Collybistin is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 much like gephyrin

Gephyrin

Gephyrin is a protein that is a component of the postsynaptic protein network of inhibitory synapses. Positive antibody staining for gephyrin at a synapse is consistent with the presence of glycine and/or GABA-A receptors. Gephyrin displaces GABA receptors from the GABARAP/P130 complex, then brings...

 which is thought to aid the formation of submembrane gephyrin aggregates that accumulate hetero-oligomeric glycine receptor

Glycine receptor

The glycine receptor, or GlyR, is the receptor for the amino acid neurotransmitter glycine. GlyR is an ionotropic receptor that produces its effects through chloride current...

s. Data from Nature Neuroscience

Nature Neuroscience

Nature Neuroscience is a monthly scientific journal published by Nature Publishing Group. Its focus is original research papers relating specifically to neuroscience and was established in May 1998. According to the Journal Citation Reports, Nature Neuroscience has a 2009 impact factor of 14.345,...

 2000 suggests that the expression of collybistin regulates the membrane

Biological membrane

A biological membrane or biomembrane is an enclosing or separatingmembrane that acts as a selective barrier, within or around a cell. It consists of a lipid bilayer with embedded proteins that may constitute close to 50% of membrane content...

 disposition

Disposition

A disposition is a habit, a preparation, a state of readiness, or a tendency to act in a specified way.The terms dispositional belief and occurrent belief refer, in the former case, to a belief that is held in the mind but not currently being considered, and in the latter case, to a belief that is...

 of gephyrin by activating a GTPase

GTPase

GTPases are a large family of hydrolase enzymes that can bind and hydrolyze guanosine triphosphate . The GTP binding and hydrolysis takes place in the highly conserved G domain common to all GTPases.-Functions:...

 of the Rho/Rac Family. Therefore this protein may be an important determinant of inhibitory postsynaptic membrane formation and plasticity

Plasticity

Plasticity may refer to:Science* Plasticity , in physics and engineering, plasticity is the propensity of a material to undergo permanent deformation under load...

.