Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor

Morphogen

A morphogen is a substance governing the pattern of tissue development, and the positions of the various specialized cell types within a tissue...

. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells

Haematopoiesis

Haematopoiesis is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells...

. It has been shown to have a major role in embryonic organ development, in adult organ regeneration and in wound healing.

Interactions

Hepatocyte growth factor has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with C-Met

C-MET

c-Met is a proto-oncogene that encodes a protein known as hepatocyte growth factor receptor . The hepatocyte growth factor receptor protein possesses tyrosine-kinase activity...

.

Further reading

External links

• Hepatocyte growth factor on the Atlas of Genetics and Oncology
  Atlas of Genetics and Cytogenetics in Oncology and Haematology
  The Atlas of Genetics and Cytogenetics in Oncology and Haematology is a collection of resources on genes, chromosomes anomalies, leukemias, solid tumours, and cancer-prone diseases...