HLA-B70
Encyclopedia
HLA-B (alpha)-β2MG with bound peptide
Alleles *1503, *1509, *1510,
*1518, *1529, *1537
Structure (See HLA-B
HLA-B
HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...

)
Shared data
Locus
Locus (genetics)
In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...

chr.6
Chromosome 6 (human)
Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...

 6p21.31

HLA-B70 (B70) is an HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-B
HLA-B
HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...

 serotype
Serotype
Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...

. The serotype identifies certain B*15 gene-allele protein products of HLA-B.
B70 is one of many split antigens of the broad antigen, B15
HLA-B15
HLA-B15 is an HLA-B serotype. The serotype identifies the B*15 gene-allele protein products of HLA-B.B15 is a broad antigen can be subdivided into several split antigens that are often used in characterization. These are B62, B63, B70, B71, B72, B75, B76, B77...

.

Serotype

Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77 recognition of the
HLA B*15 gene products
B*15 B15 B62 B63 B70 B71 B72 B75 B76 B77 Sample
allele % % % % % % % % % size (N)
1 61 10 2569
53 65
1 49 2 2 1 1204
51 3 552
19 21
30 34
Alleles link-out to IMGT/HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

 Databease at EBI
European Bioinformatics Institute
The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...




Alleles

HLA B*1503 frequencies
freq
ref. Population (%)
Burkina Faso Rimaibe 13.8
Guinea Bissau 10.8
Cameroon Pygmy Baka 10.0
South Africian Natal Zulu 9.5
Kenya Luo 8.9
Ivory Coast Akan Adiopodoume 8.0
Kenya Nandi 7.9
Cameroon Sawa 7.7
Zimbabwe Harare Shona 7.7
USA African America 7.3
Burkina Faso Fulani 7.1
Mali Bandiagara 6.9
Senegal Niokholo Mandenka 6.9
Cape Verde SE Islands 6.5
Kenya 6.3
Uganda Kampala 6.2
Sudanese 6.0
Zambia Lusaka 5.7
Cameroon Yaounde 4.9
Cape Verde NW Islands 4.8
Oman 4.7
Cameroon Bamileke 4.5
Tunisia Tunis 4.5
Cameroon Beti 3.7
Brazil Belo Horizonte 3.2
Azores Terceira Island 2.4
Madeira 2.2
Saudi Arabia Guraiat and Hail 2.0
Tunisia 2.0
United Arab Emerates 1.5
Brazil 1.4
Cuban White 1.4
Morocco Nador Metalsa 1.4
Mexico Mestizos 1.2
Italy Bergamo 1.1
Portugal North 1.1
American Samoa 1.0
Iran Baloch 1.0
Mexico Guadalajara Mestizos (2) 1.0
Azores Central Islands 0.9
Israel Ashk. and Non-Ashk. Jews 0.9
Taiwan Hakka 0.9
Croatia 0.7


HLA B*1509 frequencies
freq
ref. Population (%)
Burkina Faso Fulani 4.1
India West Coast Parsis 3.0
Spain Eastern Andalusia Gipsy 3.0
Mexico Mestizos 2.4
Italy South Campania 1.2
Burkina Faso Rimaibe 1.1
China Inner Mongolia 1.0
Mali Bandiagara 0.7
Czech Republic 0.5


HLA B*1510 frequencies
freq
ref. Population (%)
South Africian Natal Zulu 8.5
Zimbabwe Harare Shona 8.4
Ivory Coast Akan Adiopodoume 5.7
Kenya 5.2
Zambia Lusaka 4.6
Cameroon Sawa 3.8
Guinea Bissau 3.8
Kenya Luo 3.6
Senegal Niokholo Mandenka 3.2
Cameroon Beti 2.8
USA African Americans (3) 2.7
Uganda Kampala 2.5
Mexico Mestizos 2.4
Mali Bandiagara 2.2
Kenya Nandi 1.7
Brazil Belo Horizonte 1.6
Cameroon Bamileke 1.3
Cuban Mulatto 1.2
Cameroon Yaounde 1.1
Iran Baloch 1.0
Sudanese 1.0
Tunisia 1.0
Brazil Terena 0.9
Cape Verde NW Islands 0.8
United Arab Emerates 0.8
USA North American Natives 0.8
Guadalajara Mestizos (2) 0.5


HLA B*1518 frequencies
freq
ref. Population (%)
South Africa Natal Tamil 4.1
Autonomous Tibetans 3.8
India Mumbai Marathas 3.7
China North Han 2.9
USA Hawaii Okinawa 2.9
China Guangzhou Han 2.4
India Andhra Pradesh Golla 2.4
China Beijing 2.3
Taiwan Hakka 1.8
Japan 1.7
India North Delhi 1.6
China Inner Mongolia 1.5
China Qinghai Hui 1.4
Czech Republic 1.4
China Yunnan Nu 1.3
Shijiazhuang Tianjian Han 1.1
Ivory Coast Akan Adiopodoume 1.1
Senegal Niokholo Mandenka 1.1
Zambia Lusaka 1.1
Portugal Centre 1.0
Singapore Javanese Indonesians 1.0
Thailand (3) 1.0
South Korea (3) 0.9
Cape Verde Islands 0.8
France South East 0.8
Guinea Bissau 0.8
China South Han 0.7
China Yunnan Lisu 0.7
Russia Tuva (2) 0.6
Singapore Chinese Han 0.6
Spain Eastern Andalusia 0.6
The source of this article is wikipedia, the free encyclopedia.  The text of this article is licensed under the GFDL.
 
x
OK