Combretastatin A-4
Encyclopedia
Combretastatin A-4 is a combretastatin
, a type of stilbenoid. It can be isolated from Combretum caffrum
, the Eastern Cape South African Bushwillow tree.
, a prodrug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.
Combretastatin
The combretastatins are a class of natural stilbenoid natural phenols. A variety of different natural combretastatin molecules are present in the bark of Combretum caffrum, commonly known as South African Bush Willow...
, a type of stilbenoid. It can be isolated from Combretum caffrum
Combretum caffrum
Combretum caffrum is the Eastern Cape South African Bushwillow tree.-Biochemistry:In C. caffrum, combretastatins A-1, A-4 and B-1 can be found....
, the Eastern Cape South African Bushwillow tree.
Derivatives
Combretastatin A-4 is the active component of combretastatin A-4 phosphateCombretastatin A-4 phosphate
Combretastatin A-4 phosphate is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature of cancer tumors causing central necrosis. It is a derivative of combretastatin.Combretastatin A-4 phosphate is a prodrug. In vivo, it is...
, a prodrug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis.
See also
- OmbrabulinOmbrabulinOmbrabulin is an experimental drug candidate discovered by Ajinomoto and under development by Sanofi-Aventis. It is currently in Phase III clinical trials for the treatment of advanced-stage soft-tissue sarcoma....
, a combretastatin A-4 derivative in clinical trials for treatment of cancer