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Tea Tree Oil

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Tea tree oil



 
 
Tea tree oil or melaleuca oil is a clear to very pale golden color essential oil
Essential oil

An essential oil is a concentrated, hydrophobic liquid containing volatile aroma compounds from plants. They are also known as volatile or ethereal oils, or simply as the "oil of" the plant material from which they were extracted, such as oil of clove....
 with a fresh camphor
Camphor

Camphor is a waxy, white or transparent solid with a strong, aromatic odor. It is a terpenoid with the chemical formula carbon10hydrogen16oxygen....
aceous odor
Odor

An odor or odour is a volatilized chemical compound, generally at a very low concentration, that humans or other animals perceive by the sense of olfaction....
. It is taken from the leaves
Leaf

In botany, a leaf is an above-ground plant Organ specialized for photosynthesis. For this purpose, a leaf is typically flat and thin, to expose the cells containing chloroplast to light over a broad area, and to allow light to penetrate fully into the tissues....
 of the Melaleuca alternifolia
Melaleuca alternifolia

Melaleuca alternifolia, commonly known as Narrow-leaved Paperbark, Narrow-leaved Tea-tree, Narrow-leaved Ti-tree, or Snow-in-summer, is a species of tree or tall shrub in the plant genus Melaleuca....
 which is native to the northeast coast of New South Wales
New South Wales

New South Wales is Australia's oldest and most populous States and territories of Australia, located in the south-east of the country, north of Victoria and south of Queensland....
, Australia
Australia

Australia, officially the Commonwealth of Australia, is a country in the southern hemisphere comprising the Australia of the world's smallest continent, the major island of Tasmania, and numerous list of islands of Australia in the Indian Ocean and Pacific Oceans....
. The oil has beneficial medical
Medicine

Medicine is the art and science of healing. It encompasses a range of health care practices evolved to maintain and restore health by the prevention and treatment of illness....
 properties (including antiseptic
Antiseptic

Antiseptics are antimicrobials that are applied to living biological tissue/skin to reduce the possibility of infection, sepsis, or putrefaction....
 and antifungal action), and is also believed to have beneficial cosmetic
Cosmetics

Cosmetics are substances used to enhance or protect the appearance or odor of the human body. Cosmetics include skin-care Cream , lotions, Powder , perfumes, lipsticks, fingernail and toe nail polish, eye and facial makeup, permanent waves, colored contact lenses, hair colors, hair sprays and gels, deodorants, baby products, bath oils, bubb...
 properties. Tea tree oil is usually used diluted, as reactions are common with pure tea tree oil.

Tea tree oil should not be confused with tea oil
Tea oil

Tea seed oil is an edible, pale amber-green fixed oil with a sweet, herbal aroma. It is cold-pressed mainly from the seeds of Camellia oleifera but also from Camellia sinensis or Camellia japonica....
, the sweet seasoning and cooking oil from pressed seeds of the tea plant (drinking tea) Camellia sinensis
Camellia sinensis

Camellia sinensis, the tea plant, is the species of plant whose leaves and leaf buds are used to produce tea. It is of the genus Camellia , a genus of flowering plants in the family Theaceae....
 or the tea oil plant Camellia oleifera
Camellia oleifera

Camellia oleifera, which originated in China, is notable as an important source of edible oil obtained from its seeds . It is commonly known as the Oil-seed Camellia, Tea Oil Camellia, or Lu Shan Snow Camellia, though to a lesser extent other species of Camellia are used in oil production too....
.

indigenous
Indigenous Australians

Indigenous Australians are the first human inhabitants of the Australian continent and its nearby islands and their descendants. Indigenous Australians are distinguished as either Australian Aborigines or Torres Strait Islanders, who currently together make up about 2.6% of Australia's population....
 Bundjalung people of eastern Australia use “tea trees” as a traditional medicine
Medicine

Medicine is the art and science of healing. It encompasses a range of health care practices evolved to maintain and restore health by the prevention and treatment of illness....
 by inhaling the oils from the crushed leaves to treat coughs and colds.






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Encyclopedia


Tea tree oil or melaleuca oil is a clear to very pale golden color essential oil
Essential oil

An essential oil is a concentrated, hydrophobic liquid containing volatile aroma compounds from plants. They are also known as volatile or ethereal oils, or simply as the "oil of" the plant material from which they were extracted, such as oil of clove....
 with a fresh camphor
Camphor

Camphor is a waxy, white or transparent solid with a strong, aromatic odor. It is a terpenoid with the chemical formula carbon10hydrogen16oxygen....
aceous odor
Odor

An odor or odour is a volatilized chemical compound, generally at a very low concentration, that humans or other animals perceive by the sense of olfaction....
. It is taken from the leaves
Leaf

In botany, a leaf is an above-ground plant Organ specialized for photosynthesis. For this purpose, a leaf is typically flat and thin, to expose the cells containing chloroplast to light over a broad area, and to allow light to penetrate fully into the tissues....
 of the Melaleuca alternifolia
Melaleuca alternifolia

Melaleuca alternifolia, commonly known as Narrow-leaved Paperbark, Narrow-leaved Tea-tree, Narrow-leaved Ti-tree, or Snow-in-summer, is a species of tree or tall shrub in the plant genus Melaleuca....
 which is native to the northeast coast of New South Wales
New South Wales

New South Wales is Australia's oldest and most populous States and territories of Australia, located in the south-east of the country, north of Victoria and south of Queensland....
, Australia
Australia

Australia, officially the Commonwealth of Australia, is a country in the southern hemisphere comprising the Australia of the world's smallest continent, the major island of Tasmania, and numerous list of islands of Australia in the Indian Ocean and Pacific Oceans....
. The oil has beneficial medical
Medicine

Medicine is the art and science of healing. It encompasses a range of health care practices evolved to maintain and restore health by the prevention and treatment of illness....
 properties (including antiseptic
Antiseptic

Antiseptics are antimicrobials that are applied to living biological tissue/skin to reduce the possibility of infection, sepsis, or putrefaction....
 and antifungal action), and is also believed to have beneficial cosmetic
Cosmetics

Cosmetics are substances used to enhance or protect the appearance or odor of the human body. Cosmetics include skin-care Cream , lotions, Powder , perfumes, lipsticks, fingernail and toe nail polish, eye and facial makeup, permanent waves, colored contact lenses, hair colors, hair sprays and gels, deodorants, baby products, bath oils, bubb...
 properties. Tea tree oil is usually used diluted, as reactions are common with pure tea tree oil.

Tea tree oil should not be confused with tea oil
Tea oil

Tea seed oil is an edible, pale amber-green fixed oil with a sweet, herbal aroma. It is cold-pressed mainly from the seeds of Camellia oleifera but also from Camellia sinensis or Camellia japonica....
, the sweet seasoning and cooking oil from pressed seeds of the tea plant (drinking tea) Camellia sinensis
Camellia sinensis

Camellia sinensis, the tea plant, is the species of plant whose leaves and leaf buds are used to produce tea. It is of the genus Camellia , a genus of flowering plants in the family Theaceae....
 or the tea oil plant Camellia oleifera
Camellia oleifera

Camellia oleifera, which originated in China, is notable as an important source of edible oil obtained from its seeds . It is commonly known as the Oil-seed Camellia, Tea Oil Camellia, or Lu Shan Snow Camellia, though to a lesser extent other species of Camellia are used in oil production too....
.

History and extraction


The indigenous
Indigenous Australians

Indigenous Australians are the first human inhabitants of the Australian continent and its nearby islands and their descendants. Indigenous Australians are distinguished as either Australian Aborigines or Torres Strait Islanders, who currently together make up about 2.6% of Australia's population....
 Bundjalung people of eastern Australia use “tea trees” as a traditional medicine
Medicine

Medicine is the art and science of healing. It encompasses a range of health care practices evolved to maintain and restore health by the prevention and treatment of illness....
 by inhaling the oils from the crushed leaves to treat coughs and colds. They also sprinkle leaves on wounds, after which a poultice
Poultice

A poultice, also called cataplasm, is a soft moist mass, often heated and medicated, that is spread on cloth over the skin to treat an aching, inflammation, or painful part of the body....
 is applied. In addition, tea tree leaves are soaked to make an infusion
Infusion

An infusion is the outcome of Wikt:steep plants with a desired flavour in water or edible oil.An infusion is very similar to a decoction but is used with herbs that are more volatile or dissolve readily in water, or release their active ingredients easily in oil....
 to treat sore throats or skin
Skin

The skin is the outer covering of the body, also known as the epidermis. It is the largest organ of the integumentary system made up of multiple layers of epithelial biological tissue, and guards the underlying muscles, bones, ligaments and organ s....
 ailments.

Use of the oil itself, as opposed to the unextracted plant material, did not become common practice until researcher Arthur Penfold published the first reports of its antimicrobial
Antimicrobial

An antimicrobial is a substance that kills or inhibits the growth of microbes such as bacteria, fungi, protozoals or viruses. Antimicrobial drugs either kill microbes or prevent the growth of microbes ....
 activity in a series of papers in the 1920s and 1930s. In evaluating the antimicrobial activity of M. alternifolia, tea tree oil was rated as 11 times more active than phenol
Phenol

Phenol, also known as carbolic acid, is a toxic, white crystalline solid with a sweet tarry odor, commonly referred to as a "hospital smell"....
.

The commercial tea tree oil industry
Industry

An industry is the manufacturing of a Good or Service within a category. Although industry is a broad term for any kind of economic production, in economics and urban planning industry is a synonym for the secondary sector, which is a type of economic activity involved in the manufacturing of raw materials into goods and products....
 was born after the medicinal properties of the oil were first reported by Penfold in the 1920s. It was produced from natural bush stands of M. alternifolia that produced oil with the appropriate chemotype
Chemotype

A chemotype is a chemically distinct entity in a plant or microorganism, with differences in the composition of the secondary metabolites. Minor Genetics and epigenetic changes with little or no effect on morphology may produce large changes in the chemical phenotype....
. The plant material was hand cut and often distilled on the spot in makeshift, mobile, wood-fired bush stills.

Production ebbed after World War II
World War II

World War II, or the Second World War , was a global military conflict which involved a Participants in World War II, including all of the great powers, organised into two opposing military alliances: the Allies of World War II and the Axis powers....
 as demand for the oil declined, presumably due to the development of effective antibiotics and the waning image of natural products. Interest in the oil was rekindled in the 1970s as part of the general renaissance of interest in natural products. Commercial plantations were established in the 1970s and 1980s, which lead to mechanization
Mechanization

Mechanization or mechanisation is providing human operators with machinery to assist them with the physical requirements of work. It can also refer to the use of machines to replace manual labor or animals....
 and large-scale production of a consistent essential oil product.

Among over 98 compounds
Chemical compound

A chemical compound is a Chemical substance consisting of two or more different chemical element Chemical bond together in a fixed mass ratio that can be split into simpler substances....
 contained in the oil, terpinen-4-ol
Terpinen-4-ol

Terpinen-4-ol is a terpene with a molecular weight of 154.249.It is considered the primary active ingredient of tea tree oil. It is also the compound of highest concentration in the essential oil of Nutmeg....
 is responsible for most of the antimicrobial actions.citation needed

Although tea tree oil is normally extracted from Melaleuca alternifolia
Melaleuca alternifolia

Melaleuca alternifolia, commonly known as Narrow-leaved Paperbark, Narrow-leaved Tea-tree, Narrow-leaved Ti-tree, or Snow-in-summer, is a species of tree or tall shrub in the plant genus Melaleuca....
 commercially, it can also be extracted from Melaleuca dissitiflora and Melaleuca linariifolia
Melaleuca linariifolia

Melaleuca linariifolia, popularly known as Snow-in-Summer, is a plant native to eastern Australia. Other names include Narrow-leaved Paperbark, Flax-leaved Paperbark and the Gadigal Budjur.....
.
Tea tree oil is defined by international standard ISO
International Organization for Standardization

The International Organization for Standardization , widely known as ISO , is an international standard-setting body composed of representatives from various national standards organizations....
 4730 (2004) ("Oil of Melaleuca, Terpinen-4-ol type"), which specifies levels of 15 components which are needed to define the oil as "tea tree oil."

Composition


Compound Tea tree oil ISO 4730 (2004) Concentration [%]
terpinen-4-ol
Terpinen-4-ol

Terpinen-4-ol is a terpene with a molecular weight of 154.249.It is considered the primary active ingredient of tea tree oil. It is also the compound of highest concentration in the essential oil of Nutmeg....
 
30-48
?-terpinene
Terpinene

The terpinenes are three isomeric hydrocarbons that are classified as terpenes. They each have the same molecular formula and carbon framework, but they differ in the position of carbon-carbon double bonds....
 
10–28
a-terpinene 5–13
1,8-Cineole 0–15
a-terpinolene 1.5–5
a-terpineol 1.5–8
a-pinene 1–6
p-cymene 0.5–8


Medicinal use


Tea tree oil has been recognized as a potent antiseptic
Antiseptic

Antiseptics are antimicrobials that are applied to living biological tissue/skin to reduce the possibility of infection, sepsis, or putrefaction....
 in Australia
Australia

Australia, officially the Commonwealth of Australia, is a country in the southern hemisphere comprising the Australia of the world's smallest continent, the major island of Tasmania, and numerous list of islands of Australia in the Indian Ocean and Pacific Oceans....
 anecdotally for much longer than there has been scientific evidence. However, recent studies support a role for tea tree oil in skin care and treatment of various ailments.

Tea tree oil is a known antifungal agent, effective in vitro
In vitro

In vitro refers to the technique of performing a given procedure in a controlled environment outside of a living organism. Some may argue that in vitro refers to a process that is created in a "test tube"; however, Robert Kail and John Cavanaugh on page 58 in the 4th edition of Human Development: A Life-Span View cite that in fact th...
 against multiple dermatophyte
Dermatophyte

A dermatophyte is a parasitic fungus that infects the skin. The term embraces the imperfect fungi of the genera Epidermophyton, Microsporum and Trichophyton....
s found on the skin. In vivo
In vivo

In vivo means that which takes place inside an organism. In science, in vivo refers to experimentation done in or on the living tissue of a whole, living organism as opposed to a partial or dead one or a in vitro....
, shampoo with 5% tea tree oil has been shown to be an effective treatment for dandruff
Dandruff

Dandruff is due to the excessive shedding of dead skin cells from the scalp. As it is normal for skin cell s to die and flake off, a small amount of flaking is normal and in fact quite common....
 due to its ability to treat Malassezia furfur
Malassezia furfur

Malassezia is a genus of related fungi, classified as yeasts, naturally found on the skin surfaces of many animals including humans. It can cause hypopigmentation on the chest or back if it becomes an opportunistic infection....
, the most common cause of the condition.

Effectiveness of topical tea tree oil preparations for Candidiasis
Candidiasis

Candidiasis, commonly called yeast infection or thrush, is a fungal infection of any of the Candida species, of which Candida albicans is the most common....
 is supported by their ability to kill Candida
Candida (genus)

Candida is a genus of yeasts. Many species of this genus are endosymbionts of animal hosts including humans. While usually living as Commensalisms, some Candida species have the potential to cause disease....
 in vitro.

In the treatment of moderate acne
Acne vulgaris

Acne vulgaris is a skin condition caused by changes in the pilosebaceous units . Severe acne is inflammation, but acne can also manifest in noninflammatory forms....
, topical application of 5% tea tree oil has shown an effect comparable to 5% benzoyl peroxide
Benzoyl peroxide

Benzoyl peroxide is a chemical in the organic peroxide family. It consists of two benzoyl groups joined by a peroxide group. Acceptable condensed structural formulae would include C6H5-COO-OOC-C6H5, PhCO-O-O-COPh, and 2O2....
, albeit with slower onset of action. In another study in 2007 5% strength gel was compared against a placebo, with statistically significant results.

There is some limited research that has shown that tea tree oil may have topical anti-viral activity, especially with the Herpes virus (cold sores, chicken pox and shingles blisters, etc.)

One study has shown a 5% tea tree oil solution to be more effective than commercial medications against the scabies
Scabies

Scabies is a contagious Parasitism skin infection characterized by superficial burrows, intense pruritus and secondary infection. It is etiology by the mite Sarcoptes scabiei....
 mite in an in vitro
In vitro

In vitro refers to the technique of performing a given procedure in a controlled environment outside of a living organism. Some may argue that in vitro refers to a process that is created in a "test tube"; however, Robert Kail and John Cavanaugh on page 58 in the 4th edition of Human Development: A Life-Span View cite that in fact th...
 situation.

Flea control


Tea tree oil has long been used as a method of all natural effective flea
Flea

Flea is the common name for insects of the order Siphonaptera which are wingless insects whose mouthparts are adapted for piercing skin and sucking blood....
 control by adding the oil directly to dogs, horses and sheep fur or their bathing water. Use on cats has been known to make them sick and in some cases kill them, this is due to cats licking their fur and consuming the oil.

According to National Animal Poison Control Center, the use of tea tree oil in dogs has been associated with hypothermia, muscle weakness, ataxia, tremors, altered behavior, paralysis. A case report has been published in which three cats had clinical signs and one cat died after being treated with the oil.

Safety

According to the American Cancer Society: "Tea tree oil is toxic when swallowed. It has been reported to cause drowsiness, confusion, hallucinations, coma, unsteadiness, weakness, vomiting, diarrhea, stomach upset, blood cell abnormalities, and severe rashes. It should be kept away from pets and children."

A small number of people experience allergic contact dermatitis as a reaction to dermal contact with tea tree oil. In an Italian study of 725 consecutive patients, patients were patch tested with undiluted, 1% and 0.1% Tea Tree Oil. For undiluted tea tree oil, nearly 6% of the patients observed positive reactions of skin irritation. Only 1 of 725 patients observed a positive reaction of skin irritation with the 1% dilution. None of the 725 patients observed adverse reactions with the 0.1% dilution. Allergic reactions may be due to the various oxidation products that are formed by exposure of the oil to light and/or air.

External application of undiluted tea tree oil and/or at inappropriate high doses has been associated with toxicity, including death, in cats and other animals.

A disputed case study reported in The New England Journal of Medicine concluded that "repeated topical exposure to lavender and tea tree oils probably caused prepubertal gynecomastia
Gynecomastia

Gynecomastia, or gynaecomastia, is the development of abnormally large mammary glands in males resulting in breast enlargement, which can sometimes cause secretion of milk....
" (abnormal breast development) in three young boys. The study involved just three individuals and found lavender to be the only common ingredient used by the boys in the study. While all three cases involved the use of products containing lavender oil
Lavender oil

Lavender oil is an essential oil obtained by distillation from the flower spikes of certain species of lavender. Two forms are distinguished, lavender flower oil, a colorless oil, insoluble in water, having a density of 0.885 g/mL; and lavender spike oil, a distillate from the herb Lavandula latifolia, having density 0.905&n...
 as an ingredient, only one boy also used products containing tea tree oil. In all cases, the prepubertal gynecomastia reversed after several months.

Use of the products containing lavender and tea tree oils were also discontinued during this time. In the same paper, results from cell culture assays indicated that both essential oils exhibit weak estrogenic and antiandrogenic properties in vitro
In vitro

In vitro refers to the technique of performing a given procedure in a controlled environment outside of a living organism. Some may argue that in vitro refers to a process that is created in a "test tube"; however, Robert Kail and John Cavanaugh on page 58 in the 4th edition of Human Development: A Life-Span View cite that in fact th...
, but no tests were conducted in vivo. Researchers also indicated that other components in these products may also have contributed to the gynecomastia, or that genetics might play a role. Researchers also noted that estrogenic or antiandrogenic activities have also been reported for some other commonly used essential oils as well as some foods such as almonds and peanuts, but cited no associated cases of prepubertal gynecomastia.

If used in concentrations below 4% or particularly below 1%, tea tree oil may fail to kill bacteria and create an evolutionary pressure which may result in them becoming less sensitive to tea tree oil and even some antibiotics in vitro.

Tea tree oil may cause hearing loss when used in the ears.

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