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(or GABA transaminase
) is an enzyme which catalyzes the conversion of 4-aminobutanoic acid (GABA) and 2-oxoglutarate into succinic semialdehyde
Succinic semialdehyde is a GABA analogue.-See also:* Succinic semialdehyde dehydrogenase deficiency* 4-aminobutyrate aminotransferase...
- Aminooxyacetic acid
Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase activity in vitro and in vivo, leading to less gamma-aminobutyric acid being broken down. Subsequently, the level of GABA is increased in tissues...
Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis, which acts as a potent and irreversible GABA transaminase inhibitor, and also a GABA reuptake inhibitor....
Phenelzine is a non-selective and irreversible monoamine oxidase inhibitor of the hydrazine class which is used as an antidepressant and anxiolytic...
Phenylethylidenehydrazine is an inhibitor of the enzyme GABA transaminase . It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations. PEH likely plays a significant role in phenelzine's high efficacy in treating anxiety disorders....
- Valproic acid
Valproic acid is a chemical compound that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, major depression. It is also used to treat migraine headaches and schizophrenia...
Vigabatrin is an antiepileptic drug that inhibits the catabolism of gamma-aminobutyric acid by irreversibly inhibiting GABA transaminase. It is an analog of GABA, but it is not a receptor agonist...