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Extramedullary hematopoiesis

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Extramedullary hematopoiesis

Extramedullary hematopoiesis refers to hematopoiesis occuring outside of the medulla

Medulla

Medulla refers to the middle of something, and derives from the Latin word for 'marrow' .In medicine it refers to either bone marrow, the spinal cord, or more generally, the middle part of a structure ....
of the bone.

In some cases, it may be physiologic. For example, during fetal develoment, hematopoiesis occurs at many different locations, such as the liver

Liver

The liver is a vital organ present in vertebrates and some other animals; it has a wide range of functions, a few of which are detoxification, protein synthesis, and production of biochemicals necessary for digestion....
.

However, it is more frequently associated with pathologic processes. For example, it can be caused by myelofibrosis

Myelofibrosis

Myelofibrosis, also known as myeloid metaplasia, chronic idiopathic myelofibrosis, and primary myelofibrosis, is a disorder of the bone marrow, in which the marrow undergoes fibrosis - replacement by fibrous tissue ....
.

It can sometimes be identified via computed tomography

Computed tomography

Computed tomography is a medical imaging method employing tomography. Geometry Processing is used to generate a stereoscopy of the inside of an object from a large series of two-dimensional X-ray images taken around a single axis of rotation....
.

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Extramedullary hematopoiesis refers to hematopoiesis occuring outside of the medulla

Medulla

Medulla refers to the middle of something, and derives from the Latin word for 'marrow' .In medicine it refers to either bone marrow, the spinal cord, or more generally, the middle part of a structure ....
of the bone.

In some cases, it may be physiologic. For example, during fetal develoment, hematopoiesis occurs at many different locations, such as the liver

Liver

The liver is a vital organ present in vertebrates and some other animals; it has a wide range of functions, a few of which are detoxification, protein synthesis, and production of biochemicals necessary for digestion....
.

However, it is more frequently associated with pathologic processes. For example, it can be caused by myelofibrosis

Myelofibrosis

Myelofibrosis, also known as myeloid metaplasia, chronic idiopathic myelofibrosis, and primary myelofibrosis, is a disorder of the bone marrow, in which the marrow undergoes fibrosis - replacement by fibrous tissue ....
.

It can sometimes be identified via computed tomography

Computed tomography

Computed tomography is a medical imaging method employing tomography. Geometry Processing is used to generate a stereoscopy of the inside of an object from a large series of two-dimensional X-ray images taken around a single axis of rotation....
.

See also

Blueberry muffin baby
Blueberry muffin baby

Blueberry muffin baby is a term used to describe the characteristic distributed purpura due to extramedullary hematopoiesis found in infants.It was originally considered characteristic of rubella, but is now considered to be potentially associated with many other conditions, such as cytomegalovirus....

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