U.S. Route 43
Encyclopedia
U.S. Route 43 is a north–south United States highway that runs for 410 miles (649 km) from central Tennessee
Tennessee
Tennessee is a U.S. state located in the Southeastern United States. It has a population of 6,346,105, making it the nation's 17th-largest state by population, and covers , making it the 36th-largest by total land area...

 to Mobile, Alabama
Mobile, Alabama
Mobile is the third most populous city in the Southern US state of Alabama and is the county seat of Mobile County. It is located on the Mobile River and the central Gulf Coast of the United States. The population within the city limits was 195,111 during the 2010 census. It is the largest...

. The highway's southern terminus is in Mobile, Alabama
Mobile, Alabama
Mobile is the third most populous city in the Southern US state of Alabama and is the county seat of Mobile County. It is located on the Mobile River and the central Gulf Coast of the United States. The population within the city limits was 195,111 during the 2010 census. It is the largest...

, at U.S. Route 45
U.S. Route 45
U.S. Route 45 is a north–south United States highway. US 45 is a border-to-border route, from Lake Superior to the Gulf of Mexico. A sign at the highway's northern terminus notes the total distance as ....

. Its northern terminus is Columbia, Tennessee
Columbia, Tennessee
Columbia is a city in Maury County, Tennessee, United States. The 2008 population was 34,402 according to U.S. Census Bureau estimates. It is the county seat of Maury County....

, at U.S. Route 31
U.S. Route 31
U.S. Route 31 is a long north–south highway connecting northern Michigan to southern Alabama, with its northern terminus at Interstate 75 near Mackinaw City, Michigan, and southern terminus at the combined U.S. Route 90 & U.S. Route 98 at Spanish Fort, Alabama...

.

Alabama

Between Mobile
Mobile, Alabama
Mobile is the third most populous city in the Southern US state of Alabama and is the county seat of Mobile County. It is located on the Mobile River and the central Gulf Coast of the United States. The population within the city limits was 195,111 during the 2010 census. It is the largest...

 and Fayette
Fayette, Alabama
Fayette is a city in Fayette County, Alabama, United States. The 2000 census lists the population as 4,922. The city is the county seat of Fayette County.-Geography:Fayette is located at .According to the U.S...

 and again from Killen
Killen, Alabama
Killen is a town in Lauderdale County, Alabama, United States. It is part of the Florence - Muscle Shoals Metropolitan Statistical Area known as "The Shoals". As of the 2000 census, the population of the town is 1,190.-Geography:...

 to the Tennessee state line, U.S. 43 is paired with unsigned State Route 13
Alabama State Route 13
State Route 13 is a state highway in the western part of the U.S. state of Alabama. Except for a portion roughly between Berry and Russellville, SR-13 is the unsigned designation for U.S. Highway 43...

. Between Fayette and Hamilton
Hamilton, Alabama
Hamilton is a city in Marion County, Alabama, United States. At the 2000 census the population was 6,786. The city is the county seat of Marion County.-Geography:Hamilton is located at , along the Buttahatchee River....

, U.S. 43 is co-routed with unsigned State Route 171. Between Hamilton and Florence, the unsigned partner for U.S. 43 is State Route 17
Alabama State Route 17
State Route 17, or SR-17, is a long state route that runs the virtual length of the state. Between Mobile and Deer Park in Washington County, SR-17 is the unsigned partner route assigned to U.S. Highway 45, and from Hamilton to Florence, it serves as the signed partner route assigned to U.S...

. From its beginning in Mobile, Alabama
Mobile, Alabama
Mobile is the third most populous city in the Southern US state of Alabama and is the county seat of Mobile County. It is located on the Mobile River and the central Gulf Coast of the United States. The population within the city limits was 195,111 during the 2010 census. It is the largest...

, U.S. 43 passes through the western part of Alabama
Alabama
Alabama is a state located in the southeastern region of the United States. It is bordered by Tennessee to the north, Georgia to the east, Florida and the Gulf of Mexico to the south, and Mississippi to the west. Alabama ranks 30th in total land area and ranks second in the size of its inland...

. It serves as the principal route connecting Mobile and Tuscaloosa
Tuscaloosa, Alabama
Tuscaloosa is a city in and the seat of Tuscaloosa County in west central Alabama . Located on the Black Warrior River, it is the fifth-largest city in Alabama, with a population of 90,468 in 2010...

, and from Tuscaloosa to Muscle Shoals
Muscle Shoals, Alabama
Muscle Shoals is a city in Colbert County, Alabama, United States. As of 2007, the United States Census Bureau estimated the population of the city to be 12,846. The city is included in The Shoals MSA. It is famous for its contributions to American popular music.-Geography:Muscle Shoals is located...

 and Florence
Florence, Alabama
Florence is the county seat of Lauderdale County, Alabama, United States, in the northwestern corner of the state.According to the 2005 Census Bureau estimates, the city's population was 36,721....

. Prior to the completion of Interstate 65
Interstate 65
Interstate 65 is a major Interstate Highway in the United States. The southern terminus is located at an intersection with Interstate 10 in Mobile, Alabama, and its northern terminus is at an interchange with Interstate 90 , U.S. Route 12, and U.S...

, motorists traveling from Mobile to Birmingham
Birmingham, Alabama
Birmingham is the largest city in Alabama. The city is the county seat of Jefferson County. According to the 2010 United States Census, Birmingham had a population of 212,237. The Birmingham-Hoover Metropolitan Area, in estimate by the U.S...

 followed U.S. 43 to Thomasville
Thomasville, Alabama
Thomasville is a city in Clarke County, Alabama, United States. At the 2010 census the population was 4,209. Founded as a late 19th century railroad town, it has transitioned over the course of more than a century into a 21st century commercial hub...

; from there, they followed State Route 5 until its junction with U.S. Route 11
U.S. Route 11
U.S. Route 11 is a north–south United States highway extending 1,645 miles across the eastern United States. The southern terminus of the route is at U.S. Route 90 in the Bayou Sauvage National Wildlife Refuge in eastern New Orleans, Louisiana. The northern terminus is at the United...

 near West Blocton
West Blocton, Alabama
West Blocton is a town in Bibb County, Alabama, United States. At the 2000 census the population was 1,372.- Geography :West Blocton is located at ....

.

Except for Mobile, Tuscaloosa, and Muscle Shoals
Muscle Shoals, Alabama
Muscle Shoals is a city in Colbert County, Alabama, United States. As of 2007, the United States Census Bureau estimated the population of the city to be 12,846. The city is included in The Shoals MSA. It is famous for its contributions to American popular music.-Geography:Muscle Shoals is located...

/Florence
Florence, Alabama
Florence is the county seat of Lauderdale County, Alabama, United States, in the northwestern corner of the state.According to the 2005 Census Bureau estimates, the city's population was 36,721....

, U.S. 43 passes through rural areas and small towns.

Prior to the completion of Corridor X
Interstate 22
Interstate 22 , when it is completed, will follow the U.S. Highway 78 corridor along a 213-mile-long route from Memphis, Tennessee, to Birmingham, Alabama, as an Interstate Highway. Interstate 22 will connect Interstate 240 and Interstate 40 in the northwest with Interstate 65 and Interstate...

 in western Alabama, U.S. 43 and U.S. 278
U.S. Route 278
U.S. Route 278 is a parallel route of U.S. Route 78. It currently runs for 1,074 miles from Hilton Head Island, South Carolina to Wickes, Arkansas at U.S. Highway 71/U.S. Highway 59. It might be notable that it is longer than its parent highway, US Hwy-78. US Hwy-278 passes through the states of...

 shared a concurrency
Concurrency (road)
A concurrency, overlap, or coincidence in a road network is an instance of one physical road bearing two or more different highway, motorway, or other route numbers...

 with U.S. 78
U.S. Route 78
U.S. Highway 78 is an east–west United States highway that runs for 715 miles from Memphis, Tennessee, to Charleston, South Carolina. Between Memphis and Birmingham, Alabama, it is being upgraded to become Interstate 22....

 between Guin
Guin, Alabama
Guin is a city in Marion County, Alabama, United States. At the 2000 census the population was 2,389. On July 13, 2010, the citizens of Guin voted to become the first city in Marion County, since Prohibition, to allow the sale of alcohol....

 and Hamilton
Hamilton, Alabama
Hamilton is a city in Marion County, Alabama, United States. At the 2000 census the population was 6,786. The city is the county seat of Marion County.-Geography:Hamilton is located at , along the Buttahatchee River....

.

Major intersections

  • Interstate 65
    Interstate 65
    Interstate 65 is a major Interstate Highway in the United States. The southern terminus is located at an intersection with Interstate 10 in Mobile, Alabama, and its northern terminus is at an interchange with Interstate 90 , U.S. Route 12, and U.S...

     in Mobile, Alabama
    Mobile, Alabama
    Mobile is the third most populous city in the Southern US state of Alabama and is the county seat of Mobile County. It is located on the Mobile River and the central Gulf Coast of the United States. The population within the city limits was 195,111 during the 2010 census. It is the largest...

  • U.S. Route 84
    U.S. Route 84
    U.S. Route 84 is an east–west United States highway. It started as a short Georgia-Alabama route in the original 1926 scheme, but now extends all the way to Colorado. The highway's eastern terminus is a short distance east of Midway, Georgia, at an intersection with I-95. The road continues...

     in Grove Hill, Alabama
    Grove Hill, Alabama
    Grove Hill is a town in Clarke County, Alabama, United States. At the 2000 census the population was 1,438. It is the county seat of Clarke County and home of the Clarke County Museum.-History:...

  • U.S. Route 80
    U.S. Route 80
    U.S. Route 80 is an east–west United States highway, much of which was once part of the early auto trail known as the Dixie Overland Highway. As the "0" in the route number indicates, it was originally a cross-country route, from the Atlantic to the Pacific...

     in Demopolis, Alabama
    Demopolis, Alabama
    Demopolis is the largest city in Marengo County, Alabama, United States. The population was 7,483 at the time of the 2010 United States Census....

  • U.S. Route 11
    U.S. Route 11
    U.S. Route 11 is a north–south United States highway extending 1,645 miles across the eastern United States. The southern terminus of the route is at U.S. Route 90 in the Bayou Sauvage National Wildlife Refuge in eastern New Orleans, Louisiana. The northern terminus is at the United...

     in Eutaw, Alabama
    Eutaw, Alabama
    Eutaw is a city in Greene County, Alabama, United States. At the 2000 census the population was 1,878. The city is the county seat of Greene County and was named in honor of the Battle of Eutaw Springs, the last engagement of the American Revolutionary War in the Carolinas...

  • I-20/I-59 in Greene County, Alabama
    Greene County, Alabama
    Greene County is the least populous county in the U.S. state of Alabama. Its name is in honor of Revolutionary War General Nathanael Greene of Rhode Island. As of 2010 the population was 9,045...

  • Interstate 359
    Interstate 359
    Interstate 359 is a part of the Interstate Highway System in the US state of Alabama. It is a spur route that runs for entirely within the city limits of Tuscaloosa. Its termini are just south of I-20/I-59 interchange on the south side of town and U.S. Highway 43 in downtown Tuscaloosa. The...

     at Tuscaloosa, Alabama
    Tuscaloosa, Alabama
    Tuscaloosa is a city in and the seat of Tuscaloosa County in west central Alabama . Located on the Black Warrior River, it is the fifth-largest city in Alabama, with a population of 90,468 in 2010...

  • U.S. Route 82
    U.S. Route 82
    U.S. Route 82 is an east–west United States highway in the southern United States. What started as a 1932 addition to the system across central Mississippi and southern Arkansas eventually became a 1,609 mile route extending from the White Sands of New Mexico to Georgia's Atlantic coast.The...

     in Northport, Alabama
    Northport, Alabama
    Northport is a city in Tuscaloosa County in the west central part of the U.S. state of Alabama. Located on the Black Warrior River across from downtown Tuscaloosa, it is currently the 24th largest city in Alabama with an estimated population of 23,442 in 2009...

  • U.S. Route 78
    U.S. Route 78
    U.S. Highway 78 is an east–west United States highway that runs for 715 miles from Memphis, Tennessee, to Charleston, South Carolina. Between Memphis and Birmingham, Alabama, it is being upgraded to become Interstate 22....

     (Future I-22) in Hamilton, Alabama
    Hamilton, Alabama
    Hamilton is a city in Marion County, Alabama, United States. At the 2000 census the population was 6,786. The city is the county seat of Marion County.-Geography:Hamilton is located at , along the Buttahatchee River....

  • U.S. Route 72
    U.S. Route 72
    U.S. Route 72 is an east–west United States highway that runs for 337 miles from southeast Tennessee through northern Alabama and northern Mississippi to southwest Tennessee. The highway's eastern terminus is Chattanooga, Tennessee. Its western terminus is Memphis, Tennessee...

     in Muscle Shoals, Alabama
    Muscle Shoals, Alabama
    Muscle Shoals is a city in Colbert County, Alabama, United States. As of 2007, the United States Census Bureau estimated the population of the city to be 12,846. The city is included in The Shoals MSA. It is famous for its contributions to American popular music.-Geography:Muscle Shoals is located...

  • U.S. Route 64
    U.S. Route 64
    U.S. Route 64 is an east–west United States highway that runs for 2,326 miles from eastern North Carolina to just southwest of the Four Corners in northeast Arizona. The western terminus is at U.S. Route 160 in Teec Nos Pos, Arizona. The highway's eastern terminus is at NC 12 and U.S. Route...

     in Lawrenceburg, Tennessee
    Lawrenceburg, Tennessee
    Lawrenceburg is a city in Lawrence County, Tennessee, United States. The population was 10,796 at the 2000 census. It is the county seat of Lawrence County...

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