Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cell

Mast cell

A mast cell is a resident cell of several types of tissues and contains many granules rich in histamine and heparin...

s that has been used as a marker for mast cell activation. It is involved with allergenic response and is suspected to act as a mitogen

Mitogen

A mitogen is a chemical substance that encourages a cell to commence cell division, triggering mitosis. A mitogen is usually some form of a protein.Mitogenesis is the induction of mitosis, typically via a mitogen....

 for fibroblast

Fibroblast

A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework for animal tissues, and plays a critical role in wound healing...

 lines. Elevated levels of serum tryptase occur in both anaphylactic and anaphylactoid reactions, but a negative test does not exclude anaphylaxis

Anaphylaxis

Anaphylaxis is defined as "a serious allergic reaction that is rapid in onset and may cause death". It typically results in a number of symptoms including throat swelling, an itchy rash, and low blood pressure...

.

Genes

Human genes that encode proteins with tryptase activity include:

Gene	Enzyme
TPSAB1 TPSAB1 Tryptase alpha-1 and tryptase beta-1 are enzymes that in humans are encoded by the same TPSAB1 gene. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate.- Function :...	Tryptase alpha-1
TPSAB1 TPSAB1 Tryptase alpha-1 and tryptase beta-1 are enzymes that in humans are encoded by the same TPSAB1 gene. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate.- Function :...	Tryptase beta-1
TPSB2 TPSB2 Tryptase beta-2, also known as tryptase II, is an enzyme that in humans is encoded by the TPSB2 gene.- Function :Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to...	Tryptase beta-2
TPSD1 TPSD1 Tryptase delta is an enzyme that in humans is encoded by the TPSD1 gene.-Further reading:...	Tryptase delta
TPSG1 TPSG1 Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme that in humans is encoded by the TPSG1 gene.- Function :Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1...	Tryptase gamma
PRSS22 PRSS22 Brain-specific serine protease 4 , also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene....	Tryptase epsilon