Hrayr Shahinian
Encyclopedia
Dr. Hrayr Shahinian is a skull base surgeon and founder of the Skull Base Institute. He is a pioneer in microsurgical techniques of the brain. He pioneered new methods of introducing surgical microinstruments into the brain through the skull base to remove tumors and perform other neurosurgical procedures. He completed his undergraduate studies at the American University of Beirut
American University of Beirut
The American University of Beirut is a private, independent university in Beirut, Lebanon. It was founded as the Syrian Protestant College by American missionaries in 1866...

 and completed his medical school at Pritzker School of Medicine at the University of Chicago
University of Chicago
The University of Chicago is a private research university in Chicago, Illinois, USA. It was founded by the American Baptist Education Society with a donation from oil magnate and philanthropist John D. Rockefeller and incorporated in 1890...

. He completed his residency at the Vanderbilt University
Vanderbilt University
Vanderbilt University is a private research university located in Nashville, Tennessee, United States. Founded in 1873, the university is named for shipping and rail magnate "Commodore" Cornelius Vanderbilt, who provided Vanderbilt its initial $1 million endowment despite having never been to the...

http://.www.skullbaseinstitute.com. He is the senior author of the textbook: Endoscopic Skull Base Surgery published by Humana Press. He is currently collaborating with NASA's Jet Propulsion Laboratory on innovating the next generation of endoscopic skull base and brain instruments.

Post-Graduate Training

Fellow, Craniofacial Surgery, Department of Surgery, Instit
ute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY, 1994.

Fellow, Skull Base Surgery, Department of Head and Neck Surgery, University of Zurich, Zurich, Switzerland, 1993-1994.

Fellow, Plastic and Reconstructive Surgery, Department of Surgery, Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY, 1991-1993.

Resident, General Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, 1986-1991.

Research Associate Department of Surgery The University of Chicago, Chicago, IL, 1985-1986.


Degrees

Faculty of Medicine, The American University of Beirut, Beirut, Lebanon.

Pritzker Medical School, The University of Chicago, Chicago, IL, 1985, Doctor of Medicine with Distinction, Dean’s Honor List, Med. I, II, III, IV.

Faculty of Arts and Sciences, The American University of Beirut, Beirut, Lebanon, June 1981, Bachelor of Science with Distinction, Dean’s Honor List 1979, 1980, 1981.

Professional Experience


Director, Cedars-Sinai Skull Base Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 1996-2004.

Co-Director, The Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, CA, 1996-2004.

Director, Skull Base Institute, State University of New York, Stony Brook, NY, 1995-1996.

Co-Director, Skull Base Institute, State University of New York, Stony Brook, NY, 1994
Chief of Service, Division of Skull Base Surgery, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, 1996-2004.

Assistant Professor of Surgery and Neurosurgery, Departments of Surgery and Neurosurgery, State University of New York, Stony Brook, NY, 1994-1996.

Assistant Clinical Professor, Institute of Reconstructive Plastic Surgery, Department of Surgery , New York University Medical Center, New York, NY, 1994-1996.

Attending Surgeon, Department of Surgery, United States Department of Veterans Affairs Medical Center, Northport, NY, 1994-1996.

Published Peer-Reviewed Journal Articles

1. Michelassi F, Shahinian HK, Ferguson MK: Effects of Leukotrienes B4, C4 and D4 on rat mesenteric microcirculation. Journal of Surgical Research 42:703-707, 1987.

2. Ramadan HH, Hamdan US, Samara MA, Shahinian HK: Penetrating neck injuries during the Lebanese War: AUBMC experience Laryngoscope 97(8 pt 1):975-977,1987.

3. Shahinian HK, Ferguson MK, Michelassi F: Effects of histamine and histamine receptor antagonists on rat mesenteric microcirculation. Journal of Surgical Research 42:73-707, 1987.

4. Ferguson MK, Shahinian HK, Michelassi F: Lymphatic smooth muscle responses to Leurkotriene, histamine and platelet activating factor. Journal of Surgical Research 44: 172-177, 1988.

5. Shahinian HK, Sciadini M, Stinger D, Reynolds V: Tubular Adenoma of the main pancreatic duct. Archives of Surgery 12(10):1254-1255, 1992.

6. Biro P, Shahinian HK: Management of difficult intubation caused by lingual tonsillar hyperplasia. Anesth. Analg 79:389-99, 1994.

7. Diasio RB, Lu Z, Zhang R, Shahinian HK: Fluoropyrimidine catabolism. Cancer Treat Research 78:71-93, 1995.

8. Manzione JV, Shahinian HK: Interventional neuroradiology and skull base surgery. The Radiology Letter 1-3, 1995.

9. Shahinian HK, Dornier C, Fisch U: Parapharyngeal space tumors: The infratemporal fossa approach. Skull Base Surgery 2(5):73-81, 1995.

10. Zhang R, Yan J, Shahinian HK, Amin G, Lu Z, Liu T, Saag MS, Jiang Z, Temsamani J, Martin RR: Pharmacokinetics of an anti-human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV-infected subjects. Clin Pharmacol Ther 58(1):44-53, 1995.

11. Shahinian HK, Jaekle R, Suh RH, Jarrahy R, Aguilar VC, Soojian M: Obstetrical factors, governing the etiopathogenesis of lamboid syntosis. Am J. Perinato 15(5):281-6, 1998.

12. Shahinian HK, Suh RH, Jarrahy R: Combined infratemporal fossa and transfacial approach to excising massive tumors. ENT Journal 78(5):350,356, 1999.

13. Jarrahy R, Suh R, Berci G, Shahinian HK: Endoscopic pituitary surgery: An in vivo model for transnasal transsphenoidal hypophysectomy. J Lap & Adv Surg Tech 9(2):211-21, 1999.

14. Jarrahy R, Suh R, Shahinian HK: Viability and functionality of human fetal pituitary cells transplanted into hypophysectomized rats. Skull Base Surgery 9(Sup.1):15-16, 1999.

15. Jarrahy R, Young J, Berci G, Shahinian HK: Endoscopic skull base surgery I: A new animal model for pituitary surgery. J Invest Surg 12:1-6, 1999.

16. Jarrahy R, Young J, Berci G, Shahinian HK: Endoscopic skull base surgery II: A new animal model for surgery of the posterior fossa. J Invest Surg 12:335-339, 1999.

17. Levine JP, Bradley JP, Longaker MT, Shahinian HK: Nasal expansion in the fetal lamb: A first step toward management of cleft nasal deformity in utero. Plastic & Reconstructive Surgery. 103(3):761-7, 1999.

18. Mathiasen RA, Jarrahy R, Cha ST, Bonert VK, Shahinian HK: Pituitary Lymphoma: A case report and literature review. Pituitary 4:283-287, 1999.

19. Bradly JP, Shahinian HK, Levine JP, Rowe NM, Longaker MT: Growth restriction of cranial sutures in the fetal lamb causes deformational changes, not craniosynostosis. Plastic Reconstr. Surg 105:2416-23, 2000.

20. Cha ST, Mathiasen RA, Jarrahy R, Suh R, Shahinian HK: Cerebellopontine angle metastasis from papillary carcinoma of the thyroid: case report and literature review. Surgical Neurology. 54(4):320-326, 2000.

21. Jarrahy R, Berci G, Shahinian HK: Assessment of the efficacy of endoscopy in pituitary adenoma resection. Otolaryngology – Head and Neck Surgery. 126(12):1487-1490, 2000.

22. Jarrahy R, Berci G, Shahinian HK: Endoscope-assisted microvascular decompression of the trigeminal nerve. Otolaryngology - Head & Neck Surgery. 123(3):218-23, 2000.

23. Jarrahy R, Cha ST, Berci G, Shahinian HK: Endoscopic transglabellar approach to the anterior fossa and paranasal sinuses. J Craniofac Surg. 11(5):412-7, 2000.

24. Jarrahy R, Cha ST, Mathiasen RA, Shahinian HK: Congenital teratoma of the oropharyngeal cavity with intracranial extension: case report and literature review. J Craniofac Surg. 11(2):106-12, 2000.

25. Jarrahy R, Shahinian HK: Surgical Management of Pituitary Tumors. Pituitary. Volume 3, No. 1, pg12, 2000.

26. Maheshwari HG, Prezant TR, Herman-Bonert V, Shahinian HK, Kovacs K, Melmed S: Long-acting peptidomimergic control of gigantism Caused by Pituitary Acidophilic Stem Cell Adenoma. J Clin Endocrinol Metab. 85(9):3409-3416, 2000.

27. Shahinian HK: Minimally invasive procedure offering benefits for tumor treatment. Laparoscopic Surgery Update. 8(11): 121-132, 2000.

28. Eby J, Cha ST, Shahinian HK: Fully endoscopic vascular decompression of the facial nerve for hemifacial spasm. Skull Base Surgery. 11(3):189-196, 2001.

29. Jarrahy R, Cha ST, Shahinian HK: Retained foreign body in the orbit and cavernous sinus with delayed presentation of superior orbital fissure syndrome. J Craniofac Surg. 12(1):82-6, 2001.

30. Mathiasen, RA, Eby JB, Jarrahy R, Marguilies DR, Shahinian HK: A dedicated craniofacial and skull base trauma team improves efficiency and reduces cost. Journal of Surg Research. 97(2):138-143, 2001.

31. Cha ST, Eby JB, Katzen JT, Shahinian HK: Trigeminocardiac reflex: a unique case of recurrent asystole during bilateral trigeminal sensory root rhizotomy. J. Craniomaxillofacial Surg. 14(2): 108-111, 2002.

32. Cha ST, Jarrahy R, Yong W, Eby J, Shahinian HK: Rare symptomatic presentation of eccordosis physaliphora and unique endoscope-assisted surgical management. Minimally Inv. Neurosurg. 45:36-39, 2002.

33. Jarrahy R, Eby JB, Cha ST, Shahinian HK: Fully endoscopic vascular decompression of the trigeminal nerve. Minimally Inv. Neurosurg. 45:32-35, 2002.

34. Jarrahy R, Eby J, Shahinian HK: State of the Art: a new powered endoscope holding arm for endoscopic surgery of the cranial base. Minimally Inv. Neurosurg. 45:189-192, 2002.

35. Jarrahy R, Cha ST, Berci G, Shahinian HK: Fully endoscopic vascular decompression of the glossopharyngeal nerve. J Craniofacial Surg. 13(1):90-95, 2002.

36. Vidal S, Horvath E, Bonert V, Shahinian HK, Kovacs K: Neural transformation in a pituitary corticotroph adenoma. Acta Neuropathol. 104:435-440, 2002.

37. Katzen JT, Jarrahy R, Eby JB, Mathiasen RA, Margulies DR, Shahinian HK: Craniofacial and skull base trauma. Journal of Trauma. 54(5):1026-1034, 2003.

38. Shahinian HK, Eby JB, Ocon M: Fully Endoscopic Excision of Vestibular Schwannomas. Minim. Invas. Neurosurg.47: 329-332, 2004.

39. Zhu Y, Shahinian HK, Hakimian B, Bonert V, Lim S, Heaney A: “Temodar: Novel treatment for pituitary carcinoma.” Case Report, ENDO 2004, New Orleans.

40. Friedman TC, Shahinian HK: Bilateral cerebral aneurysms impinging on the pituitary. Pituitary 7:1-2, 2005.

41. Kabil MS, Jarrahy R, Shahinian HK: The Application of Craniofacial Techniques and Intracranial Endoscopy to Pituitary Surgery. J Craniofac Surg. 16(5):2005.

42. Kabil MS, Shahinian HK: Application of the Supraorbital Endoscopic Approach to Tumors of the Anterior Cranial Base. J Craniofac Surg. 16(6): 1070-1074, November 2005.

43. Kabil MS, Eby JB, Shahinian HK: Fully Endoscopic Transnasal vs. Transseptal Transphenoidal Pituitary Surgery. Neurosurg Q 15(3):2005.

44. Kabil MS, Eby JB, Shahinian HK: Endoscopic Vascular Decompression vs. Microvascular Decompression of the Trigeminal Nerve. Minim. Inv. Neurosurg. 48:4, 2005.

45. Patel PM, Shahinian, HK, Friedman TC: Cushing’s Disease Is Not Necessarily a Progressive and Fatal Disease. Endocrinologist 15(6): 343-344, 2005.

46. Kabil MS, Eby JB, Shahinian HK: Fully Endoscopic Endonasal vs. Transseptal Transsphenoidal Pituitary Surgery. Minim Invasive Neurosurg.; 48(6): 348-354, Dec 2005.

47. Lim S, Shahinian HK, Maya M, Yong W, Heaney PA: Temozolomide: A Novel Treatment for Pituitary Carcinomas. The Lancet Oncology 7: 518-20 June 2006.

48. Kabil MS, Shahinian HK: The Endoscopic Supraorbital Approach to Tumors of the Middle Cranial Base. 66(4):396-401; discussion 40, 2006.

49. Kabil MS, Shahinian HK: A Fully Endoscopic Supraorbital Suprafrontal Approach to Frontal and Frontoparietal Convexity/Parasagittal Meningiomas. Neurosurgery Q. 16(4):177-182, 2006.

50. Kabil MS, Shahinian HK: A Series of 112 Fully Endoscopic Resections of Vestibular Schwannomas. Minim. Inv. Neurosurg; 49(6): 362-368, Dec 2006.

51. Friedman TC, Zuckerbraun E, Lee ML, Kabil MS, Shahinian HK: Dynamic Pituitary MRI Has High Sensitivity and Specificity for the Diagnosis of Mild Cushing’s Syndrome and Should be Part of the Initial Workup. Horm Metab Res; 39: 451-456, 2007.

52. Kabil MS, Shahinian HK: "Fully endoscopic supraorbital resection of congenital middle cranial fossa arachnoid cysts: a report of 2 cases" Pediatric Neurosurgery, Vol. 43, No. 4, pp 316 - 322 , 2007.

53. Yuen K, Cook D, Sahasranam P, Patel P, Ghods D, Shahinian HK, Friedman T: “Prevalence of GH and other anterior pituitary hormone deficiencies in adults with nonsecreting pituitary microadenomas and normal serum IGF-1 levels.” Clinical Endocrinology 69: 292-298, 2008.

54. Manohara H, Liao A, Bae Y, Shahinian HK: “Multi-Angle and Rear Viewing Endoscopic tool, (MARVEL).” CALTECH tech brief NTR #45579.

55. Manohara H, Bae SY, Shahinian HK: “Stereo Imaging Miniature Endoscope with Single Chip and Conjugated Multi-bandpass Filters.” CALTECH tech brief NTR.

56. Bae SY, Page N, Wrigley C, Mouroulis P, Liao A, Cunningham T, Shahinian HK, Manohara H: “Miniature HD Stereo-Endoscope and Smart Tools for Minimally Invasive Skull Base Surgeries.” NASA Journal, April 14, 2010.

57. Bae SY, Manohara H, White V, Shcheglov KV, Shahinian HK: "Stereo Imaging Miniature Endoscop." NASA's Jet Propulsion Laboratory Tech Brief, June 1, 2010

58. Kowalczyk R, Bae SY, Korniski R, Shahinian HK, Manohara H: “Advanced Miniaturized Robotic Surgical Instruments: MARVEL; Multi-Axis Rear Viewing Endoscopic tooL.” National Aeronautics and Space Administration Tech Brief, July 6, 2010.

59. Bae SY, Kovniski R, Kowalczyk R, Shahinian HK, Manohara H: “ 3-D Stereoscopic Endoscope Using Conjugate Multiband Filter Technique.” National Aeronautics and Space Administration Tech Brief, July 6, 2010.

Published Book Chapters

60. Shahinian HK: “Tumors and Surgery of the Skull Base”. In: Aston S, Beasley R, Thorne C, Grabb and Smith’s Plastic Surgery. 5th ed. Boston: Little Brown & Company. Chap 39: 459-462, 1997.

61. Jarrahy R, Shahinian HK: “Surgical Management of Pituitary Tumors”. In: DeGroot LJ, Jameson JL, eds. Endocrinology. 4th ed. Philadelphia: W.B. Saunders Co. Chap 26:343-353, 2000.

62. Katzen JT, Eby JB, Evans NE, Shahinian HK: Surgical correction of the acromegalic face. In: Ezzat S, Knutzen R, editors. The Pituitary Patient Resource Guide. 3rd ed. pp. 97, 2001.

63. Jarrahy R, Eby J, Shahinian HK: Pituitary Surgery: The Evolution from Open Transcranial to Fully Endoscopic Transnasal Surgery of the Pituitary Gland. In: Ezzat S, Knutzen R, editors. The Pituitary Patient Resource Guide. 3rd ed. pp. 181-185, 2001.

64. Shahinian HK: “The Skull Base”. In: Current Therapy in Plastic Surgery. McCarthy J, Galiano R, Boutros S, eds. Pp 176-183.

65. Kabil MS, Shahinian HK: “Pituitary Surgery: The Evolution from Open Transcranial to Fully Endoscopic Transnasal Surgery, and Beyond” In: Ezzat S, Knutzen R, editors. The Pituitary Patient Resource Guide. 4th ed. pp. 252 - 258, 2006.

66. Katzen JT, Kabil MS, Shahinian, HK: Surgical Correction of the Acromegalic Face. In: Ezzat S, Knutzen R, editors. The Pituitary Patient Resource Guide. 4th ed. pp. 129 - 132, 2006.

67. Shahinian HK: Skull Base Surgery. In: Thorne C, Beasley R, Aston S, et al Grabb and Smith’s Plastic Surgery. 6th ed. Lippincott, Williams & Wilkins.

68. Jarrahy R, Shahinian, HK: “The Evolution from the Open Craniotomy to Fully Endoscopic Skull Base Surgery” In: Endoscopic Skull Base Surgery, 2008.

69. Tanman R, Shahinian HK: “Anesthetic Considerations in Endoscopic Skull Base Surgery” In: Endoscopic Skull Base Surgery, 2008.

70. Friedman T, Shahinian HK: “Neuroendocrine Aspects of Skull Base Surgery” In: Endoscopic Skull Base Surgery, 2008.

71. Chapot R, El-Serwi A, Shahinian HK: “Interventional Neuroradiology Aspects of Skull Base Surgery” In: Endoscopic Skull Base Surgery, 2008.

72. Kabil MS, Shahinian HK: “Instrumentation in Endoscopic Skull Base Surgery” In: Endoscopic Skull Base Surgery, 2008.

73. Jarrahy R, Kabil MS, Shahinian HK: “The Fully Endoscopic Endonasal Approach” In: Endoscopic Skull Base Surgery, 2008.

74. Jarrahy R, Kabil MS, Shahinian HK: “The Fully Endoscopic Transglabellar Approach” In: Endoscopic Skull Base Surgery, 2008.

75. Kabil MS, Jarrahy R, Shahinian HK: “The Fully Endoscopic Supraorbital Approach” In: Endoscopic Skull Base Surgery, 2008.

76. Kabil MS, Thill MP, Shahinian HK: “The Fully Endoscopic Retrosigmoid Approach” In: Endoscopic Skull Base Surgery, 2008.

77. Kabil MS, Thill MP, Shahinian HK: The Fully Endoscopic Subtemporal Approach” In: Endoscopic Skull Base Surgery, 2008.
Published Textbooks

78. Endoscopic Skull Base Surgery; A Guide with Illustrative Cases, Author: Hrayr K. Shahinian, MD, FACS, Humana Press, Totowa, NJ., January, 2008.
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