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4-aminobutyrate aminotransferase (or
GABA transaminase) is an enzyme which catalyzes the conversion of 4-aminobutanoic acid (GABA) and 2-oxoglutarate into
succinic semialdehydeSuccinic semialdehyde is a GABA analogue.-See also:* Succinic semialdehyde dehydrogenase deficiency* 4-aminobutyrate aminotransferase...
and glutamate.
Inhibitors
- Aminooxyacetic acid
Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase activity in vitro and in vivo, leading to less gamma-aminobutyric acid being broken down. Subsequently, the level of GABA is increased in tissues...
- Gabaculine
Gabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis, which acts as a potent and irreversible GABA transaminase inhibitor, and also a GABA reuptake inhibitor....
- Phenelzine
Phenelzine is a non-selective and irreversible monoamine oxidase inhibitor of the hydrazine class which is used as an antidepressant and anxiolytic...
- Phenylethylidenehydrazine
Phenylethylidenehydrazine is an inhibitor of the enzyme GABA transaminase . It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations. PEH likely plays a significant role in phenelzine's high efficacy in treating anxiety disorders....
(PEH)
- Valproic acid
Valproic acid is a chemical compound that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, major depression. It is also used to treat migraine headaches and schizophrenia...
- Vigabatrin
Vigabatrin is an antiepileptic drug that inhibits the catabolism of gamma-aminobutyric acid by irreversibly inhibiting GABA transaminase. It is an analog of GABA, but it is not a receptor agonist...