Drotaverine
Encyclopedia
Drotaverine is an antispasmodic
drug, structurally related to papaverine
. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic
effects. Drotaverine has been shown to possess dose-dependant analgesic effects in animal models. One small study has shown drotaverine to be eliminated mainly non-renally.
A few small 2003 studies found drotaverine to be nearly 80% effective in treating renal colic
. It has also been studied in accelerating labor
by speeding up cervical dilation, but the results have been conflicting. Drotaverine has been shown to be effective in paracervical block
in managing pain during hysteroscopy and endometrial biopsy when administered together with mefenamic acid
. IBS
patients presenting with predominant diarrhea
are more likely to benefit from Buscopan. Drotaverin has also been tested in combination with rimantadine
for antiviral activity against A and B type influenza
. Drotaverin has an adverse effects frequency of 0.9%, side effects being relatively uncommon.
Drotaverine in sold under brand name No-Spa (Chinoin Pharmaceutical and Chemical Works, Hungary, a member of the Sanofi-Aventis
).
Antispasmodic
An antispasmodic is a drug or a herb that suppresses muscle spasms.-Smooth muscle spasm:One type of antispasmodics is used for smooth muscle contraction, especially in tubular organs of the gastrointestinal tract...
drug, structurally related to papaverine
Papaverine
Papaverine is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasm, vasospasm , and occasionally in the treatment of erectile dysfunction...
. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic
Anticholinergic
An anticholinergic agent is a substance that blocks the neurotransmitter acetylcholine in the central and the peripheral nervous system. An example of an anticholinergic is dicycloverine, and the classic example is atropine....
effects. Drotaverine has been shown to possess dose-dependant analgesic effects in animal models. One small study has shown drotaverine to be eliminated mainly non-renally.
A few small 2003 studies found drotaverine to be nearly 80% effective in treating renal colic
Renal colic
Renal colic is a type of abdominal pain commonly caused by kidney stones.-Presentation:The pain typically begins in the abdomen and often radiates to the hypochondrium or the groin. The pain is often colicky due to ureteric peristalsis, but may be constant...
. It has also been studied in accelerating labor
Childbirth
Childbirth is the culmination of a human pregnancy or gestation period with the birth of one or more newborn infants from a woman's uterus...
by speeding up cervical dilation, but the results have been conflicting. Drotaverine has been shown to be effective in paracervical block
Paracervical block
A paracervical block is an anesthetic procedure used in obstetrics and gynecology, in which a local anesthetic is injected into between two to six sites at a depth of 3-7 mm alongside the vaginal portion of the cervix in the vaginal fornices....
in managing pain during hysteroscopy and endometrial biopsy when administered together with mefenamic acid
Mefenamic acid
Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid is marketed in the USA as Ponstel....
. IBS
IBS
- Academia :* International Business School, Budapest, a partnership with Oxford Brookes University based in Hungary dating from 1991* International Biometric Society, an academic statistical association for mathematical and statistical methods in the biosciences...
patients presenting with predominant diarrhea
Diarrhea
Diarrhea , also spelled diarrhoea, is the condition of having three or more loose or liquid bowel movements per day. It is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause dehydration and...
are more likely to benefit from Buscopan. Drotaverin has also been tested in combination with rimantadine
Rimantadine
Rimantadine is an orally administered antiviral drug used to treat, and in rare cases prevent, influenzavirus A infection. When taken within one to two days of developing symptoms, rimantadine can shorten the duration and moderate the severity of influenza. Both rimantadine and the similar drug...
for antiviral activity against A and B type influenza
Influenza
Influenza, commonly referred to as the flu, is an infectious disease caused by RNA viruses of the family Orthomyxoviridae , that affects birds and mammals...
. Drotaverin has an adverse effects frequency of 0.9%, side effects being relatively uncommon.
Drotaverine in sold under brand name No-Spa (Chinoin Pharmaceutical and Chemical Works, Hungary, a member of the Sanofi-Aventis
Sanofi-Aventis
Sanofi S.A. is a multinational pharmaceutical company headquartered in Paris, France, the world's fourth-largest by prescription sales. Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical products for sale principally in the prescription market, but the...
).