Ductopenia is the histological hallmark of Vanishing Bile Duct Syndrome

Vanishing bile duct syndrome

Vanishing bile duct syndrome is a loose collection of diseases which leads to of the injury to hepatic bile ducts and eventual ductopenia.-Congenital/Developmental:In fetal and neonatal life the ductal plates are remodeled...

.The ductopenia is arbitrarily defined as less than 0.5 bile ducts per portal triad.

The most common cause of Ductopenia is Primary Biliary Cirrhosis.

Other causes of ductopenia include failing Liver

Liver

The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion...

 transplant, Hodgkin

Hodgkin

Hodgkin may refer to:People with the surname Hodgkin who are part of an extended Quaker family:*Alan Lloyd Hodgkin , British physiologist and biophysicist*Dorothy Crowfoot Hodgkin , British chemist*Douglas Hodgkin...

's disease, Graft versus Host Disease (GVHD), Sarcoid, Cytomegalovirus

Cytomegalovirus

Cytomegalovirus is a viral genus of the viral group known as Herpesviridae or herpesviruses. It is typically abbreviated as CMV: The species that infects humans is commonly known as human CMV or human herpesvirus-5 , and is the most studied of all cytomegaloviruses...

 infection, HIV

HIV

Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...

and medication toxocity.