poly(glycerolphosphate) ligase

In enzymology, a D-alanine-alanyl-poly ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, D-alanine, and alanyl-poly, whereas its 3 products are ADP, phosphate, and D-alanyl-alanyl-poly.This enzyme belongs to the family of ligases, specifically those...

: tetrahydrofolate synthase

Tetrahydrofolate synthase

In enzymology, a tetrahydrofolate synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, tetrahydropteroyl-[gamma-Glu]n, and L-glutamate, whereas its 3 products are ADP, phosphate, and tetrahydropteroyl-[gamma-Glu]n+1.This enzyme belongs to the family of...

: g-glutamylhistamine synthase: ubiquitin-protein ligase: indoleacetate-lysine synthetase

Indoleacetate-lysine synthetase

In enzymology, an indoleacetate-lysine synthetase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, acetate, and L-lysine, whereas its 3 products are ADP, phosphate, and N6-[acetyl]-L-lysine....

: ubiquitin-calmodulin ligase

Ubiquitin-calmodulin ligase

In enzymology, an ubiquitin-calmodulin ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, calmodulin, and ubiquitin, whereas its 3 products are AMP, diphosphate, and n-calmodulin....

: diphthine-ammonia ligase

Diphthine-ammonia ligase

In enzymology, a diphthine-ammonia ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, diphthine, and NH3, whereas its 3 products are ADP, phosphate, and diphthamide....

: homoglutathione synthase

Homoglutathione synthase

In enzymology, a homoglutathione synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, gamma-L-glutamyl-L-cysteine, and beta-alanine, whereas its 3 products are ADP, phosphate, and gamma-L-glutamyl-L-cysteinyl-beta-alanine.This enzyme belongs to the...

: tyrosine-arginine ligase

Tyrosine-arginine ligase

In enzymology, a tyrosine-arginine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-tyrosine, and L-arginine, whereas its 3 products are AMP, diphosphate, and L-tyrosyl-L-arginine....

: tubulin-tyrosine ligase

Tubulin-tyrosine ligase

In enzymology, a tubulin-tyrosine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, detyrosinated alpha-tubulin, and L-tyrosine, whereas its 3 products are alpha-tubulin, ADP, and phosphate....

: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

In enzymology, a N--L-cysteinyl-D-valine synthase is an enzyme that catalyzes the chemical reactionThe 5 substrates of this enzyme are ATP, L-2-aminohexanedioate, L-cysteine, L-valine, and H2O, whereas its 3 products are AMP, diphosphate, and...

: aerobactin synthase

Aerobactin synthase

In enzymology, an aerobactin synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, citrate, N6-acetyl-N6-hydroxy-L-lysine, and H2O, whereas its 3 products are ADP, phosphate, and aerobactin....

EC 6.3.3: Cyclo-Ligases

: phosphoribosylformylglycinamidine cyclo-ligase: 5-formyltetrahydrofolate cyclo-ligase

5-formyltetrahydrofolate cyclo-ligase

In enzymology, a 5-formyltetrahydrofolate cyclo-ligase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are ATP and 5-formyltetrahydrofolate, whereas its 3 products are ADP, phosphate, and 5,10-methenyltetrahydrofolate.This enzyme belongs to the family of...

: dethiobiotin synthase

Dethiobiotin synthase

In enzymology, a dethiobiotin synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 7,8-diaminononanoate, and CO2, whereas its 3 products are ADP, phosphate, and dethiobiotin....

: (carboxyethyl)arginine b-lactam-synthase

EC 6.3.4: Other Carbon-Nitrogen Ligases

: GMP synthase

GMP synthase

-Enzymology:In enzymology, a GMP synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, xanthosine 5'-phosphate, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, GMP, and L-glutamate.This enzyme belongs to the family of ligases,...

: CTP synthase

CTP synthase

CTP synthase is an enzyme involved in pyrimidine biosynthesis that interconverts UTP and CTP.- Enzyme Structure :...

: formate-tetrahydrofolate ligase

Formate-tetrahydrofolate ligase

In enzymology, a formate-tetrahydrofolate ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, formate, and tetrahydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyltetrahydrofolate....

: adenylosuccinate synthase

Adenylosuccinate synthase

In molecular biology, Adenylosuccinate synthase is an enzyme that plays an important role in purine biosynthesis, by catalysing the guanosine triphosphate -dependent conversion of inosine monophosphate and aspartic acid to guanosine diphosphate , phosphate and N--AMP...

: argininosuccinate synthase: urea carboxylase

Urea carboxylase

In enzymology, an urea carboxylase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, urea, and HCO3-, whereas its 3 products are ADP, phosphate, and urea-1-carboxylate ....

: ribose-5-phosphate-ammonia ligase

Ribose-5-phosphate-ammonia ligase

In enzymology, a ribose-5-phosphate-ammonia ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, ribose 5-phosphate, and NH3, whereas its 3 products are ADP, phosphate, and 5-phosphoribosylamine....

: imidazoleacetate-phosphoribosyldiphosphate ligase

Imidazoleacetate-phosphoribosyldiphosphate ligase

In enzymology, an imidazoleacetate-phosphoribosyldiphosphate ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, imidazole-4-acetate, and 5-phosphoribosyl diphosphate, whereas its 4 products are ADP, phosphate, 1-imidazole-4-acetate, and...

: biotin-(methylmalonyl-CoA-carboxytransferase) ligase

Biotin-(methylmalonyl-CoA-carboxytransferase) ligase

In enzymology, a biotin-[methylmalonyl-CoA-carboxytransferase] ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin, and apo-[methylmalonyl-CoA:pyruvate carboxytransferase], whereas its 3 products are AMP, diphosphate, and...

: biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase

Biotin-(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase

In enzymology, a biotin-[propionyl-CoA-carboxylase ] ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin, and apo-[propionyl-CoA:carbon-dioxide ligase , whereas its 3 products are AMP, diphosphate, and propionyl-CoA:carbon-dioxide ligase .This...

: biotin-(methylcrotonoyl-CoA-carboxylase) ligase

Biotin-(methylcrotonoyl-CoA-carboxylase) ligase

In enzymology, a biotin-[methylcrotonoyl-CoA-carboxylase] ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin, and apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase ], whereas its 3 products are AMP, diphosphate, and...

: glutamate-methylamine ligase

Glutamate-methylamine ligase

In enzymology, a glutamate-methylamine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, L-glutamate, and methylamine, whereas its 3 products are ADP, phosphate, and N5-methyl-L-glutamine....

: phosphoribosylamine-glycine ligase

Phosphoribosylamine-glycine ligase

In enzymology, a phosphoribosylamine-glycine ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, 5-phospho-D-ribosylamine, and glycine, whereas its 3 products are ADP, phosphate, and N1-glycinamide.This enzyme belongs to the family of ligases,...

: biotin carboxylase

Biotin carboxylase

In enzymology, a biotin carboxylase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin-carboxyl-carrier protein, and CO2, whereas its 3 products are ADP, phosphate, and carboxybiotin-carboxyl-carrier protein....

: biotin-(acetyl-CoA-carboxylase) ligase

Biotin-(acetyl-CoA-carboxylase) ligase

In enzymology, a biotin-[acetyl-CoA-carboxylase] ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon-dioxide ligase ], whereas its 3 products are AMP, diphosphate, and acetyl-CoA:carbon-dioxide ligase .This enzyme...

: carbamoyl-phosphate synthase (ammonia): formate-dihydrofolate ligase

Formate-dihydrofolate ligase

In enzymology, a formate—dihydrofolate ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, formate, and dihydrofolate, whereas its 3 products are ADP, phosphate, and 10-formyldihydrofolate....

EC 6.3.5: Carbon-Nitrogen Ligases with Glutamine as Amido-N-Donor

: NAD+ synthase (glutamine-hydrolysing)

NAD+ synthase (glutamine-hydrolysing)

In enzymology, a NAD+ synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, deamido-NAD+, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, NAD+, and L-glutamate....

: GMP synthase (glutamine-hydrolysing): phosphoribosylformylglycinamidine synthase

Phosphoribosylformylglycinamidine synthase

In enzymology, a phosphoribosylformylglycinamidine synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, N2-formyl-N1-glycinamide, L-glutamine, and H2O, whereas its 4 products are ADP, phosphate, 2--N1-acetamidine, and L-glutamate.This enzyme belongs to...

: asparagine synthase (glutamine-hydrolysing): carbamoyl-phosphate synthase (glutamine-hydrolysing): asparaginyl-tRNA synthase (glutamine-hydrolysing)

Asparaginyl-tRNA synthase (glutamine-hydrolysing)

In enzymology, an asparaginyl-tRNA synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, aspartyl-tRNA, and L-glutamine, whereas its 4 products are ADP, phosphate, asparaginyl-tRNA, and L-glutamate.This enzyme belongs to the family of ligases,...

: glutaminyl-tRNA synthase (glutamine-hydrolysing)

Glutaminyl-tRNA synthase (glutamine-hydrolysing)

In enzymology, a glutaminyl-tRNA synthase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, glutamyl-tRNA, and L-glutamine, whereas its 4 products are ADP, phosphate, glutaminyl-tRNA, and L-glutamate.This enzyme belongs to the family of ligases,...

: aminodeoxychorismate synthase

Aminodeoxychorismate synthase

In enzymology, an aminodeoxychorismate synthase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are chorismate and L-glutamine, whereas its two products are 4-amino-4-deoxychorismate and L-glutamate....

: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)

Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)

In enzymology, a hydrogenobyrinic acid a,c-diamide synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, hydrogenobyrinic acid, L-glutamine, and H2O, whereas its 4 products are ADP, phosphate, hydrogenobyrinic acid a,c-diamide, and L-glutamate.This...

: adenosylcobyric acid synthase (glutamine-hydrolysing)

Adenosylcobyric acid synthase (glutamine-hydrolysing)

In enzymology, an adenosylcobyric acid synthase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, adenosylcobyrinic acid a,c-diamide, L-glutamine, and H2O, whereas its 4 products are ADP, phosphate, adenosylcobyric acid, and L-glutamate.This enzyme belongs...

EC 6.4: Forming Carbon-Carbon Bonds

: pyruvate carboxylase

Pyruvate carboxylase

Pyruvate carboxylase is an enzyme of the ligase class that catalyzes the irreversible carboxylation of pyruvate to form oxaloacetate .It is an important anaplerotic reaction that creates oxaloacetate from pyruvate...

: acetyl-CoA carboxylase

Acetyl-CoA carboxylase

Acetyl-CoA carboxylase is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase and carboxyltransferase...

: propionyl-CoA carboxylase

Propionyl-CoA carboxylase

Propionyl-CoA carboxylase catalyses the carboxylation reaction of propionyl CoA in the mitochondrial matrix. The enzyme is biotin dependent. The product of the reaction is -methylmalonyl CoA. Propionyl CoA is the end product of metabolism of odd-chain fatty acids, and is also a metabolite of most...

: methylcrotonoyl-CoA carboxylase: geranoyl-CoA carboxylase

Geranoyl-CoA carboxylase

In enzymology, a geranoyl-CoA carboxylase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, geranoyl-CoA, and HCO3-, whereas its 3 products are ADP, phosphate, and 3-pent-2-enedioyl-CoA....

: acetone carboxylase

Acetone carboxylase

In enzymology, an acetone carboxylase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are acetone, CO2, ATP, and H2O, whereas its 3 products are acetoacetate, AMP, and phosphate....

EC 6.5: Forming Phosphoric Ester Bonds

: DNA ligase (ATP): DNA ligase (NAD+): RNA ligase (ATP)

RNA ligase (ATP)

In enzymology, an RNA ligase is an enzyme that catalyzes the chemical reactionThe 3 substrates of this enzyme are ATP, n, and m, whereas its 3 products are AMP, diphosphate, and n+m....

: RNA-3'-phosphate cyclase

RNA-3'-phosphate cyclase

In enzymology, a RNA-3'-phosphate cyclase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are ATP and RNA 3'-terminal-phosphate, whereas its 3 products are AMP, diphosphate, and RNA terminal-2',3'-cyclic-phosphate....

EC 6.6.1: Forming Coordination Complexes

: magnesium chelatase

Magnesium chelatase

Magnesium-chelatase is a three-component enzyme that catalyses the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of bacteriochlorophyll...

: cobaltochelatase

Cobaltochelatase

Cobalt chelatase is an enzyme that catalyzes the chemical reactionThe 4 substrates of this enzyme are ATP, hydrogenobyrinic acid a,c-diamide, Co2+, and H2O, whereas its 4 products are ADP, phosphate, cobyrinic acid a,c-diamide, and H+....