Brunó Ferenc Straub
Encyclopedia
Brunó Ferenc Straub was a biochemist
Biochemist
Biochemists are scientists who are trained in biochemistry. Typical biochemists study chemical processes and chemical transformations in living organisms. The prefix of "bio" in "biochemist" can be understood as a fusion of "biological chemist."-Role:...

. As a young scholar he was a research assistant of Albert Szent-Györgyi
Albert Szent-Györgyi
Albert Szent-Györgyi de Nagyrápolt was a Hungarian physiologist who won the Nobel Prize in Physiology or Medicine in 1937. He is credited with discovering vitamin C and the components and reactions of the citric acid cycle...

 at the University of Szeged
University of Szeged
The University of Szeged is one of Hungary's most distinguished universities, and is among the most prominent higher education institutions in Central Europe...

, and subsequently worked at the Molteno Institute, Cambridge
Cambridge
The city of Cambridge is a university town and the administrative centre of the county of Cambridgeshire, England. It lies in East Anglia about north of London. Cambridge is at the heart of the high-technology centre known as Silicon Fen – a play on Silicon Valley and the fens surrounding the...

, UK. He discovered actin
Actin
Actin is a globular, roughly 42-kDa moonlighting protein found in all eukaryotic cells where it may be present at concentrations of over 100 μM. It is also one of the most highly-conserved proteins, differing by no more than 20% in species as diverse as algae and humans...

. He founded the Biological Research Centre
Biological Research Centre
The Biological Research Centre of the Hungarian Academy of Sciences is located in Szeged, Hungary. The research center was founded in 1971, created by Brunó F. Straub, who was director until 1977. As of 2011, the director is Dénes Dudits and the deputy director is Ormos Pál...

 in Szeged
Szeged
' is the third largest city of Hungary, the largest city and regional centre of the Southern Great Plain and the county town of Csongrád county. The University of Szeged is one of the most distinguished universities in Hungary....

. He was the Chairman of the Hungarian Presidential Council from June 29, 1988 to October 18, 1989. He himself was never a member of the Communist Party
Communist party
A political party described as a Communist party includes those that advocate the application of the social principles of communism through a communist form of government...

. He proposed the theory of conformational selection
Conformational change
A macromolecule is usually flexible and dynamic. It can change its shape in response to changes in its environment or other factors; each possible shape is called a conformation, and a transition between them is called a conformational change...

 in 1964; the same year the MWC model
MWC model
In biochemistry, the MWC model describes allosteric transitions of proteins made up of identical subunits. It was proposed by Jean-Pierre Changeux based on his PhD experiments, and described by Jacques Monod, Jeffries Wyman, and Jean-Pierre Changeux...

 was proposed.

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