Four ships of the U.S. Navy have been named USS Nautilus. after the Greek derivative meaning sailor or ship which gave also gave name to a tropical mollusk having a many chambered, spiral shell; and the submersible in Jules Verne's novel 20,000 Leagues Under the Sea.

• USS Nautilus (1799)
  USS Nautilus (1799)
  Nautilus was a schooner launched in 1799. The United States Navy purchased her in May 1803, renaming her the USS Nautilus; she thus became the first ship to bear that name. She served in the First Barbary War. She was altered to a brigantine. The British captured Nautilus early in the War of 1812...
  
  , a 12-gun schooner (1799–1812)
• USS Nautilus (1838)
  USS Nautilus (1838)
  USS Nautilus was a 76-foot schooner launched in 1838 for hydrographic surveying of the coast of the United States. She was commissioned into the United States Navy in 1847 for service in the Mexican–American War.-Coast and Geodetic Survey :...
  
  , a 76-foot coast survey schooner (1838–1859)
• USS Nautilus (SS-168)
  USS Nautilus (SS-168)
  USS Nautilus , a and one of the "V-boats", was the third ship of the United States Navy to officially bear that popular ship's name. She was originally named and designated V-6 , but was redesignated and given hull classification symbol SC-2 on 11 February 1925...
  
  , a Narwhal-class submarine (1930–1945)
• USS Nautilus (SSN-571)
  USS Nautilus (SSN-571)
  USS Nautilus is the world's first operational nuclear-powered submarine. She was the first vessel to complete a submerged transit beneath the North Pole on August 3, 1958...
  
  , the first nuclear submarine (1954–1980) and designated a National Historic Landmark
  National Historic Landmark
  A National Historic Landmark is a building, site, structure, object, or district, that is officially recognized by the United States government for its historical significance...
  
   in 1982.

Three other Navy ships have a related name:

• USS H-2 (SS-29)
  USS H-2 (SS-29)
  USS H-2 was a H-class submarine. She was originally named Nautilus, the third ship and first submarine of the United States Navy to bear the name, which was derived from a Greek word meaning "sailor" or "ship." The nautilus is also a tropical mollusk having a many-chambered, spiral shell with a...
  
  , a H-class submarine (1913–1930) called Nautilus only during construction
• USS Nautilus II (SP-559), a 66-foot patrol/escort (1917–1919), the U.S.