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Class I PI 3-kinases
are a subgroup of the enzyme family, phosphoinositide 3-kinase
Phosphatidylinositol 3-kinases are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In response to lipopolysaccharide, PI3K phosphorylates p65, inducing...
that possess a common protein domain structure, substrate specificity, and method of activation. Class I PI 3-kinases are further divided into two subclasses, class IA PI 3-kinases and class IB PI 3-kinases.
Class IA PI 3-kinases
Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs).
There are three catalytic subunits that are classified as class IA PI 3-kinases:
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase or p110δ is an enzyme that in humans is encoded by the PIK3CD gene....
There are currently five regulatory subunits that are known to associate with class IA PI 3-kinases catalytic subunits:
- p85α and p85β
- p55α and p55γ
Class IB PI 3-kinases
Class IB PI 3-kinases are activated by G-protein-coupled receptors (GPCRs).
The only known class IB PI 3-kinase catalytic subunit is p110γ.
There are two known regulatory subunits for p110γ:
Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.-Further reading:...
Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that possess a common protein domain structure, substrate specificity, and method of activation...
p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ.Its also referred to as p84 and p87.- References :1.Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma....