Joffroy's sign
Encyclopedia
Joffroy's sign is a clinical sign
Medical sign
A medical sign is an objective indication of some medical fact or characteristic that may be detected by a physician during a physical examination of a patient....

 in which there is a lack of wrinkling of the forehead when a patient looks up with the head bent forwards. It occurs in patients with exophthalmos
Exophthalmos
Exophthalmos is a bulging of the eye anteriorly out of the orbit. Exophthalmos can be either bilateral or unilateral . Measurement of the degree of exophthalmos is performed using an exophthalmometer...

 in Graves disease.

The sign is named after Alexis Joffroy
Alexis Joffroy
Alix Joffroy was a French neurologist and psychiatrist remembered for describing Joffroy's sign. He studied in Paris, earning his doctorate in 1873, becoming médecin des hôpitaux in 1879 and agrégé in 1880...

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