Acyl carrier protein synthase
Encyclopedia
Acyl carrier protein synthases (ACPS) are members of the family of phosphopantethienyl transferases responsible for the conversion of the inactive apo-Acyl carrier protein
from fatty acid
or polyketide
biosynthesis into the active holo form through the post-translational addition of a 4'-phosphopantethiene chain derived from coenzyme A
.
Acyl carrier protein
The acyl carrier protein is an important component in both fatty acid and polyketide biosynthesis with the growing chain bound during synthesis as a thiol ester at the distal thiol of a 4'-phosphopantethiene moiety...
from fatty acid
Fatty acid
In chemistry, especially biochemistry, a fatty acid is a carboxylic acid with a long unbranched aliphatic tail , which is either saturated or unsaturated. Most naturally occurring fatty acids have a chain of an even number of carbon atoms, from 4 to 28. Fatty acids are usually derived from...
or polyketide
Polyketide
Polyketides are secondary metabolites from bacteria, fungi, plants, and animals. Polyketides are usually biosynthesized through the decarboxylative condensation of malonyl-CoA derived extender units in a similar process to fatty acid synthesis...
biosynthesis into the active holo form through the post-translational addition of a 4'-phosphopantethiene chain derived from coenzyme A
Coenzyme A
Coenzyme A is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All sequenced genomes encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it as a substrate...
.