Crichton-Browne sign
Encyclopedia
Crichton-Browne sign is a clinical sign
Medical sign
A medical sign is an objective indication of some medical fact or characteristic that may be detected by a physician during a physical examination of a patient....

 in which there is twitching of the outer margins of the eyes and mouth. It is an early sign of general paralysis of the insane
General paresis of the insane
General paresis, also known as general paralysis of the insane or paralytic dementia, is a neuropsychiatric disorder affecting the brain and central nervous system, caused by syphilis infection...

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The sign was described by Sir James Crichton-Browne
James Crichton-Browne
Sir James Crichton-Browne MD FRS was a leading British psychiatrist famous for studies on the relationship of mental illness to neurological damage and for the development of public health policies in relation to mental health...

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