George Q. Daley
Encyclopedia
George Q. Daley, M.D., Ph.D. is the Samuel E. Lux IV Professor of Hematology
/Oncology and the Director of the Stem Cell Transplantation Program at Children’s Hospital Boston. He is also Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School
, an investigator of the Howard Hughes Medical Institute
, Associate Director of Children’s Stem Cell Program, a member of the Executive Committee of the Harvard Stem Cell Institute, and past-President of the International Society for Stem Cell Research (2007–2008).
Dr. Daley's research seeks to translate insights in stem cell
biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered mouse and human cell culture-based models of human blood disease and cancer. Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch
), the differentiation of germ cells from embryonic stem cells (cited as a "Top Ten Breakthrough" by Science magazine
in 2003)
, and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the "Breakthrough of the Year" issue of Science magazine in 2008).
As a graduate student working with Nobelist Dr. David Baltimore
, Dr. Daley demonstrated that the BCR/ABL oncogene induces chronic myeloid leukemia (CML) in a mouse model, which validated BCR/ABL as a target for drug blockade and encouraged the development of imatinib (GleevecTM; Novartis), a revolutionary magic-bullet chemotherapy that induces remissions in virtually every CML patient. Dr. Daley’s recent studies have clarified mechanisms of Gleevec resistance and informed novel combination chemotherapeutic regimens.
Dr. Daley received his bachelor's degree magna cum laude from Harvard University
(1982), a Ph.D. in biology
from MIT (1989), and the M.D. from Harvard Medical School
, where he was only the twelfth individual in the school’s history to be awarded the degree summa cum laude (1991). He served as Chief Resident in Internal Medicine at the Massachusetts General Hospital
and is currently a staff physician in Hematology/Oncology at Children's Hospital Boston
and Dana Farber Cancer Institute in Boston, MA.
He has been elected a fellow of the American Association for the Advancement of Science
and the American Academy of Arts and Sciences
, and a member of the Institute of Medicine of the National Academies, American Society for Clinical Investigation
, American Association of Physicians and American Pediatric Societies. Dr. Daley was an inaugural winner of the NIH Director’s Pioneer Award (2004), which provides a five year unrestricted grant to pursue highly innovative research, and received the Judson Daland Prize from the American Philosophical Society
for achievement in patient-oriented research,, the E. Mead Johnson Award from the American Pediatric Society
for contributions to stem cell research, and the E. Donnall Thomas Prize from the American Society of Hematology
for advances in induced pluripotent stem cell research, in addition to awards recognizing his contributions to medical research from the National Institutes of Health
, the New England Cancer Society, Harvard Medical School
, and the Leukemia and Lymphoma Society of America. In addition to funding by the NIH, Dr. Daley's research has been supported by the National Science Foundation, Defense Advanced Research Projects Agency, American Cancer Society, Edward Mallinckrodt, Jr. Foundation, Burroughs Wellcome Fund, Leukemia and Lymphoma Society of America, Roche Foundation for Anemia Research, Alex's Lemonade Stand, Ellison Medical Foundation, and Doris Duke Medical Foundation.
Dr. Daley has been an international leader in advocating for responsible ethical oversight of human stem cell research. On behalf of the International Society for Stem Cell Research (ISSCR), he chaired the special international task force that formulated the ISSCR Guidelines for Human Embryonic Stem Cell Research (2007) and as president of the ISSCR empaneled and served on the special task force that wrote the ISSCR Guidelines for Clinical Translation of Stem Cells (2008), which have served as a roadmap for advancing stem cell science into clinical trials. Dr. Daley has testified at least six times before committees of the United States Senate
and United States House of Representatives
to advocate for expanded governmental support for stem cell research. He has served on the scientific advisory board of the Massachusetts Life Sciences Center and on the editorial board of the journals Science, Cell, Cell Stem Cell, Stem Cells, and Blood.
Hematology
Hematology, also spelled haematology , is the branch of biology physiology, internal medicine, pathology, clinical laboratory work, and pediatrics that is concerned with the study of blood, the blood-forming organs, and blood diseases...
/Oncology and the Director of the Stem Cell Transplantation Program at Children’s Hospital Boston. He is also Professor in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
, an investigator of the Howard Hughes Medical Institute
Howard Hughes Medical Institute
Howard Hughes Medical Institute is a United States non-profit medical research organization based in Chevy Chase, Maryland. It was founded by the American businessman Howard Hughes in 1953. It is one of the largest private funding organizations for biological and medical research in the United...
, Associate Director of Children’s Stem Cell Program, a member of the Executive Committee of the Harvard Stem Cell Institute, and past-President of the International Society for Stem Cell Research (2007–2008).
Dr. Daley's research seeks to translate insights in stem cell
Stem cell
This article is about the cell type. For the medical therapy, see Stem Cell TreatmentsStem cells are biological cells found in all multicellular organisms, that can divide and differentiate into diverse specialized cell types and can self-renew to produce more stem cells...
biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered mouse and human cell culture-based models of human blood disease and cancer. Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with Rudolf Jaenisch
Rudolf Jaenisch
Rudolf Jaenisch is a biologist at MIT. He is a pioneer of transgenic science, in which an animal’s genetic makeup is altered. Jaenisch has focused on creating transgenic mice to study cancer and neurological diseases....
), the differentiation of germ cells from embryonic stem cells (cited as a "Top Ten Breakthrough" by Science magazine
Science Magazine
Science Magazine was a half-hour television show produced by the Canadian Broadcasting Corporation from 1975 to 1979.The show was hosted by geneticist David Suzuki, who previously hosted the daytime youth programme Suzuki On Science...
in 2003)
, and the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the "Breakthrough of the Year" issue of Science magazine in 2008).
As a graduate student working with Nobelist Dr. David Baltimore
David Baltimore
David Baltimore is an American biologist, university administrator, and Nobel laureate in Physiology or Medicine. He served as president of the California Institute of Technology from 1997 to 2006, and is currently the Robert A. Millikan Professor of Biology at Caltech...
, Dr. Daley demonstrated that the BCR/ABL oncogene induces chronic myeloid leukemia (CML) in a mouse model, which validated BCR/ABL as a target for drug blockade and encouraged the development of imatinib (GleevecTM; Novartis), a revolutionary magic-bullet chemotherapy that induces remissions in virtually every CML patient. Dr. Daley’s recent studies have clarified mechanisms of Gleevec resistance and informed novel combination chemotherapeutic regimens.
Dr. Daley received his bachelor's degree magna cum laude from Harvard University
Harvard University
Harvard University is a private Ivy League university located in Cambridge, Massachusetts, United States, established in 1636 by the Massachusetts legislature. Harvard is the oldest institution of higher learning in the United States and the first corporation chartered in the country...
(1982), a Ph.D. in biology
Biology
Biology is a natural science concerned with the study of life and living organisms, including their structure, function, growth, origin, evolution, distribution, and taxonomy. Biology is a vast subject containing many subdivisions, topics, and disciplines...
from MIT (1989), and the M.D. from Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
, where he was only the twelfth individual in the school’s history to be awarded the degree summa cum laude (1991). He served as Chief Resident in Internal Medicine at the Massachusetts General Hospital
Massachusetts General Hospital
Massachusetts General Hospital is a teaching hospital and biomedical research facility in the West End neighborhood of Boston, Massachusetts...
and is currently a staff physician in Hematology/Oncology at Children's Hospital Boston
Children's Hospital Boston
Children's Hospital Boston is a 396-licensed bed children's hospital in the Longwood Medical and Academic Area of Boston, Massachusetts.At 300 Longwood Avenue, Children's is adjacent both to its teaching affiliate, Harvard Medical School, and to Dana-Farber Cancer Institute...
and Dana Farber Cancer Institute in Boston, MA.
He has been elected a fellow of the American Association for the Advancement of Science
American Association for the Advancement of Science
The American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the...
and the American Academy of Arts and Sciences
American Academy of Arts and Sciences
The American Academy of Arts and Sciences is an independent policy research center that conducts multidisciplinary studies of complex and emerging problems. The Academy’s elected members are leaders in the academic disciplines, the arts, business, and public affairs.James Bowdoin, John Adams, and...
, and a member of the Institute of Medicine of the National Academies, American Society for Clinical Investigation
American Society for Clinical Investigation
The American Society for Clinical Investigation, or ASCI, established in 1908, is one of the nation's oldest and most respected medical honor societies.-Organization and Purpose:...
, American Association of Physicians and American Pediatric Societies. Dr. Daley was an inaugural winner of the NIH Director’s Pioneer Award (2004), which provides a five year unrestricted grant to pursue highly innovative research, and received the Judson Daland Prize from the American Philosophical Society
American Philosophical Society
The American Philosophical Society, founded in 1743, and located in Philadelphia, Pa., is an eminent scholarly organization of international reputation, that promotes useful knowledge in the sciences and humanities through excellence in scholarly research, professional meetings, publications,...
for achievement in patient-oriented research,, the E. Mead Johnson Award from the American Pediatric Society
American Pediatric Society
The American Pediatric Society / Society for Pediatric Research are joint professional and advocacy organizations for pediatricians in the United States and Canada....
for contributions to stem cell research, and the E. Donnall Thomas Prize from the American Society of Hematology
American Society of Hematology
The American Society of Hematology is a professional organization representing hematologists. It was founded in 1958. Its annual meeting is held in December of every year and has attracted nearly 20,000 attendees. The society publishes the medical journal Blood, one of the most cited peer-review...
for advances in induced pluripotent stem cell research, in addition to awards recognizing his contributions to medical research from the National Institutes of Health
National Institutes of Health
The National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...
, the New England Cancer Society, Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
, and the Leukemia and Lymphoma Society of America. In addition to funding by the NIH, Dr. Daley's research has been supported by the National Science Foundation, Defense Advanced Research Projects Agency, American Cancer Society, Edward Mallinckrodt, Jr. Foundation, Burroughs Wellcome Fund, Leukemia and Lymphoma Society of America, Roche Foundation for Anemia Research, Alex's Lemonade Stand, Ellison Medical Foundation, and Doris Duke Medical Foundation.
Dr. Daley has been an international leader in advocating for responsible ethical oversight of human stem cell research. On behalf of the International Society for Stem Cell Research (ISSCR), he chaired the special international task force that formulated the ISSCR Guidelines for Human Embryonic Stem Cell Research (2007) and as president of the ISSCR empaneled and served on the special task force that wrote the ISSCR Guidelines for Clinical Translation of Stem Cells (2008), which have served as a roadmap for advancing stem cell science into clinical trials. Dr. Daley has testified at least six times before committees of the United States Senate
United States Senate
The United States Senate is the upper house of the bicameral legislature of the United States, and together with the United States House of Representatives comprises the United States Congress. The composition and powers of the Senate are established in Article One of the U.S. Constitution. Each...
and United States House of Representatives
United States House of Representatives
The United States House of Representatives is one of the two Houses of the United States Congress, the bicameral legislature which also includes the Senate.The composition and powers of the House are established in Article One of the Constitution...
to advocate for expanded governmental support for stem cell research. He has served on the scientific advisory board of the Massachusetts Life Sciences Center and on the editorial board of the journals Science, Cell, Cell Stem Cell, Stem Cells, and Blood.