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Zwitterion
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A zwitterion (first part pronounced "tsvitter", from German "Zwitter" — "hybrid," "hermaphrodite") is a chemical compound that carries a total net charge of 0, thus electrically neutral but carries formal positive and negative charges on different atoms. Some chemists restrict this term to refer to compounds with non-adjacent positive and negative charges. This would exclude compounds such as N-oxides. Zwitterions are polar and are usually very water-soluble, but poorly soluble in most organic solvents.
Ampholytes are molecules that contain both acidic and basic groups (and are therefore amphoteric) and will exist mostly as zwitterions in a certain range of pH.

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A zwitterion (first part pronounced "tsvitter", from German "Zwitter" — "hybrid," "hermaphrodite") is a chemical compound that carries a total net charge of 0, thus electrically neutral but carries formal positive and negative charges on different atoms. Some chemists restrict this term to refer to compounds with non-adjacent positive and negative charges. This would exclude compounds such as N-oxides. Zwitterions are polar and are usually very water-soluble, but poorly soluble in most organic solvents.
Ampholytes are molecules that contain both acidic and basic groups (and are therefore amphoteric) and will exist mostly as zwitterions in a certain range of pH. The pH at which the average charge is zero is known as the molecule's isoelectric point.
Applications Ampholytes are used to establish a stable pH gradient for use in isoelectric focusing.
Typical examples of zwitterions are:
Less common examples of zwitterions are:
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