BHF-177
Encyclopedia
BHF-177 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB
receptor
. It was shown to reduce self-administration of nicotine
in animal studies.
GABA B receptor
GABAB receptors are metabotropic transmembrane receptors for gamma-aminobutyric acid that are linked via G-proteins to potassium channels...
receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
. It was shown to reduce self-administration of nicotine
Nicotine
Nicotine is an alkaloid found in the nightshade family of plants that constitutes approximately 0.6–3.0% of the dry weight of tobacco, with biosynthesis taking place in the roots and accumulation occurring in the leaves...
in animal studies.