BD-1063
Encyclopedia
BD-1063 is a sigma receptor
antagonist, with moderate selectivity for the σ1
subtype. It blocks the effects of MDMA in animal studies, and reduces alcohol intake in animal models of alcoholism
.
Sigma receptor
The sigma receptors σ1 and σ2 bind to ligands such as 4-PPBP, SA 4503, ditolylguanidine, dimethyltryptamine and siramesine.- Classification :...
antagonist, with moderate selectivity for the σ1
Sigma-1 receptor
The sigma-1 receptor is a chaperone protein at the endoplasmatic reticulum that modulates calcium signaling through the IP3 receptor. In humans, the sigma-1 receptor is encoded by the SIGMAR1 gene....
subtype. It blocks the effects of MDMA in animal studies, and reduces alcohol intake in animal models of alcoholism
Alcoholism
Alcoholism is a broad term for problems with alcohol, and is generally used to mean compulsive and uncontrolled consumption of alcoholic beverages, usually to the detriment of the drinker's health, personal relationships, and social standing...
.