Aafact
Encyclopedia
Aafact is a monoclonal purified factor VIII
concentrate. It consists of a protein fraction prepared from fresh-frozen human plasma. It is used in cases of acute haemorrhage, pre-operative and post-operative treatment and prophylaxis in haemophilia A
patients (congenital factor VIII deficiency) and in patients with an acquired reduction in factor VIII activity. It is available as a powder for infusion for intravenous administration.
This transfer of a plasma
byproduct into the blood stream of a hemophiliac often led to the transmission of diseases such as HIV
and hepatitis
before purification methods were improved. In the early 1990s, pharmaceutical companies began to produce recombinant
synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy.
Factor VIII
Factor VIII is an essential blood clotting factor also known as anti-hemophilic factor . In humans, Factor VIII is encoded by the F8 gene...
concentrate. It consists of a protein fraction prepared from fresh-frozen human plasma. It is used in cases of acute haemorrhage, pre-operative and post-operative treatment and prophylaxis in haemophilia A
Haemophilia A
Haemophilia A is a deficiency in clotting factor VIII.Haemophilia A is inherited as an X-linked recessive trait, and thus occurs in males and in homozygous females. However, mild haemophilia A has been described in heterozygous females, presumably due to extremely unfavourable lyonization...
patients (congenital factor VIII deficiency) and in patients with an acquired reduction in factor VIII activity. It is available as a powder for infusion for intravenous administration.
This transfer of a plasma
Blood plasma
Blood plasma is the straw-colored liquid component of blood in which the blood cells in whole blood are normally suspended. It makes up about 55% of the total blood volume. It is the intravascular fluid part of extracellular fluid...
byproduct into the blood stream of a hemophiliac often led to the transmission of diseases such as HIV
HIV
Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...
and hepatitis
Hepatitis
Hepatitis is a medical condition defined by the inflammation of the liver and characterized by the presence of inflammatory cells in the tissue of the organ. The name is from the Greek hepar , the root being hepat- , meaning liver, and suffix -itis, meaning "inflammation"...
before purification methods were improved. In the early 1990s, pharmaceutical companies began to produce recombinant
Recombinant DNA
Recombinant DNA molecules are DNA sequences that result from the use of laboratory methods to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in biological organisms...
synthesized factor products, which now prevent nearly all forms of disease transmission during replacement therapy.