susue
hello,
I'm a graduating student in pharmaceutical chemistry and I'm doing a thesis on organic synthesis, I've been working on mannich's reaction for weeks with no results...I start from N-boc-4-piperidone, paraformaldehyde, N-benzylmethylamine, and i use solvents such as EtOH, CH3COOH(10:1)...I put it on reflux for 3-4 hours( 60°C), and stirring over night...after removing solvents I regain the residue with water and it risults in a white solid precipitate. After that I filtered it and dissolved a ppt in CHCl3 and washed i water to remove the residues of N-benzylmethylamine and others..the H-NMR Spectra is onfusing becase there are some signals between 3-5 ppm which I don't understand...is there anybody that could help me please, where am I wrong, or if somebody has another method it colud help. I tied also on Beilstein's bank data but in all reviews the reactions are based on cyclization ....Thank you.
Regards,
come on!!! need some help!!!pleaseeee
Sue
I'm a graduating student in pharmaceutical chemistry and I'm doing a thesis on organic synthesis, I've been working on mannich's reaction for weeks with no results...I start from N-boc-4-piperidone, paraformaldehyde, N-benzylmethylamine, and i use solvents such as EtOH, CH3COOH(10:1)...I put it on reflux for 3-4 hours( 60°C), and stirring over night...after removing solvents I regain the residue with water and it risults in a white solid precipitate. After that I filtered it and dissolved a ppt in CHCl3 and washed i water to remove the residues of N-benzylmethylamine and others..the H-NMR Spectra is onfusing becase there are some signals between 3-5 ppm which I don't understand...is there anybody that could help me please, where am I wrong, or if somebody has another method it colud help. I tied also on Beilstein's bank data but in all reviews the reactions are based on cyclization ....Thank you.
Regards,
come on!!! need some help!!!pleaseeee
Sue