BRCT domain
Encyclopedia
BRCA1 C Terminus domain is a family of evolutionarily related proteins
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The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint
functions responsive to DNA
damage, for example as found in the breast cancer DNA-repair protein BRCA1
. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.
Protein family
A protein family is a group of evolutionarily-related proteins, and is often nearly synonymous with gene family. The term protein family should not be confused with family as it is used in taxonomy....
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The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint
Cell cycle checkpoint
Cell cycle checkpoints are control mechanisms that ensure the fidelity of cell division in eukaryotic cells. These checkpoints verify whether the processes at each phase of the cell cycle have been accurately completed before progression into the next phase...
functions responsive to DNA
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
damage, for example as found in the breast cancer DNA-repair protein BRCA1
BRCA1
BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990...
. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.
Examples
Human proteins containing this domain include:- BARD1BARD1BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene.-Interactions:BARD1 has been shown to interact with BRE, UBE2D1, CSTF2, BRCC3, RAD51, BCL3, TACC1, Ewing sarcoma breakpoint region 1, FANCD2, H2AFX, CSTF1, NPM1, BRCA2, BRCA1, P53 and Aurora B...
; BRCA1BRCA1BRCA1 is a human caretaker gene that produces a protein called breast cancer type 1 susceptibility protein, responsible for repairing DNA. The first evidence for the existence of the gene was provided by the King laboratory at UC Berkeley in 1990... - CTDP1CTDP1RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.-Interactions:CTDP1 has been shown to interact with WD repeat-containing protein 77, GTF2F1 and POLR2A.-Further reading:...
; DNTT - ECT2ECT2Protein ECT2 is a protein that in humans is encoded by the ECT2 gene.-Further reading:...
- LIG4LIG4LIG4 is a human gene that encodes the protein DNA Ligase IV.-Further reading:...
- MCPH1MicrocephalinMicrocephalin is one of six genes causing primary microcephaly when non-functional mutations exist in the homozygous state...
; MDC1MDC1Mediator of DNA damage checkpoint protein 1 is a protein that in humans is encoded by the MDC1 gene.-Interactions:MDC1 has been shown to interact with MRE11A, H2AFX and CHEK2.-Further reading:... - NBNNibrinNibrin, also known as NBN, is a protein which in humans is encoded by the NBN gene.- Function :Nibrin is a protein associated with the repair of double strand breaks which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50 double strand...
- PARP1PARP1Poly [ADP-ribose] polymerase 1 also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene.- Function :PARP1 works:...
; PARP4PARP4Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.-Interactions:PARP4 has been shown to interact with Major vault protein.-Further reading:...
; PAXIP1PAXIP1PAX-interacting protein 1 is a protein that in humans is encoded by the PAXIP1 gene.-Interactions:PAXIP1 has been shown to interact with PAX2 and TP53BP1.-Further reading:...
; PES1PES1Pescadillo homolog is a protein that in humans is encoded by the PES1 gene.-Further reading:... - REV1REV1DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene. Rev1 is a Y family DNA polymerase; it is sometimes referred to as a deoxycytidyl transferase because it only inserts deoxycytidine across from lesions. Whether G, A, T, C, or an abasic site, Rev1 will always add a C...
; RFC1RFC1Replication factor C subunit 1 is a protein that in humans is encoded by the RFC1 gene.-Interactions:RFC1 has been shown to interact with BRD4, HDAC1, RFC3, RELA and PCNA.-Further reading:...
; TOPBP1TOPBP1DNA topoisomerase 2-binding protein 1 is an enzyme that in humans is encoded by the TOPBP1 gene.-Interactions:TOPBP1 has been shown to interact with RAD9A, E2F1, Promyelocytic leukemia protein, ZBTB17 and UBR5.-Further reading:...
; TP53BP1TP53BP1Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.- Clinical significance :53BP1 is underexpressed in most cases of triple-negative breast cancer....
; XRCC1XRCC1XRCC1 is a DNA repair protein.It complexes with DNA ligase III.-Interactions:XRCC1 has been shown to interact with PARP2, DNA polymerase beta, Aprataxin, Oxoguanine glycosylase, PCNA, APEX1, PNKP and PARP1.-Further reading:-External links:...