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Trypanosomiasis vaccine
 
 
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A Trypanosomiasis vaccine is a vaccine
Vaccine

A vaccine is a biological preparation that establishes or improves immunity to a particular disease.Vaccines can be prophylaxis , or Medication ....
 against trypanosomiasis
Trypanosomiasis

Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasite protozoan trypanosomes of the genus Trypanosoma....
. No effective vaccine currently exists, but development of a vaccine is the subject of current research. The Bill & Melinda Gates Foundation
Bill & Melinda Gates Foundation

The Bill & Melinda Gates Foundation is the fourth-largest Transparency operated private foundation in the world, founded by Bill Gates and Melinda Gates....
 has been involved in funding research.

There are many obstacles to development of such a vaccine. One obstacle is variant surface glycoprotein which makes it difficult for the immune system to recognize the infectious organism.

Also, Trypanosoma brucei
Trypanosoma brucei

'Trypanosoma BRYAN LI' is a parasitic protist species that causes African trypanosomiasis in humans and nagana in animals in Africa. There are 3 sub-species of T....
 has a direct inhibitory effect upon B cell
B cell

B cells are lymphocytes that play a large role in the humoral immunity . The principal functions of B cells are to make antibody against antigens, perform the role of Antigen Presenting Cells and eventually develop into memory B cells after activation by antigen interaction....
s.

One strategy may involve a vaccine against the initial antigens.

It has been suggested that it may be more productive to generate an immune response against the cysteine protease
Cysteine protease

Proteases are enzymes that degrade protein. Cysteine proteases have a common catalytic mechanism that involves a nucleophile cysteine thiol in a catalytic triad....
 (for example, cruzipain
Cruzipain

Cruzipain is a cysteine protease expressed by Trypanosoma cruzi.It is classified under .References...
), rather than the organism itself.








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Encyclopedia


A Trypanosomiasis vaccine is a vaccine
Vaccine

A vaccine is a biological preparation that establishes or improves immunity to a particular disease.Vaccines can be prophylaxis , or Medication ....
 against trypanosomiasis
Trypanosomiasis

Trypanosomiasis or trypanosomosis is the name of several diseases in vertebrates caused by parasite protozoan trypanosomes of the genus Trypanosoma....
. No effective vaccine currently exists, but development of a vaccine is the subject of current research. The Bill & Melinda Gates Foundation
Bill & Melinda Gates Foundation

The Bill & Melinda Gates Foundation is the fourth-largest Transparency operated private foundation in the world, founded by Bill Gates and Melinda Gates....
 has been involved in funding research.

There are many obstacles to development of such a vaccine. One obstacle is variant surface glycoprotein which makes it difficult for the immune system to recognize the infectious organism.

Also, Trypanosoma brucei
Trypanosoma brucei

'Trypanosoma BRYAN LI' is a parasitic protist species that causes African trypanosomiasis in humans and nagana in animals in Africa. There are 3 sub-species of T....
 has a direct inhibitory effect upon B cell
B cell

B cells are lymphocytes that play a large role in the humoral immunity . The principal functions of B cells are to make antibody against antigens, perform the role of Antigen Presenting Cells and eventually develop into memory B cells after activation by antigen interaction....
s.

One strategy may involve a vaccine against the initial antigens.

It has been suggested that it may be more productive to generate an immune response against the cysteine protease
Cysteine protease

Proteases are enzymes that degrade protein. Cysteine proteases have a common catalytic mechanism that involves a nucleophile cysteine thiol in a catalytic triad....
 (for example, cruzipain
Cruzipain

Cruzipain is a cysteine protease expressed by Trypanosoma cruzi.It is classified under .References...
), rather than the organism itself.

See also

  • Eradication_of_infectious_diseases#Human_African_Trypanosomiasis
    Eradication of infectious diseases

    Eradication is the reduction of an infectious disease's prevalence in the global human population to zero. A number of world organizations together with local governments are working to fully eradicate various diseases....
  • Trypanocidal agent
    Trypanocidal agent

    A trypanocidal agent is an antiprotozoal agent that acts upon on trypanosome parasites.Examples include:* benzonidazole* blasticidin S* DAPI...