IRF4
Encyclopedia
Interferon regulatory factor 4 is a protein
that in humans is encoded by the IRF4 gene
, also known as MUM1. In melanocytic cells the IRF4 gene may be regulated by MITF
.
with STAT6
, NFATC2
, BCL6
and SPI1
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the IRF4 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
, also known as MUM1. In melanocytic cells the IRF4 gene may be regulated by MITF
Microphthalmia-associated transcription factor
Microphthalmia-associated transcription factor is a basic helix-loop-helix leucine zipper transcription factor involved in melanocyte and osteoclast development.-Clinical significance:...
.
Interactions
IRF4 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with STAT6
STAT6
STAT6 is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell...
, NFATC2
NFATC2
Nuclear factor of activated T-cells, cytoplasmic 2 is a protein that in humans is encoded by the NFATC2 gene.NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation...
, BCL6
BCL6
B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene.- Function :The protein encoded by this gene is an evolutionarily conserved zinc finger transcription factor and contains an N-terminal POZ/BTB domain...
and SPI1
SPI1
Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.-Interactions:SPI1 has been shown to interact with NONO, GATA2, FUS and IRF4.-See also:*Invasion gene associated RNA , a ncRNA located in the SPI-1 region...
.