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TRAF2

TRAF2

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Encyclopedia
TNF receptor-associated factor 2 is a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the TRAF2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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Interactions


TRAF2 has been shown to interact
Protein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with BCL10
BCL10
B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene.-Interactions:BCL10 has been shown to interact with CARD10, CARD11, MALT1, TRAF2, IKBKG and CARD9.-Further reading:...

, CD30
CD30
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the...

, CFLAR
CFLAR
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called FLICE-like inhibitory protein .-Further reading:...

, IKK2
IKK2
IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB gene.- Function :...

, MAP3K7IP2
MAP3K7IP2
Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK...

, CD137
CD137
CD137 is a member of the tumor necrosis factor receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 , 4-1BB and induced by lymphocyte activation .-Expression:...

, Caveolin 1, CD27
CD27
CD27 is a tumor necrosis factor receptor.-Interactions:CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3.-External links:...

, TNFRSF13B
TNFRSF13B
Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system....

, TANK-binding kinase 1
TANK-binding kinase 1
Serine/threonine-protein kinase TBK1 is an enzyme that in humans is encoded by the TBK1 gene.-Interactions:TANK-binding kinase 1 has been shown to interact with NCK1, TRAF2 and TANK.-Further reading:...

, TRAF1
TRAF1
TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.-Interactions:TRAF1 has been shown to interact with CD30, CFLAR, Baculoviral IAP repeat-containing protein 3, BIRC2, Caspase 8, HIVEP3, TNFAIP3, TRAF2, RANK and TRAF interacting protein.-Further reading:...

, CD40
CD40 (protein)
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects....

, UBE2N
UBE2N
Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene.-Interactions:UBE2N has been shown to interact with Aurora A kinase, TRAF2, TRAF6, HLTF and UBE2V1.-Further reading:...

, MAP3K14
MAP3K14
Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase is an enzyme that in humans is encoded by the MAP3K14 gene.- Function :...

, MAP4K2
MAP4K2
Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene.-Interactions:MAP4K2 has been shown to interact with RAB8A and TRAF2.-Further reading:...

, CASP8AP2
CASP8AP2
CASP8-associated protein 2 is a protein that in humans is encoded by the CASP8AP2 gene.-Further reading:...

, HIVEP3
HIVEP3
Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.-Interactions:HIVEP3 has been shown to interact with TRAF1 and TRAF2....

, TNFAIP3
TNFAIP3
Tumor necrosis factor, alpha-induced protein 3 is a protein that in humans is encoded by the TNFAIP3 gene.-Interactions:TNFAIP3 has been shown to interact with TNIP1, TRAF1, TRAF2, IKBKG, TAX1BP1, YWHAB, YWHAZ, TRAF6 and YWHAH....

, TNFRSF1B
TNFRSF1B
Tumor necrosis factor receptor superfamily member 1B is a protein that in humans is encoded by the TNFRSF1B gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. The protein encoded by this gene is a member of the...

, TNFRSF1A
TNFRSF1A
Tumor necrosis factor receptor superfamily member 1A is a protein that in humans is encoded by the TNFRSF1A gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor...

, SPHK1
Sphingosine kinase 1
Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene.Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate SK1 is normally a cytosolic protein but is recruited to membranes rich in phosphatidate , a product of Phospholipase D Sphingosine-1-phosphate ...

, Low affinity nerve growth factor receptor
Low Affinity Nerve Growth Factor Receptor
The Low-Affinity Nerve Growth Factor Receptor is one of the two receptor types for the neurotrophins, a family of protein growth factors that stimulate neuronal cells to survive and differentiate...

, TNFRSF14
TNFRSF14
Tumor necrosis factor receptor superfamily member 14 is a protein that in humans is encoded by the TNFRSF14 gene. It is also known as "herpesvirus entry mediator" .-Interactions:...

, CHUK
CHUK
Inhibitor of nuclear factor kappa-B kinase subunit alpha also known as IKK1 or conserved helix-loop-helix ubiquitous kinase is a protein kinase that in humans is encoded by the CHUK gene. IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription...

, CD134
CD134
CD134, also known as OX40, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary costimulatory molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on...

, EDARADD
EDARADD
Ectodysplasin-A receptor-associated adapter protein is a protein that in humans is encoded by the EDARADD gene.-Further reading:...

, RIPK1
RIPK1
Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene.-Interactions:RIPK1 has been shown to interact with CA11, RIPK3, RNF11, Baculoviral IAP repeat-containing protein 3, CFLAR, BIRC2, Caspase 8, RNF216, TNFRSF1A, Sequestosome 1, TRAF2,...

, RANK
RANK
Receptor Activator of Nuclear Factor κ B , also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding...

, TNFSF14
TNFSF14
Tumor necrosis factor ligand superfamily member 14 is a protein that in humans is encoded by the TNFSF14 gene. TNFSF14 has also been designated as CD258, as well as LIGHT.-Interactions:...

, TANK
TANK (gene)
TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.-Interactions:TANK has been shown to interact with TANK-binding kinase 1, IKBKE, TRAF2, IKBKG and TRAF3.-Further reading:...

, Baculoviral IAP repeat-containing protein 3
Baculoviral IAP repeat-containing protein 3
Baculoviral IAP repeat-containing protein 3 is a protein that in humans is encoded by the BIRC3 gene.-Interactions:...

, BIRC2
BIRC2
Baculoviral IAP repeat-containing protein 2 is a protein that in humans is encoded by the BIRC2 gene.-Interactions:...

, MAP4K5
MAP4K5
Mitogen-activated protein kinase kinase kinase kinase 5 is an enzyme that in humans is encoded by the MAP4K5 gene.-Interactions:MAP4K5 has been shown to interact with CRKL and TRAF2.-Further reading:...

, ASK1
ASK1
Apoptosis signal-regulating kinase 1 also known as mitogen-activated protein kinase kinase kinase 5 is a member of MAP kinase kinase kinase family and as such a part of mitogen-activated protein kinase pathway...

, TRADD
TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.TRADD is an adaptor protein.- Function :...

, MAP3K1
MAP3K1
Mitogen-activated protein kinase kinase kinase 1 is an enzyme that in humans is encoded by the MAP3K1 gene.Mouse genetics has revealed that the kinase is important in: correct embryogenesis, keratinocyte migration, T cell cytokine production and B cell antibody production.-Interactions:MAP3K1 has...

 and TRAF interacting protein
TRAF interacting protein
TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.-Interactions:TRAF interacting protein has been shown to interact with FLII, TRAF1 and TRAF2.-Further reading:...

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Further reading