Hepatitis C virus (HCV) cis-acting replication element (CRE)
Encyclopedia
The Hepatitis C virus cis-acting replication element (CRE) is an RNA element
which is found in the coding region of the RNA-dependent RNA polymerase
NS5B. Mutations in this family have been found to cause a blockage in RNA replication and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.
Cis-regulatory element
A cis-regulatory element or cis-element is a region of DNA or RNA that regulates the expression of genes located on that same molecule of DNA . This term is constructed from the Latin word cis, which means "on the same side as". These cis-regulatory elements are often binding sites for one or...
which is found in the coding region of the RNA-dependent RNA polymerase
RNA-dependent RNA polymerase
RNA-dependent RNA polymerase , , or RNA replicase, is an enzyme that catalyzes the replication of RNA from an RNA template...
NS5B. Mutations in this family have been found to cause a blockage in RNA replication and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.
See also
- Hepatitis C alternative reading frame stem-loopHepatitis C alternative reading frame stem-loopHepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the Hepatitis C virus which is proposed to have an important role in regulating translation and repression of the viral genome....
- Hepatitis C virus 3'X elementHepatitis C virus 3'X elementThe Hepatitis C virus 3'X element is an RNA element which contains three stem-loop structures that are essential for replication.-See also:*Hepatitis C alternative reading frame stem-loop*Hepatitis C virus cis-acting replication element...
- Hepatitis C virus stem-loop VIIHepatitis C virus stem-loop VIIHepatitis C virus stem-loop VII is a regulatory element found in the coding region of the RNA-dependent RNA polymerase gene, NS5B. Similarly to stem-loop IV, the stem-loop structure is important for colony formation, though its exact function and mechanism are unknown.-See also:*Hepatitis C...
- Hepatitis C stem-loop IVHepatitis C stem-loop IVThe Hepatitis C stem-loop IV is part of a putative RNA element found in the NS5B coding region. This element along with stem-loop VII, is important for colony formation, though its exact function and mechanism are unknown.-See also:...