Home      Discussion      Topics      Dictionary      Almanac
Signup       Login
Yopo

Yopo

Overview
"Ebene" redirects here. For the city in Mauritius, see Ebene City
Ebene City
Ebene City is a city on the island nation of Mauritius, 15 km south of the capital, Port Louis.Construction began in November, 2001, with the city being promoted as a new information technology hub for Mauritius and as a link between African and Asian markets -- as a result is referred to as Ebene...

.

Discussion
Ask a question about 'Yopo'
Start a new discussion about 'Yopo'
Answer questions from other users
Full Discussion Forum
 
Unanswered Questions
Encyclopedia
"Ebene" redirects here. For the city in Mauritius, see Ebene City
Ebene City
Ebene City is a city on the island nation of Mauritius, 15 km south of the capital, Port Louis.Construction began in November, 2001, with the city being promoted as a new information technology hub for Mauritius and as a link between African and Asian markets -- as a result is referred to as Ebene...

.

Anadenanthera peregrina, also known as Yopo, Jopo, Cohoba, Mopo, Nopo, Parica or Calcium Tree, is a perennial tree of the Anadenanthera
Anadenanthera
Anadenanthera is a genus of South American trees in the Legume family, Fabaceae. The genus contains two to four species, including A. colubrina and A. peregrina...

genus native to the Caribbean
Caribbean
The Caribbean is a crescent-shaped group of islands more than 2,000 miles long separating the Gulf of Mexico and the Caribbean Sea, to the west and south, from the Atlantic Ocean, to the east and north...

 and South America
South America
South America is a continent situated in the Western Hemisphere, mostly in the Southern Hemisphere, with a relatively small portion in the Northern Hemisphere. The continent is also considered a subcontinent of the Americas. It is bordered on the west by the Pacific Ocean and on the north and east...

. It grows up to 20 m tall, having a thorny bark. Its flowers are pale yellow to white and spherical. It is not listed as being a threatened species
Threatened species
Threatened species are any speciesg animals, plants, fungi, etc.) which are vulnerable to endangerment in the near future.The World Conservation Union is the foremost authority on threatened species, and treats threatened species not as a single category, but as a group of three categories,...

. It is an entheogen
Entheogen
An entheogen , in the strict sense, is a psychoactive substance used in a religious, shamanic, or spiritual context. Historically, entheogens were mostly derived from plant sources and have been used in a variety of traditional religious contexts...

 used in healing ceremonies and ritual
Ritual
A ritual is a set of actions, performed mainly for their symbolic value. It may be prescribed by a religion or by the traditions of a community. The term usually excludes actions which are arbitrarily chosen by the performers....

s. It is also a well known source of dietary calcium
Calcium
Calcium is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft gray alkaline earth metal, and is the fifth-most-abundant element by mass in the Earth's crust...

.

Related species


The usage complex of yopo is almost identical to that of a related tree, Anadenanthera colubrina, commonly known as Cebíl or Vilca. The beans of A. colubrina have a similar chemical makeup as Anadenanthera peregrina, with their primary constituent being 5-OH-DMT (bufotenin
Bufotenin
Bufotenin , or 5-hydroxy-dimethyltryptamine , is a tryptamine related to the neurotransmitter serotonin...

).

Botanical varieties

  • Anadenanthera peregrina var. falcata
    Anadenanthera peregrina var. falcata
    Anadenanthera peregrina var. falcata is a timber tree native to Paraguay and Cerrado vegetation in Brazil, specially in Mato Grosso, Mato Grosso do Sul, Minas Gerais, and São Paulo. This plant is also used as an ornamental and medicinal plant....

  • Anadenanthera peregrina var. peregrina
    Anadenanthera peregrina var. peregrina
    Anadenanthera peregrina var. peregrina is a tree in the Fabaceae family. It is native to Guyana, Venezuela, Brazil, Colombia and it is also found in the Caribbean.-Entheogen:In South America, Anadenanthera peregrina var...


Wood


The wood from A. peregrina is very hard and it is good for making furniture
Furniture
Furniture is the mass noun for the movable objects intended to support various human activities such as seating and sleeping in beds, to hold objects at a convenient height for work using horizontal surfaces above the ground, or to store things...

. It has a Janka
Janka Wood Hardness Rating
The Janka hardness test measures the resistance of a type of wood to withstand denting and wear. It measures the force required to embed an steel ball into wood to half the ball's diameter. This method leaves an indentation...

 rating of 3700 lb. and a density of around 0.86 g/cm³.

Toxicity


The beans (sometimes called seeds) and falling leaves are hallucinogenic and are toxic to cattle
Cattle
Cattle are the most common type of large domesticated ungulates. They are a prominent modern member of the subfamily Bovinae, are the most widespread species of the genus Bos, and are most commonly classified collectively as Bos primigenius...

.

Chemical compounds


Chemical compound
Chemical compound
A chemical compound is a pure chemical substance consisting of two or more different chemical elements that can be separated into simpler substances by chemical reactions. Chemical compounds have a unique and defined chemical structure; they consist of a fixed ratio of atoms that are held together...

s contained in A. peregrina include:
  • 1,2,3,4-Tetrahydro-6-methoxy-2,9-dimethyl-beta-carboline
    Beta-carboline
    β-Carboline is an organic amine that is the prototype of a class of compounds known as β-carbolines.-Pharmacology:...

    , Plant
  • 1,2,3,4-Tetrahydro-6-methoxy-2-methyl-beta-carboline, Plant
  • 5-Methoxy-N,N-dimethyltryptamine
    5-MeO-DMT
    5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

    , Bark
  • 5-Methoxy-N-methyltryptamine, Bark
  • Bufotenin
    Bufotenin
    Bufotenin , or 5-hydroxy-dimethyltryptamine , is a tryptamine related to the neurotransmitter serotonin...

    , Plant, beans
  • Bufotenin
    Bufotenin
    Bufotenin , or 5-hydroxy-dimethyltryptamine , is a tryptamine related to the neurotransmitter serotonin...

     N-oxide, Fruit, beans



  • Catechol, Plant
  • Homoorientine, Leaf
  • Leucoanthocyanin, Plant
  • Leucopelargonidol, Plant
  • N,N-Dimethyltryptamine
    Dimethyltryptamine
    N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

    , Fruit, beans, pods, bark
  • N,N-Dimethyltryptamine-oxide, Fruit
  • N-Methyltryptamine, Bark
  • Orientin
    Orientin
    Orientin is a flavone, a chemical flavonoid-like compound found in the passion flower, the Açaí palm, in Adonis vernalis and Anadenanthera peregrina. Orientin is also reported in millets and in the Phyllostachys nigra bamboo leaves....

    , Leaf
  • Saponarentin, Leaf
  • Viterine, Leaf


The bark and leaves contain tannin
Tannin
A tannin is an astringent, bitter plant polyphenolic compound that binds to and precipitates proteins and various other organic compounds including amino acids and alkaloids.The term tannin refers to the use of...

 and the beans contain saponin
Saponin
Saponins are a class of chemical compounds, one of many secondary metabolites found in natural sources, with saponins found in particular abundance in various plant species...

.

Traditional usage


Archaeological evidence shows Anadenanthera beans have been used as hallucinogens for thousands of years. The oldest clear evidence of use comes from smoking pipes made of puma bone (Felis Concolor) found with Anadenanthera beans at Inca Cueva, a site in the northwest of Humahuaca
Humahuaca
Humahuaca is a city in the province of Jujuy, Argentina. It has 11,369 inhabitants as per the , and is the principal town of the Department of Humahuaca...

 in the Puna
Puna
Puna may refer to:* Puna grassland, a type of grassland in the central part of the high Andes* Puna , the king of Hiti-marama or of Vavau in the Tuamotu legend of Rata* Puna , a type of wind in the Andes...

 border of the Province of Jujuy, Argentina
Argentina
Argentina , officially the Argentine Republic , is the second largest country in South America by land area, after Brazil. It is constituted as a federation of 23 provinces and an autonomous city, Buenos Aires...

. The pipes were found to contain the hallucinogen DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

, one of the compounds found in Anadenanthera beans. Radiocarbon testing of the material gave a date of 2130 B.C., suggesting Anadenanthera use as a hallucinogen is over 4000 years old. Snuff trays and tubes similar to those commonly used for yopo were found in the central Peruvian coast dating back to 1200 B.C., suggesting that insufflation
Insufflation (medicine)
Insufflation is the practice of inhaling a substance. Insufflation has limited medical use, but is a common route of administration with many respiratory drugs used to treat conditions in the lungs and paranasal sinus .The technique is common for many recreational drugs and is also used for some...

 of Anadenanthera beans is a more recent method of use. Archaeological evidence of insufflation use within the period 500-1000 A.D. in northern Chile has been reported.

Some indigenous peoples of the Orinoco
Orinoco
The Orinoco is one of the longest rivers in South America at . Its drainage basin, sometimes called the Orinoquia, covers , with 76.3% of it in Venezuela and the remainder in Colombia...

 basin in Colombia
Colombia
Colombia, officially the Republic of Colombia , is a unitary constitutional republic comprising thirty-two departments. The country is located in northwestern South America, bordered to the east by Venezuela and Brazil; to the south by Ecuador and Peru; to the north by the Caribbean Sea; to the...

, Venezuela
Venezuela
Venezuela , officially called the Bolivarian Republic of Venezuela , is a tropical country on the northern coast of South America. It borders Colombia to the west, Guyana to the east, and Brazil to the south...

 and possibly in the southern part of the Brazil
Brazil
Brazil , officially the Federative Republic of Brazil , is the largest country in South America. It is the world's fifth largest country, both by geographical area and by population with over 192 million people...

ian Amazon
Amazon Basin
The Amazon Basin is the part of South America drained by the Amazon River and its tributaries that drains an area of about , or roughly 40 percent of South America. The basin is located in the countries of Bolivia, Brazil, Colombia, Ecuador, Guyana, Peru, and Venezuela...

 make use of yopo snuff for spiritual healing. Yopo snuff was also widely used in ceremonial contexts in the Caribbean
Caribbean
The Caribbean is a crescent-shaped group of islands more than 2,000 miles long separating the Gulf of Mexico and the Caribbean Sea, to the west and south, from the Atlantic Ocean, to the east and north...

 area, including Cuba
Cuba
The Republic of Cuba is an island nation in the Caribbean. The nation of Cuba consists of the main island of Cuba, the Isla de la Juventud, and several archipelagos. Havana is the largest city in Cuba and the country's capital. Santiago de Cuba is the second largest city...

 and La Española, up to the Spanish Conquest.

Yopo snuff is usually blown into the user's nostrils by another person through bamboo
Bamboo
Bamboo is a group of perennial evergreens in the true grass family Poaceae, subfamily Bambusoideae, tribe Bambuseae. Giant bamboos are the largest members of the grass family....

 tubes or sometimes snuffed by the user using bird bone tubes. Blowing is more effective as this method allows more powder to enter the nose and is said to be less irritating. In some areas the unprocessed ground beans are snuffed or smoked producing a much weaker effect with stronger physical symptoms. Some tribes use yopo along with Banisteriopsis caapi
Banisteriopsis caapi
Banisteriopsis caapi, also known as Ayahuasca, Caapi or Yage, is a South American jungle vine of the family Malpighiaceae. It is used to prepare Ayahuasca, a decoction that has a long history of entheogenic uses as a medicine and "plant teacher" among the indigenous peoples of the Amazon Rainforest...

to increase and prolong the visionary effects, creating an experience similar to that of ayahuasca
Ayahuasca
Ayahuasca is any of various psychoactive infusions or decoctions prepared from the Banisteriopsis spp. vine, usually mixed with the leaves of dimethyltryptamine-containing species of shrubs from the Psychotria genus...

.

Snuff preparation



To make the psychedelic
Psychedelic
The term psychedelic is derived from the Greek words ψυχή and δηλοῦν , translating to "soul-manifesting". A psychedelic experience is characterized by the striking perception of aspects of one's mind previously unknown, or by the creative exuberance of the mind liberated from its ostensibly...

 snuff called yopo, the black beans from the bean pods of these trees are first toasted until the beans pop like popcorn
Popcorn
Popcorn, or popping corn, is corn which expands from the kernel and puffs up when heated. Corn is able to pop because, like sorghum, quinoa and millet, its kernels have a hard moisture-sealed hull and a dense starchy interior. This allows pressure to build inside the kernel until an explosive...

 breaking the bean's husk
Husk
Husk in botany is the outer shell or coating of a seed. It often refers to the leafy outer covering of an ear of maize as it grows on the plant. Literally, a husk or hull includes the protective outer covering of a seed, fruit or vegetable...

. The roasting process facilitates removal of the husk
Husk
Husk in botany is the outer shell or coating of a seed. It often refers to the leafy outer covering of an ear of maize as it grows on the plant. Literally, a husk or hull includes the protective outer covering of a seed, fruit or vegetable...

 and makes the beans easier to grind into a powder. The bean's husk
Husk
Husk in botany is the outer shell or coating of a seed. It often refers to the leafy outer covering of an ear of maize as it grows on the plant. Literally, a husk or hull includes the protective outer covering of a seed, fruit or vegetable...

 is usually removed because it is difficult to powderise and adds unnecessary volume. The bean is then ground with a mortar and pestle
Mortar and pestle
A mortar and pestle is a tool used to crush, grind, and mix solid substances . The pestle is a heavy bat-shaped object, the end of which is used for crushing and grinding. The mortar is a bowl, typically made of hard wood, ceramic or stone...

 into a powder and mixed with a natural form of calcium hydroxide
Calcium hydroxide
Calcium hydroxide, traditionally called slaked lime, is an inorganic compound with the chemical formula Ca2. It is a colourless crystal or white powder and is obtained when calcium oxide is mixed, or "slaked" with water. It has many names including hydrated lime, builders lime, slack lime, cal, or...

 (lime
Limestone
Limestone is a sedimentary rock composed largely of the minerals calcite and aragonite, which are different crystal forms of calcium carbonate . Many limestones are composed from skeletal fragments of marine organisms such as coral or foraminifera....

) or calcium oxide
Calcium oxide
Calcium oxide , commonly known as quicklime or burnt lime, is a widely used chemical compound. It is a white, caustic, alkaline crystalline solid at room temperature....

 (from certain types of ashes, calcined
Calcination
Calcination is a thermal treatment process applied to ores and other solid materials to bring about a thermal decomposition, phase transition, or removal of a volatile fraction. The calcination process normally takes place at temperatures below the melting point of the product materials...

 shells, etc.). This mix is then moistened to a consistency similar to bread
Bread
Bread is a staple food prepared by cooking a dough of flour and water and often additional ingredients. Doughs are usually baked, but in some cuisines breads are steamed , fried , or baked on an unoiled frying pan . It may be leavened or unleavened...

 dough
Dough
Dough is a paste made out of any cereals or leguminous crops by mixing flour with a small amount of water and/or other liquid. This process is a precursor to making a wide variety of foodstuffs, particularly breads and bread-based items , flatbreads, noodles, pastry, and similar items)...

, using a small amount of water. If calcium oxide is used, the water will react with it to form calcium hydroxide. Once moistened, it is kneaded into a ball for several minutes. After kneading, it is then left to sit for several hours to several days, depending on the local customs. During this period most of the excess calcium hydroxide reacts with the carbon dioxide
Carbon dioxide
Carbon dioxide is a naturally occurring chemical compound composed of two oxygen atoms covalently bonded to a single carbon atom...

 in the air to form less caustic calcium carbonate
Calcium carbonate
Calcium carbonate is a chemical compound with the formula CaCO3. It is a common substance found in rocks in all parts of the world, and is the main component of shells of marine organisms, snails, coal balls, pearls, and eggshells. Calcium carbonate is the active ingredient in agricultural lime,...

 (carbonatation
Carbonatation
Carbonatation is a chemical reaction in which calcium hydroxide reacts with carbon dioxide and forms insoluble calcium carbonate:The process of forming a carbonate is sometimes referred to as "carbonation", although this term usually refers to the process of dissolving carbon dioxide in...

).

Active constituents


Bufotenin


The beans have been found to contain up to 7.4% bufotenin
Bufotenin
Bufotenin , or 5-hydroxy-dimethyltryptamine , is a tryptamine related to the neurotransmitter serotonin...

. At up to 7.4 % (74 mg per gram) bufotenin, an effective 40 mg dose of insufflated bufotenin requires little more than 0.5 grams of beans.

The intraperitoneal  of bufotenin is between 200–300 mg/kg (in rodents) with death occurring by respiratory arrest. The LD50 in rodents amounts to between 10,000 mg and 15,000 mg for a small 50 kg (110 lb) adult. Based on the intraperitoneal LD50 for rodents, at 74 mg per gram, it would require approximately 135 grams of beans to reach the estimated LD50of bufotenin for a 50 kg (110 lb) adult. Human intravenous tests using bufotenin
Bufotenin
Bufotenin , or 5-hydroxy-dimethyltryptamine , is a tryptamine related to the neurotransmitter serotonin...

 suggest the LD50 may be much lower in humans with subjects showing signs of peripheral toxicity (purple face, tachycardia
Tachycardia
Tachycardia comes from the Greek words tachys and kardia . Tachycardia typically refers to a heart rate that exceeds the normal range for a resting heart rate...

, difficulty breathing, etc.) at doses as little as 8 mg in some subjects. Free base bufotenin when insufflated, taken sublingually, orally, or intrarectally, elicits strong hallucinogenic effects with far less side effects.

Dimethyltryptamine and 5-MeO-DMT


The effects of insufflated DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

 and 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

 are relatively short acting, lasting about 1 hour, while the effects of insufflated yopo typically last 2–3 hours. Of the three main compounds present, only insufflated bufotenine lasts 2–3 hours. Claims of Anadenanthera peregrina containing DMT and 5-MeO-DMT as their main active ingredients are based on rare cases where these compounds are found in larger quantities than bufotenine. Typical acid base extraction techniques utilizing strong bases such as sodium hydroxide solution will exclude bufotenin from the extraction, in favor of DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

 and 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

. It is believed that such extractions have contributed to the misconception that bufotenin is a minor alkaloid in yopo. The majority of the extractions confirm that bufotenin
Bufotenin
Bufotenin , or 5-hydroxy-dimethyltryptamine , is a tryptamine related to the neurotransmitter serotonin...

 is primarily responsible for the effects of yopo with the other compounds usually appearing in quantities too small to produce noticeable effects in an average yopo dose of 5-10 grams.

The beans have been found to contain up to only 0.04% 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

 and 0.16% DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

. The leaves and bark also contain small amounts of DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

, 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

 and related compounds.

At up to 0.04% (0.4 mg per gram) 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

, an effective light 5 mg dose of insufflated 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

 (5-MeO-DMT dosage, Erowid.org) would require over 12 grams of beans. It would be extremely difficult to insufflate the 12 grams of beans (approximately 72 beans) needed to reach the active dose of 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

 present in the beans. The body would begin to develop tolerance to 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

 before being able to insufflate all 12 grams of beans. Individual sensitivity to 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

 varies. It's been documented that the threshold dose in some individuals is as much as 10 mg insufflated requiring over 24 grams of beans for an effective dose of 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

.

At up to 0.16% (1.6 mg per gram) DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

, an effective 40 mg dose of insufflated DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

 would require 25 grams or more. It’s likely to be impossible to insufflate the 25 grams of beans required to reach the active dose of DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

 present in the beans. An extract of 25 grams of beans could contain up to 1,850 mg of bufotenin
Bufotenin
Bufotenin , or 5-hydroxy-dimethyltryptamine , is a tryptamine related to the neurotransmitter serotonin...

, a potentially dangerous dose of bufotenin
Bufotenin
Bufotenin , or 5-hydroxy-dimethyltryptamine , is a tryptamine related to the neurotransmitter serotonin...

. With insufflated free-base bufotenin
Bufotenin
Bufotenin , or 5-hydroxy-dimethyltryptamine , is a tryptamine related to the neurotransmitter serotonin...

, the maximum published safe dose used has been 100 mg.

Unlike bufotenin, both DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

 and 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

 are relatively unstable and begin to degrade rather quickly. Schultes and colleges (1977) examined a 120 year old bean collection and found 0.6% bufotenin with no DMT
Dimethyltryptamine
N,N-Dimethyltryptamine is a naturally occurring psychedelic compound of the tryptamine family. DMT is found in several plants, and also in trace amounts in humans and other mammals, where it is originally derived from the essential amino acid tryptophan, and ultimately produced by the enzyme INMT...

 or 5-MeO-DMT
5-MeO-DMT
5-MeO-DMT is a powerful psychedelic tryptamine. It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin , it has been used as an entheogen by South American shamans for thousands of years.-Chemistry:5-MeO-DMT was first synthesized in...

 present at all. They also examined a batch of beans that contained all three compounds when fresh, but found only bufotenin in the beans after only two years of storage.

Oral usage


When taken orally by some tribes in South America, small amounts are often combined with alcoholic chichas (maize based beer). Moderate doses are unpleasant, producing nausea and vomiting. The beans were a main ingredient in bilca tauri, an oral purge medicine used to induce ritual vomiting once a month. Large amounts are not usually consumed orally; as many tribes believe oral use is dangerous.

Use with MAOIs


Some South American tribes have been documented to use various bean preparations along with Banisteriopsis caapi
Banisteriopsis caapi
Banisteriopsis caapi, also known as Ayahuasca, Caapi or Yage, is a South American jungle vine of the family Malpighiaceae. It is used to prepare Ayahuasca, a decoction that has a long history of entheogenic uses as a medicine and "plant teacher" among the indigenous peoples of the Amazon Rainforest...

, a herb containing MAOIs. Typically Banisteriopsis caapi is chewed in the mouth while the Anadenanthera beans are snuffed or smoked. Occasionally Banisteriopsis caapi is found mixed in with the snuff. Moderate amounts of Banisteriopsis caapi will effectively double the potency of the Anadenanthera beans. Larger amounts of Banisteriopsis caapi will not only double the potency of Anadenanthera beans but also alter the quality of the experience, producing a more relaxed dreamy effect, with possible increased nausea. There are no well documented reports of the beans being used as a major component in ingestion of ayahuasca
Ayahuasca
Ayahuasca is any of various psychoactive infusions or decoctions prepared from the Banisteriopsis spp. vine, usually mixed with the leaves of dimethyltryptamine-containing species of shrubs from the Psychotria genus...

, a therapeutic tea made with Banisteriopsis caapi.

See also

  • List of plants of Caatinga vegetation of Brazil
  • Anadenanthera colubrina
  • Psychedelic plants
    Psychedelic plants
    A list of plants that are used for psychedelic drugs. Some of them have been used for thousands of years for religious purposes. The plants are listed according to the substances they contain.-THC:Cannabis is a popular psychedelic plant...


General references

  • Jonathan Ott
    Jonathan Ott
    Jonathan Ott is an ethnobotanist, writer, translator, publisher, natural products chemist and botanical researcher in the area of entheogens and their cultural and historical uses, and helped coin the term "entheogen".-Writings:...

     - Shamanic Snuffs or Entheogenic Errhines (2001) ISBN 1-888755-02-4
  • Richard Evans Schultes
    Richard Evans Schultes
    Richard Evans Schultes may be considered the father of modern ethnobotany, for his studies of indigenous peoples' uses of plants, including especially entheogenic or hallucinogenic plants , for his lifelong collaborations with chemists, and...

    - Plants of the Gods (1992) ISBN 0-89281-979-0

External links