Guanylate cyclase-coupled receptor
Encyclopedia
Guanylate cyclase-coupled receptor or Membrane-bound guanylyl cyclase is a single transmembrane protein.
They are enzyme-linked receptor
s:
There is also a human pseudogene
for GUCY2GP.
They are enzyme-linked receptor
Enzyme-linked receptor
An enzyme-linked receptor is a transmembrane receptor, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side.These are found in all living species....
s:
- GC-A (NPR1NPR1Natriuretic peptide receptor A/guanylate cyclase A , also known as NPR1, is an atrial natriuretic peptide receptor...
/GUCY2A) & GC-B (NPR2NPR2Natriuretic peptide receptor B/guanylate cyclase B , also known as NPR2, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR2 gene.-External links:...
/GUCY2B): for natriuretic factors such as atrial natriuretic factor (ANF). - GC-C (GUCY2CGuanylyl cyclase cGuanylate cyclase 2C, also known as guanylyl cyclase C , intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor is an enzyme that in humans is encoded by the GUCY2C gene....
): for guanylinGuanylinGuanylin is a 15 amino acid polypeptide that is secreted by goblet cells in the colon. Guanylin acts as an agonist of the guanylyl cyclase receptor GC-C and regulates electrolyte and water transport in intestinal and renal epithelia...
and uroguanylinUroguanylinUroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor GC-C and regulates electrolyte and water transport in intestinal and renal epithelia.In humans, the...
. - GC-D (GUCY2DGUCY2DGUCY2D is a guanylate cyclase associated with type 1 Leber's congenital amaurosis.-References:...
) - GC-E (GUCY2E)
- GC-F (GUCY2F)
There is also a human pseudogene
Pseudogene
Pseudogenes are dysfunctional relatives of known genes that have lost their protein-coding ability or are otherwise no longer expressed in the cell...
for GUCY2GP.