Angelica Charlotte Pickles is a character voiced by Cheryl Chase

Cheryl Chase

Cheryl Chase is an American voice actress best known as the voice of Angelica Pickles on Rugrats, All Grown Up! and Angelica and Susie's Pre-School Daze...

 in the Nickelodeon shows Rugrats

Rugrats

Rugrats is an American animated television series created by Arlene Klasky, Gábor Csupó, and Paul Germain for Nickelodeon. The series premiered on August 11, 1991, and aired its last episode on June 8, 2004....

and All Grown Up!

All Grown Up!

All Grown Up! is an American animated television series created by Arlene Klasky and Gábor Csupó. After the success of All Growed Up, the Rugrats 10th anniversary special, Nickelodeon commissioned All Grown Up! as a spin-off series based on the episode.The series ran from April 12, 2003 to August...

and is among the series' original characters. She is a spoiled brat and the cousin of Tommy

Tommy Pickles

Thomas Malcolm "Tommy" Pickles is the main protagonist of the Nickelodeon animated television series' Rugrats and its spin-off All Grown Up!. He is clad in only a T-shirt and a diaper and is bald with big, blank eyes. He translates everything adult into baby gibberish...

 and Dil Pickles

Dil Pickles

Dylan Prescott "Dil" Pickles is a fictional character. He is the younger brother of Tommy Pickles, younger son of Stu and Didi Pickles, and younger cousin of Angelica Pickles in the Nickelodeon film The Rugrats Movie, who later appeared in the show Rugrats, on which the film is based, and its...

, serves as the main antagonist

Antagonist

An antagonist is a character, group of characters, or institution, that represents the opposition against which the protagonist must contend...

 or the tritagonist

Tritagonist

In literature, the tritagonist is the third most important character of a narrative, after the protagonist and deuteragonist. In Ancient Greek drama, the tritagonist was the third member of the acting troupe....

 of the series. In 2002 TV Guide declared Angelica Pickles 7th in their list of "Top 50 Greatest Cartoon Characters of All Time". She is the archenemy

Archenemy

An archenemy, archfoe, archvillain or archnemesis is the principal enemy of a character in a work of fiction, often described as the hero's worst enemy .- Etymology :The word archenemy or arch-enemy originated...

 of the Rugrats.
In the Rugrats series, Angelica has dishwater blonde hair tied up in pigtails with purple bows.