Diego Colón de Toledo, 4th Admiral of the Indies
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Diego Colón de Toledo y Pravia, 4th Admiral of the Indies (died 28 January 1578) was a paternal grandson of Diego Colón
Diego Colón
Diego Columbus was the 2nd Admiral of the Indies, 2nd Viceroy of the Indies and 3rd Governor of the Indies. He was the firstborn son of Christopher Columbus and wife Filipa Moniz Perestrelo, and was born in 1479/1480 in Porto Santo, Portugal or 1474 in Lisbon, Portugal. He died February...

 and his wife María de Toledo y Rojas., making him a great-grandson of Christopher Columbus
Christopher Columbus
Christopher Columbus was an explorer, colonizer, and navigator, born in the Republic of Genoa, in northwestern Italy. Under the auspices of the Catholic Monarchs of Spain, he completed four voyages across the Atlantic Ocean that led to general European awareness of the American continents in the...

.

He married his first cousin Felipa Colón de Toledo, 2nd Duchess of Veragua, the second daughter and heiress of Luis Colón de Toledo, 1st Duke of Veragua, and his first wife María de Mosquera y Pasamonte, without issue. He held the Almirante de las Índias office in her place, which she had inherited.
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