C-src tyrosine kinase, also known as CSK, is a human protein and gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

. It includes an SH2 domain

SH2 domain

The SH2 domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins...

, an SH3 domain

SH3 domain

The SRC Homology 3 Domain is a small protein domain of about 60 amino acids residues first identified as a conserved sequence in the viral adaptor protein v-Crk and the non-catalytic parts of enzymes such as phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src...

, and a tyrosine kinase

Tyrosine kinase

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions....

 domain. This protein specifically phosphorylates Tyr-504 residue on human leukocyte-specific protein tyrosine kinase

Lck

Lck is a protein that is found inside specialized cells of the immune system called lymphocytes. Lck is a tyrosine kinase, which phosphorylates tyrosine residues of certain proteins involved in the intracellular signaling pathways of these lymphocytes...

, which acts as a negative regulatory site

Regulatory site

A regulatory site is a site on an allosteric protein to which a modulator molecule binds. A ligand-binding site on a receptor or enzyme distinct from the active site. Allosteric modulators alter enzyme activity by binding to the regulatory site. Also known as an "allosteric site"....

. It may also act on the LYN

LYN

Tyrosine-protein kinase Lyn is a protein that in humans is encoded in humans by the LYN gene.Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. In various hematopoietic cells, Lyn has emerged...

 and FYN

FYN

Proto-oncogene tyrosine-protein kinase Fyn is an enzyme that in humans is encoded by the FYN gene.This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth...

 kinases.

Interactions

C-src tyrosine kinase has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with LYP.
YTHDC1

YTHDC1

YTH domain-containing protein 1 is a protein that in humans is encoded by the YTHDC1 gene.-Interactions:YTHDC1 has been shown to interact with Emerin, C-src tyrosine kinase, KHDRBS1 and Abl gene.-Further reading:...

, DAB2

DAB2

Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.-Interactions:DAB2 has been shown to interact with C-src tyrosine kinase, Cdk1, Src, LRP2, DVL3, PIN1, MYO6, DVL2, DAB2IP, Mothers against decapentaplegic homolog 3 and Mothers against decapentaplegic homolog 2.-Further...

, Dystroglycan

Dystroglycan

Dystroglycan is a protein that in humans is encoded by the DAG1 gene.Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in Homo sapiens by chromosome 3. There are two exons that are separated by a large intron...

, Insulin-like growth factor 1 receptor, HNRPK

HNRPK

Heterogeneous nuclear ribonucleoprotein K is a protein that in humans is encoded by the HNRNPK gene.-Interactions:HNRPK has been shown to interact with KHDRBS1, PCBP2, PTBP1, DDX1, PRMT1, HNRNPL and C-src tyrosine kinase.-Further reading:...

, CREB-binding protein and PAG1

PAG1

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.-Interactions:...

.