Gangliosidosis
Encyclopedia
Gangliosidosis is a lipid storage disorder
caused by the accumulation of lipids known as ganglioside
s. There are two distinct genetic causes of the disease. Both are autosomal recessive and affect males and females equally.
Lipid storage disorder
Lipid storage disorders are a group of inherited metabolic disorders in which harmful amounts of lipids accumulate in some of the body’s cells and tissues. People with these disorders either do not produce enough of one of the enzymes needed to metabolize lipids or they produce enzymes that do...
caused by the accumulation of lipids known as ganglioside
Ganglioside
Ganglioside is a molecule composed of a glycosphingolipid with one or more sialic acids linked on the sugar chain. The 60+ known gangliosides differ mainly in the position and number of NANA residues.It is a component of the cell plasma membrane that modulates cell signal transduction events...
s. There are two distinct genetic causes of the disease. Both are autosomal recessive and affect males and females equally.
See also
- Sphingolipidoses#Overview for an overview table, including gangliosidosis