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Dicumarol
 
 
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Dicoumarol (INN
International Nonproprietary Name

An International Nonproprietary Name is the official non-proprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization ....
) or dicumarol (USAN
United States Adopted Name

United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States. Each name is assigned by the USAN Council, which is co-sponsored by the American Medical Association , the United States Pharmacopeial Convention , and the American Pharmacists Association ....
) is an anticoagulant
Anticoagulant

An anticoagulant is a substance that prevents blood coagulation; that is, it stops blood from clotting. A group of pharmaceuticals called anticoagulants can be used in vivo as a medication for thrombosis disorders....
 that functions as a Vitamin K
Vitamin K

Vitamin K denotes a group of lipophilic, hydrophobic vitamins that are needed for the posttranslational modification of certain proteins, mostly required for blood coagulation....
 antagonist (similar to warfarin
Warfarin

Warfarin is an anticoagulant. It was initially marketed as a pesticide against rats and mice, and is still popular for this purpose, although more potent poisons such as brodifacoum have since been developed....
). It is also used in biochemical experiments as an inhibitor of reductases.

It is a derivative of coumarin
Coumarin

Coumarin is a chemical compound ; a toxin found in many plants, notably in high concentration in the tonka bean, vanilla grass, woodruff, mullein, and bison grass....
.

Mechanism of action : it is a competitive inhibitor of Vitamin K preventing the formation of prothrombin , Administration of Vitamin K is the antidote for dicumarol toxicity






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Dicoumarol (INN
International Nonproprietary Name

An International Nonproprietary Name is the official non-proprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization ....
) or dicumarol (USAN
United States Adopted Name

United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States. Each name is assigned by the USAN Council, which is co-sponsored by the American Medical Association , the United States Pharmacopeial Convention , and the American Pharmacists Association ....
) is an anticoagulant
Anticoagulant

An anticoagulant is a substance that prevents blood coagulation; that is, it stops blood from clotting. A group of pharmaceuticals called anticoagulants can be used in vivo as a medication for thrombosis disorders....
 that functions as a Vitamin K
Vitamin K

Vitamin K denotes a group of lipophilic, hydrophobic vitamins that are needed for the posttranslational modification of certain proteins, mostly required for blood coagulation....
 antagonist (similar to warfarin
Warfarin

Warfarin is an anticoagulant. It was initially marketed as a pesticide against rats and mice, and is still popular for this purpose, although more potent poisons such as brodifacoum have since been developed....
). It is also used in biochemical experiments as an inhibitor of reductases.

It is a derivative of coumarin
Coumarin

Coumarin is a chemical compound ; a toxin found in many plants, notably in high concentration in the tonka bean, vanilla grass, woodruff, mullein, and bison grass....
.

Mechanism of action : it is a competitive inhibitor of Vitamin K preventing the formation of prothrombin , Administration of Vitamin K is the antidote for dicumarol toxicity Follow-up: Done by measuring the Prothrombin time (PT) Uses: Used along with heparin for the treatment of deep venous thrombosis

also that Dicumarol is a chemical subsrance of plant origin given only orally and acts within two days

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