Tuberculosis vaccines
Encyclopedia
Tuberculosis vaccines are vaccination
s intended for the prevention of tuberculosis
. There is currently only one tuberculosis
vaccine
available, bacille Calmette-Guérin (BCG).
Other tuberculosis vaccines currently in development are:
) and Aeras
Vaccination
Vaccination is the administration of antigenic material to stimulate the immune system of an individual to develop adaptive immunity to a disease. Vaccines can prevent or ameliorate the effects of infection by many pathogens...
s intended for the prevention of tuberculosis
Tuberculosis
Tuberculosis, MTB, or TB is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis usually attacks the lungs but can also affect other parts of the body...
. There is currently only one tuberculosis
Tuberculosis
Tuberculosis, MTB, or TB is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis usually attacks the lungs but can also affect other parts of the body...
vaccine
Vaccine
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe or its toxins...
available, bacille Calmette-Guérin (BCG).
Other tuberculosis vaccines currently in development are:
- MVA85AMVA85AMVA85A is a new-generation vaccine against tuberculosis developed by researchers at Oxford University. This vaccine produces higher levels of long-lasting cellular immunity when used together with the old TB vaccine called BCG. Phase I clinical trials have been completed and phase II clinical...
- rBCG30RBCG30rBCG30 is a prospective vaccine against tuberculosis created by a team headed by Marcus A. Horwitz at UCLA. It is a live vaccine, consisting of BCG genetically modified to produce abundant amounts of a 30kDa antigen that has been shown to produce a strong immune response in animals and humans...
- 72F fusion protein72F fusion protein72F fusion protein is a candidate tuberculosis vaccine created by Statens Serum Institut . The 72F fusion protein is composed of the Rv0125 and Rv1196 proteins derived from Mycobacterium tuberculosis. Phase I clinical trials were completed in 2005 and Phase II trials are awaited....
- ESAT6-Ag85b fusion protein
Today
New vaccines are being developed by among others TuBerculosis Vaccine Initiative (TBVITBVI
TuBerculosis Vaccine Initiative is a European-based foundation that facilitates the development of new tuberculosis vaccines. The goal is to protect future generations against tuberculosis....
) and Aeras