DMT1
Encyclopedia
DMT1 is a transporter involved in human iron metabolism
. It is located on the apical membrane of duodenal enterocytes and transports Fe2+ from the intestinal lumen to the cytosol.
Dietary iron must be reduced from Fe3+ to Fe2+ before being transported by DMT1. This is accomplished by Duodenal cytochrome B
.
Human iron metabolism
Human iron metabolism is the set of chemical reactions maintaining human homeostasis of iron. Iron is an essential element for most life on Earth, including human beings. The control of this necessary but potentially toxic substance is an important part of many aspects of human health and disease...
. It is located on the apical membrane of duodenal enterocytes and transports Fe2+ from the intestinal lumen to the cytosol.
Dietary iron must be reduced from Fe3+ to Fe2+ before being transported by DMT1. This is accomplished by Duodenal cytochrome B
Duodenal cytochrome B
Duodenal cytochrome B has been identified as the reductase enzyme which catalyzes the reduction of Fe3+ to Fe2+ in the process of iron absorption in the duodenum of mammals. According to research carried out, it appears that Dcytb upregulation is controlled by a number of independent stimulators...
.