Critical Assessment of Prediction of Interactions
Encyclopedia
Critical Assessment of Prediction of Interactions (CAPRI) is a community-wide experiment in modelling the molecular structure
of protein complex
es, otherwise known as protein–protein docking.
The CAPRI is an ongoing series of events in which researchers throughout the community attempt to dock the same proteins, as provided by the assessors. Rounds take place about every six months. Each round contains between one and six target protein–protein complexes whose structures have been recently determined experimentally. The coordinates and are held privately by the assessors, with the co-operation of the structural biologist
s who determined them. The CAPRI experiment is double-blind, in the sense that the submittors do not know the solved structure, and the assessors do not know the correspondence between a submission and the identity of its creator.
Molecular geometry
Molecular geometry or molecular structure is the three-dimensional arrangement of the atoms that constitute a molecule. It determines several properties of a substance including its reactivity, polarity, phase of matter, color, magnetism, and biological activity.- Molecular geometry determination...
of protein complex
Protein complex
A multiprotein complex is a group of two or more associated polypeptide chains. If the different polypeptide chains contain different protein domain, the resulting multiprotein complex can have multiple catalytic functions...
es, otherwise known as protein–protein docking.
The CAPRI is an ongoing series of events in which researchers throughout the community attempt to dock the same proteins, as provided by the assessors. Rounds take place about every six months. Each round contains between one and six target protein–protein complexes whose structures have been recently determined experimentally. The coordinates and are held privately by the assessors, with the co-operation of the structural biologist
Structural biology
Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules, especially proteins and nucleic acids, how they acquire the structures they have, and how alterations in their structures affect their function...
s who determined them. The CAPRI experiment is double-blind, in the sense that the submittors do not know the solved structure, and the assessors do not know the correspondence between a submission and the identity of its creator.
List of predictions servers participating in CAPRI
- ClusPro
- GRAMM-X
- FireDock
- HADDOCK — High-Ambiguity-Driven protein–protein DOCKing
- PatchDock
- SKE-DOCK
- SmoothDock
- 3D-Garden — Global and Restrained Docking Exploration Nexus
- TopDown
See also
- Critical Assessment of Techniques for Protein Structure Prediction (CASP) — a similar exercise in the field of protein structure prediction