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Toxic multinodular goitre (also known as toxic nodular goitre, toxic nodular struma) is a form of hyperthyroidism
Hyperthyroidism

Hyperthyroidism is the term for overactive tissue within the thyroid gland,resulting in overproduction and thus an excess of circulating free thyroid hormones: thyroxine , triiodothyronine , or both....
 - where there is excess production of thyroid hormones. It is characterized by functionally autonomous nodules. It emerges insidiously from nontoxic multinodular goitre.

It is the second most common cause of hyperthyroidism
Hyperthyroidism

Hyperthyroidism is the term for overactive tissue within the thyroid gland,resulting in overproduction and thus an excess of circulating free thyroid hormones: thyroxine , triiodothyronine , or both....
 after Graves disease.








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Toxic multinodular goitre (also known as toxic nodular goitre, toxic nodular struma) is a form of hyperthyroidism
Hyperthyroidism

Hyperthyroidism is the term for overactive tissue within the thyroid gland,resulting in overproduction and thus an excess of circulating free thyroid hormones: thyroxine , triiodothyronine , or both....
 - where there is excess production of thyroid hormones. It is characterized by functionally autonomous nodules. It emerges insidiously from nontoxic multinodular goitre.

It is the second most common cause of hyperthyroidism
Hyperthyroidism

Hyperthyroidism is the term for overactive tissue within the thyroid gland,resulting in overproduction and thus an excess of circulating free thyroid hormones: thyroxine , triiodothyronine , or both....
 after Graves disease.

Symptoms

Symptoms of toxic multinodular goitre are similar to that of hyperthyroidism
Hyperthyroidism

Hyperthyroidism is the term for overactive tissue within the thyroid gland,resulting in overproduction and thus an excess of circulating free thyroid hormones: thyroxine , triiodothyronine , or both....
, including:
  • heat intolerance
  • muscle weakness/wasting
  • hyperkinesis
    Hyperkinesis

    Hyperkinesis is a state of overactive restlessness in children. It is also a medical condition resulting in uncontrolled muscle movement, akin to spasms....
  • tremor
    Tremor

    Tremor is an unintentional, somewhat rhythmic, muscle movement involving to-and-fro movements of one or more body parts. It is the most common of all involuntary movements and can affect the hands, arms, head, face, vocal cords, trunk, and legs....
  • irritability
  • weight loss
    Weight loss

    Weight loss, in the context of medicine or health or physical fitness, is a reduction of the total body weight, due to a mean loss of fluid, body fat or adipose tissue and/or lean mass, namely bone mineral deposits, muscle, tendon and other connective tissue....
  • osteoporosis
    Osteoporosis

    Osteoporosis is a disease of bone that leads to an increased risk of bone fracture. In osteoporosis the bone mineral density is reduced, bone microarchitecture is disrupted, and the amount and variety of collagen proteins in bone is altered....
  • increased appetite
  • goitre
    Goitre

    A goitre , or goiter , also called a bronchocele, is a swelling in the neck due to an enlarged thyroid....
     (swelling of the thyroid gland)
  • tachycardia
    Tachycardia

    The word tachycardia comes from the Greek words tachys and kardia .Tachycardia typically refers to a heartrate that exceeds the range of the normal resting heartrate, based upon age:...
     (high heart rate - above 180 bpm at rest)


Related eponym

Plummer's disease is named after an American physician
Physician

A physician, medical practitioner, doctor of medicine, or medical doctor practices medicine, and is concerned with maintaining or restoring human health through the study, diagnosis, and treatment of disease and injury....
 Henry Stanley Plummer
Henry Stanley Plummer

Henry Stanley Plummer was a prominent internist and endocrinologist who was instrumental in the founding and flourishing of the Mayo Clinic. Dr....
 but refers to a single toxic nodule (adenoma) which may present with the background of a suppressed multinodular goitre.

Footnotes



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