CD155 is a Type I transmembrane
glycoproteinGlycoproteins are proteins that contain oligosaccharide chains covalently attached to their polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...
in the immunoglobulin superfamily. Commonly known as
Poliovirus Receptor (PVR) due to its involvement in the cellular
poliovirusPoliovirus, the causative agent of poliomyelitis, is a human enterovirus and member of the family of Picornaviridae. Poliovirus is composed of a RNA genome and a protein capsid. The genome is single-stranded positive-sense RNA genome that is about 7500 nucleotides long. The viral particle is about...
infection in primates, CD155's normal cellular function is in the establishment of intercellular
adherens junctionAdherens junctions are protein complexes that occur at cell-cell junctions in epithelial tissues, usually more basal than tight junctions...
s between epithelial cells. The role of CD155 in the
immune systemAn immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens and tumour cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own...
is unclear, though it may be involved in intestinal
humoral immune responsesThe Humoral Immune Response is the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage . B Cells transform into plasma cells which secrete antibodies...
.
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CD155 is a Type I transmembrane
glycoproteinGlycoproteins are proteins that contain oligosaccharide chains covalently attached to their polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...
in the immunoglobulin superfamily. Commonly known as
Poliovirus Receptor (PVR) due to its involvement in the cellular
poliovirusPoliovirus, the causative agent of poliomyelitis, is a human enterovirus and member of the family of Picornaviridae. Poliovirus is composed of a RNA genome and a protein capsid. The genome is single-stranded positive-sense RNA genome that is about 7500 nucleotides long. The viral particle is about...
infection in primates, CD155's normal cellular function is in the establishment of intercellular
adherens junctionAdherens junctions are protein complexes that occur at cell-cell junctions in epithelial tissues, usually more basal than tight junctions...
s between epithelial cells. The role of CD155 in the
immune systemAn immune system is a system of biological structures and processes within an organism that protects against disease by identifying and killing pathogens and tumour cells. It detects a wide variety of agents, from viruses to parasitic worms, and needs to distinguish them from the organism's own...
is unclear, though it may be involved in intestinal
humoral immune responsesThe Humoral Immune Response is the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage . B Cells transform into plasma cells which secrete antibodies...
.