Jeryl Lynn
Encyclopedia
Jeryl Lynn are strains of mumps virus used in the Mumpsvax
mumps
vaccine
made by Merck
. The strains are named after Jeryl Lynn Hilleman. In 1963 Ms. Hilleman's father Dr. Maurice Hilleman
, was leading efforts to produce a mumps vaccine
for Merck. He cultured the mumps virus from her throat, and in 1967 a vaccine was produced from this which is now widely used.
The Jeryl Lynn strains used in the manufacture of Mumpsvax later turned out to contain two distinguishable viral substrains, JL1 and JL2.
Further research showed that the JL1 strain was preferentially selected by propagation in Vero and CEF
cell cultures. The JL2 strain was preferentially selected by passage in embryonated chicken eggs.
In the U.S.A. the Jeryl Lynn strain-based vaccines supplanted the previous, killed virus, vaccine in 1978.
Mumpsvax
Mumpsvax is a mumps vaccine made of mumps virus. Mumpsvax is a product of Merck & Co.,Inc. The vaccine is a component of Merck's three-virus MMR vaccine....
mumps
Mumps
Mumps is a viral disease of the human species, caused by the mumps virus. Before the development of vaccination and the introduction of a vaccine, it was a common childhood disease worldwide...
vaccine
Mumps vaccine
Several varieties of mumps vaccine have been used since 1949, and at least 10 strains were in use in 2006:The first vaccine was a killed mumps virus vaccine developed in 1948 and used in the United States from 1950-1978. This vaccine produced little immune memory, thus had a short duration of...
made by Merck
Merck & Co.
Merck & Co., Inc. , also known as Merck Sharp & Dohme or MSD outside the United States and Canada, is one of the largest pharmaceutical companies in the world. The Merck headquarters is located in Whitehouse Station, New Jersey, an unincorporated area in Readington Township...
. The strains are named after Jeryl Lynn Hilleman. In 1963 Ms. Hilleman's father Dr. Maurice Hilleman
Maurice Hilleman
Maurice Ralph Hilleman was an American microbiologist who specialized in vaccinology and developed over three dozen vaccines, more than any other scientist...
, was leading efforts to produce a mumps vaccine
Mumps vaccine
Several varieties of mumps vaccine have been used since 1949, and at least 10 strains were in use in 2006:The first vaccine was a killed mumps virus vaccine developed in 1948 and used in the United States from 1950-1978. This vaccine produced little immune memory, thus had a short duration of...
for Merck. He cultured the mumps virus from her throat, and in 1967 a vaccine was produced from this which is now widely used.
The Jeryl Lynn strains used in the manufacture of Mumpsvax later turned out to contain two distinguishable viral substrains, JL1 and JL2.
Further research showed that the JL1 strain was preferentially selected by propagation in Vero and CEF
CEF
CEF may stand for:* Caixa Econômica Federal* Canadian Equestrian Federation, now known as Equine Canada* Canadian Expeditionary Force* Central Experimental Farm, Ottawa, Canada* Centre d'Étude de la Forêt...
cell cultures. The JL2 strain was preferentially selected by passage in embryonated chicken eggs.
In the U.S.A. the Jeryl Lynn strain-based vaccines supplanted the previous, killed virus, vaccine in 1978.