Adenylosuccinate lyase
Encyclopedia
Adenylosuccinate lyase is an enzyme that converts adenylosuccinate
to AMP
and fumarate as part of the purine nucleotide cycle
.
Adenylosuccinate
Adenylosuccinate is an intermediate in the intercoversion of purine nucleotides inosine monophosphate and adenosine monophosphate . The enzyme adenylosuccinate synthase carries out the reaction by the addition of aspartate to IMP and requires the input of energy from a phosphoanhydride bond in the...
to AMP
Adenosine monophosphate
Adenosine monophosphate , also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine...
and fumarate as part of the purine nucleotide cycle
Purine nucleotide cycle
The Purine Nucleotide Cycle is a metabolic pathway in which fumarate is generated from aspartate in order to increase the concentration of Krebs cycle intermediates. The pathway was first described by John Lowenstein, who demonstrated its role in increasing the rate of oxidative phosphorylation in...
.