• Carbohydrate sulfotransferases 8 and 9, which transfer sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. They function in the biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures.
• Carbohydrate sulfotransferase 10, which transfers sulfate to position 3 of the terminal glucuronic acid in both protein- and lipid-linked oligosaccharides. It directs the biosynthesis of the HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult.
• Carbohydrate sulfotransferases 11 - 13, which catalyze the transfer of sulfate to position 4 of the GalNAc residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Some, thought not all, of these enzymes also transfer sulfate to dermatan.
• Carbohydrate sulfotransferase D4ST1, which transfers sulfate to position 4 of the GalNAc residue of dermatan sulfate.

Human proteins from this family